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1.发明申请
公开(公告)号：WO2004101769A3
公开(公告)日：2005-04-21
申请号：PCT/US2004006276
申请日：2004-03-01
Applicant: UNIV MARYLAND , TOLOSA LEAH , RAO GOVIND , GE XUDONG
Inventor： TOLOSA LEAH , RAO GOVIND , GE XUDONG
IPC: C12N20060101 , G01N33/558
CPC classification number: G01N33/542 , Y10T436/143333 , Y10T436/144444 , Y10T436/17
Abstract: A protein sensing molecule is capable of binding an analyte in a sample. The protein sensing molecule includes a first detectable quality that changes in a concentration dependent manner when the protein sensing molecule is bound to the analyte. The protein sensing molecule also includes a second detectable quality that does not undergo substantial change when the protein sensing molecule is bound to the analyte. The protein sensing molecule may be used in methods for characterizing samples and may also be used in sensors.
Abstract translation: 蛋白质感测分子能够结合样品中的分析物。 当蛋白质感测分子与分析物结合时，蛋白质感测分子包括以浓度依赖性方式变化的第一可检测质量。 蛋白质感测分子还包括当蛋白质感测分子与分析物结合时不经历实质性变化的第二可检测质量。 蛋白质感测分子可用于表征样品的方法中，也可用于传感器。
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公开(公告)号：EP1098658A4
公开(公告)日：2008-01-02
申请号：EP99935583
申请日：1999-07-15
Applicant: UNIV MARYLAND
Inventor： LAKOWICZ JOSEPH R , TOLOSA LEAH , EICHHORN LISA , RAO GOVIND
CPC classification number: G01N33/542 , C12Q1/485 , C12Q1/54 , G01N33/66 , G01N33/68 , Y10S435/968
Abstract: Disclosed are methods and sensors for detecting the presence or concentration of an analyte in a sample, preferably a sugar such as glucose, which preferably utilizes a labeled engineered protein, or fragment thereof, that is capable of binding the analyte to be detected.
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公开(公告)号：DE69941085D1
公开(公告)日：2009-08-20
申请号：DE69941085
申请日：1999-07-15
Applicant: UNIV MARYLAND
Inventor： LAKOWICZ JOSEPH R , TOLOSA LEAH , EICHHORN LISA , RAO GOVIND
Abstract: Disclosed are methods and sensors for detecting the presence or concentration of an analyte in a sample, preferably a sugar such as glucose, which preferably utilizes a labeled engineered protein, or fragment thereof, that is capable of binding the analyte to be detected.
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公开(公告)号：CA2524095A1
公开(公告)日：2004-11-25
申请号：CA2524095
申请日：2004-03-01
Applicant: UNIV MARYLAND
Inventor： GE XUDONG , TOLOSA LEAH , RAO GOVIND
IPC: G01N33/558 , C12N20060101
Abstract: A protein sensing molecule is capable of binding an analyte in a sample. The protein sensing molecule includes a first detectable quality that changes in a concentration dependent manner when the protein sensing molecule is bound to the analyte. The protein sensing molecule also includes a second detectable quality that does not undergo substantial change when the protein sensing molecule is bound to the analyte. The protein sensing molecule may be used i n methods for characterizing samples and may also be used in sensors.
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公开(公告)号：EP2443224A4
公开(公告)日：2014-10-22
申请号：EP10790320
申请日：2010-06-21
Applicant: UNIV MARYLAND
Inventor： RAO GOVIND , KOSTOV YORDAN , TOLOSA LEAH
IPC: C12M1/12
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Patent Agency Ranking
公开(公告)号：EP2389447A4
公开(公告)日：2012-06-20
申请号：EP10733960
申请日：2010-01-25
Applicant: UNIV MARYLAND
Inventor： RAO GOVIND , LAM HUNG , KOSTOV YORDAN , TOLOSA LEAH , GE XUDONG
CPC classification number: G01N33/5308 , G01N21/05 , G01N21/15 , G01N21/532 , G01N21/645 , G01N21/6486 , G01N21/82 , G01N21/8507 , G01N2021/635 , G01N2021/6432 , G01N2201/0218 , G01N2201/0627
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公开(公告)号：WO2012045047A2
公开(公告)日：2012-04-05
申请号：PCT/US2011054437
申请日：2011-09-30
Applicant: UNIV MARYLAND , RAO GOVIND , KOSTOV YORDAN , GE XUDONG , TOLOSA LEAH , WOO HYUNG , VISCARDI ROSE
Inventor： RAO GOVIND , KOSTOV YORDAN , GE XUDONG , TOLOSA LEAH , WOO HYUNG , VISCARDI ROSE
IPC: A61B5/1455
CPC classification number: A61B5/14552 , A61B5/6807 , A61B5/6829
Abstract: A non-invasive gas analyte sensing and monitoring system and method is provided that is particularly applicable to transcutaneous monitoring of arterial blood gases in a mammal. The system and method relies on diffusion of the analyte to be measured into a diffusion chamber and remote sensing of the analyte in the diffusion chamber using optical chemical sensors and associated optoelectronics.
Abstract translation: 提供一种非侵入性气体分析物感测和监测系统和方法，其特别适用于哺乳动物的动脉血气的经皮监测。 该系统和方法依赖于待测量分析物扩散到扩散室中，并使用光学化学传感器和相关联的光电子学来远程检测扩散室中的分析物。
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公开(公告)号：WO0003727A9
公开(公告)日：2000-07-20
申请号：PCT/US9915998
申请日：1999-07-15
Applicant: UNIV MARYLAND
Inventor： LAKOWICZ JOSEPH R , TOLOSA LEAH , EICHHORN LISA , RAO GOVIND
CPC classification number: G01N33/542 , C12Q1/485 , C12Q1/54 , G01N33/66 , G01N33/68 , Y10S435/968
Abstract: Disclosed are methods and sensors for detecting the presence or concentration of an analyte in a sample, preferably a sugar such as glucose, which preferably utilizes a labeled engineered protein, or fragment thereof, that is capable of binding the analyte to be detected.
Abstract translation: 公开了用于检测样品（优选糖例如葡萄糖）中分析物的存在或浓度的方法和传感器，其优选利用能够结合待检测分析物的标记工程蛋白或其片段。
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9.发明申请ANALYTE SENSING SYSTEM AND METHOD UTILIZING SEPARATE EQUILIBRIUM AND MEASUREMENT CHAMBERS 审中-公开利用分离平衡和测量室的分析物传感系统和方法
公开(公告)号：WO2012045046A3
公开(公告)日：2012-05-24
申请号：PCT/US2011054434
申请日：2011-09-30
Applicant: UNIV MARYLAND , RAO GOVIND , KOSTOV YORDAN , GE XUDONG , TOLOSA LEAH , LAM HUNG , HENDERSON ROBERT
Inventor： RAO GOVIND , KOSTOV YORDAN , GE XUDONG , TOLOSA LEAH , LAM HUNG , HENDERSON ROBERT
CPC classification number: G01N21/643 , G01N21/77 , G01N21/78 , G01N31/223 , G01N33/1886 , G01N2021/7733 , G01N2021/7786 , G01N2201/0612 , G01N2201/062
Abstract: An analyte sensing system is provided that utilizes separate and decoupled equilibrium and measurement chambers for improved sensitivity and stability. The system and method are particularly suited for monitoring of CO2 levels in oceans or other bodies of water.
Abstract translation: 提供分析物传感系统，利用分离和解耦的平衡和测量室提高灵敏度和稳定性。 该系统和方法特别适用于监测海洋或其他水体中的二氧化碳含量。
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公开(公告)号：EP2485636A4
公开(公告)日：2013-07-03
申请号：EP10822832
申请日：2010-10-12
Applicant: UNIV MARYLAND
Inventor： RAO GOVIND , KOSTOV YORDAN , TOLOSA LEAH , LAM HUNG
IPC: A61B5/00
CPC classification number: A61B5/015
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