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公开(公告)号：WO2022051847A1
公开(公告)日：2022-03-17
申请号：PCT/CA2021/051239
申请日：2021-09-08
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： FEHLINGS, Michael G. , KHAZAEI, Mohammad , AHUJA, Christopher S.
Abstract: Provided herein are methods of producing spNPCs from iPSCs or NPCs, cell populations, compositions comprising cell populations, and uses of spNPCs made using the methods described. The method can comprise: a. obtaining unpatterned NPCs, the unpatterned NPCs expressing neuroectodermal markers including Pax6 and Sox1; b. priming the unpatterned NPCs of step a; and c. patterning the primed unpatterned NPCs to produce spNPCS.
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公开(公告)号：WO2023010209A1
公开(公告)日：2023-02-09
申请号：PCT/CA2022/051178
申请日：2022-08-03
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： FEHLINGS, Michael George , KHAZAEI, Mohammad , AHUJA, Christopher S.
Abstract: The present disclosure relates generally to neural progenitor cells and therapeutic uses thereof. More particularly, the present disclosure provides cervical spinal cord-specific neural progenitor cells (cerNPCs), methods of producing cerNPCs, pharmaceutical compositions comprising cerNPCs, and methods of treating neurological diseases or disorders with the cerNPCs.
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公开(公告)号：EP4211229A1
公开(公告)日：2023-07-19
申请号：EP21865423.4
申请日：2021-09-08
Applicant: University Health Network
Inventor： FEHLINGS, Michael G. , KHAZAEI, Mohammad , AHUJA, Christopher S.
IPC: C12N5/0797 , A61K35/30 , A61P25/00 , A61P25/28 , C12N5/079
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公开(公告)号：EP4381051A1
公开(公告)日：2024-06-12
申请号：EP22851513.6
申请日：2022-08-03
Applicant: University Health Network
Inventor： FEHLINGS, Michael George , KHAZAEI, Mohammad , AHUJA, Christopher S.
CPC classification number: A61K35/30 , A61P25/28 , A61P25/00 , C07K14/4702 , C12N5/0619 , C12N2506/4520130101 , C12N2501/11520130101 , C12N2501/11920130101 , C12N2501/38520130101
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