公开(公告)号：ES2362797T3

公开(公告)日：2011-07-13

申请号：ES06851430

申请日：2006-08-18

Applicant: UNIV NORTHWESTERN

Inventor： MIRKIN CHAD ,  VEGA RAFAEL ,  MASPOCH DANIEL ,  SALAITA KHALID

IPC: G01N33/50

Abstract: Un arreglo que comprende: una superficie de sustrato, en donde la superficie del sustrato incluye sitios de enlazamiento para una partícula biológica y también sitios que no enlazan la partícula biológica, caracterizado porque dichos sitios de enlazamiento incluyen sitios de enlazamiento de iones metálicos, o sitios de enlazamiento para el metal catiónico divalente, en donde los sitios de enlazamiento sobre la superficie de sustrato tienen cada uno una forma y un tamaño; y una partícula biológica dispuesta sobre cada uno de los sitios de enlazamiento, caracterizada porque la partícula biológica es una proteína, un anticuerpo, o una célula.

公开(公告)号：WO2008020851A3

公开(公告)日：2008-04-24

申请号：PCT/US2006032316

申请日：2006-08-18

Applicant: UNIV NORTHWESTERN ,  MIRKIN CHAD A ,  VEGA RAFAEL A ,  MASPOCH DANIEL ,  SALAITA KHALID

Inventor： MIRKIN CHAD A ,  VEGA RAFAEL A ,  MASPOCH DANIEL ,  SALAITA KHALID

IPC: G01N33/543 ,  G01N33/553 ,  G01N33/569

CPC classification number: A61K31/70 ,  B82Y5/00 ,  B82Y30/00 ,  C12N7/00 ,  C12N2770/00011 ,  G01N33/56983 ,  Y10S977/802

Abstract: A novel coordination chemistry or metal ion binding approach to controlling the site- isolation and orientation of virus particles, such as TMV, on a nanoarray template generated by lithography including Dip Pen Nanolithography. By using the surface chemistry that is inherent in many viruses, metal-ion based or inorganic coordination chemistry was used to immobilize individual virus particles without the need for their genetic modification. Single particle control will enable a wide variety of studies involving viruses that are not possible with microarrays because of the size mismatch between the architecture of the virus and the features that make up such arrays. These include: single particle, single cell infectivity studies, the exploration of such structures as templates in materials synthesis and molecular electronics, and studies aimed at understanding how surface presentation can influence their bioactivity. This is a pioneering example of such control at the single-particle level, and therefore, commercial use of nanoarrays in biological systems.

Abstract translation: 一种新颖的配位化学或金属离子结合方法，用于控制病毒颗粒（如TMV）的位置分离和取向，通过平版印刷产生的纳米阵列模板，包括Dip Pen Nanoithography。 通过使用许多病毒固有的表面化学，使用金属离子或无机配位化学来固定个体病毒颗粒，而不需要进行遗传修饰。 由于病毒架构与组成这些阵列的特征之间的大小不匹配，单粒子控制将能够进行涉及病毒的各种研究，这些病毒是微不足道的。 这些包括：单粒子，单细胞感染性研究，材料合成和分子电子学模板等结构的探索，以及旨在了解表面呈现如何影响其生物活性的研究。 这是在单粒子水平上的这种控制的开创性例子，因此在生物系统中商业使用纳米阵列。

公开(公告)号：WO2008048305A3

公开(公告)日：2008-10-16

申请号：PCT/US2006046037

申请日：2006-12-04

Applicant: UNIV NORTHWESTERN ,  MIRKIN CHAD A ,  WANG YUHUANG ,  MASPOCH DANIEL

Inventor： MIRKIN CHAD A ,  WANG YUHUANG ,  MASPOCH DANIEL

IPC: B05D1/00 ,  C01B31/02 ,  H01L51/00

CPC classification number: B05D1/185 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  H01L51/0048 ,  Y10S977/742 ,  Y10S977/842 ,  Y10S977/845 ,  Y10S977/938 ,  Y10T428/24479 ,  Y10T428/249948 ,  Y10T428/26 ,  Y10T428/29 ,  Y10T428/2933 ,  Y10T428/2938 ,  Y10T428/2969 ,  Y10T428/30 ,  Y10T428/31

Abstract: Methods and articles providing for precise aligning, positioning, shaping, and linking of nanotubes and carbon nanotubes. An article comprising: a solid surface comprising at least two different surface regions including: a first surface region which comprises an outer boundary and which is adapted for carbon nanotube adsorption, and a second surface region which is adapted for preventing carbon nanotube adsorption, the second region forming an interface with the outer boundary of the first region, at least one carbon nanotube which is at least partially selectively adsorbed at the interface. The shape and size of the patterns on the surface and the length of the carbon nanotube can be controlled to provide for selective interfacial adsorption.

Abstract translation: 提供纳米管和碳纳米管的精确对准，定位，成形和连接的方法和制品。 一种制品，包括：包含至少两个不同表面区域的固体表面，包括：包含外边界并适于碳纳米管吸附的第一表面区域和适于防止碳纳米管吸附的第二表面区域，第二表面区域 形成与第一区域的外边界的界面的至少一个碳纳米管，其至少部分地选择性地吸附在界面处。 可以控制表面上的图案的形状和尺寸以及碳纳米管的长度以提供选择性界面吸附。

公开(公告)号：DE602006020747D1

公开(公告)日：2011-04-28

申请号：DE602006020747

申请日：2006-08-18

Applicant: UNIV NORTHWESTERN

Inventor： MIRKIN CHAD A ,  VEGA RAFAEL A ,  MASPOCH DANIEL ,  SALAITA KHALID

IPC: G01N33/50

公开(公告)号：AT502299T

公开(公告)日：2011-04-15

申请号：AT06851430

申请日：2006-08-18

Applicant: UNIV NORTHWESTERN

Inventor： MIRKIN CHAD ,  VEGA RAFAEL ,  MASPOCH DANIEL ,  SALAITA KHALID

IPC: G01N33/50

Abstract: A nanoarray template utilizing coordination chemistry or metal ion binding to control the site-isolation and orientation of virus particles is provided. The nanoarray template is generated by lithography including Dip Pen Nanolithography. The surface chemistry that is inherent in many viruses, metal-ion based or inorganic coordination chemistry is used to immobilize individual virus particles without the need for their genetic modification. Single particle control enables a wide variety of studies involving viruses that are not possible with microarrays, including single particle, single cell infectivity studies, exploration of such structures as templates in materials synthesis and molecular electronics, and studies aimed at understanding how surface presentation influences their bioactivity. This is an example of such control at the single-particle level, and therefore, commercial use of nanoarrays in biological systems.