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1.发明申请DEVICES AND PROCESSES FOR CHERENKOV-ACTIVATED NUCLEAR-TARGETED PHOTODYNAMIC THERAPY 审中-公开CHERENKOV激活的核靶光动力学疗法的装置和过程
公开(公告)号：WO2017197531A1
公开(公告)日：2017-11-23
申请号：PCT/CA2017/050614
申请日：2017-05-19
Inventor： WILSON, Brian , ALLEN, Christine
Abstract: Devices, materials, compounds, systems, and processes for Cherenkov-Activated Nuclear-Targeted Photodynamic Therapy that involves generating Cherenkov light within the tissue of a target volume and using this light to activate photosensitizing material that is located in the nucleus of cells of the target volume.
Abstract translation: Cherenkov激活的核靶向光动力疗法的设备，材料，化合物，系统和方法涉及在目标体积的组织内产生切伦科夫光并使用该光激活位于目标体内的光敏材料 在目标体积的细胞核中。
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2.发明申请IMAGEABLE ACTIVATABLE AGENT FOR RADIATION THERAPY AND METHOD AND SYSTEM FOR RADIATION THERAPY 审中-公开用于放射治疗的可成像的激活剂和用于放射治疗的方法和系统
公开(公告)号：WO2011137514A1
公开(公告)日：2011-11-10
申请号：PCT/CA2011/000513
申请日：2011-05-03
Applicant: UNIVERSITY HEALTH NETWORK , JAFFRAY, David A. , ALLEN, Christine , CHITHRANI, Devika , ZHENG, Jinzi , GRANT, Justin
Inventor： JAFFRAY, David A. , ALLEN, Christine , CHITHRANI, Devika , ZHENG, Jinzi , GRANT, Justin
CPC classification number: A61N5/00 , A61K9/0009 , A61K9/127 , A61K41/0028 , A61K41/0038 , A61K49/1812 , A61M31/005 , A61N5/10 , A61N2005/1094 , A61N2005/1098
Abstract: Imageable disruptable capsules containing a sensitizing agent or a protecting agent are used to enhance radiation therapy. Said capsules may be imaged by a non-invasive imaging modality, allowing for the determination of the precise timing to disrupt the capsule and release the sensitizing agent or protecting agent using an external energy source. This controlled and timed release of the sensitizing agent or protecting agent provides for enhanced radiation therapy by optimizing the delivery of the sensitizing agent or protecting agent to the target tissues. Systems comprising non-invasive imaging modalities, external energy sources and radiation energy sources are also taught for use with these imageable disruptable capsules.
Abstract translation: 使用含有敏化剂或保护剂的可成像的可破坏胶囊来增强放射治疗。 可以通过非侵入性成像模式对所述胶囊进行成像，从而允许确定干扰胶囊的精确时间并使用外部能量源释放敏化剂或保护剂。 敏感剂或保护剂的这种受控和定时的释放通过优化敏化剂或保护剂向目标组织的递送来提供增强的放射治疗。 还教导了包括非侵入性成像模式，外部能量源和辐射能源的系统与这些可成像的可破坏胶囊一起使用。
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公开(公告)号：WO2006084382A1
公开(公告)日：2006-08-17
申请号：PCT/CA2006/000207
申请日：2006-02-10
Applicant: UNIVERSITY HEALTH NETWORK , JAFFRAY, David , ALLEN, Christine , ZHENG, Jinzi , REILLY, Raymond Matthew , PERKINS, Gregory Jason
Inventor： JAFFRAY, David , ALLEN, Christine , ZHENG, Jinzi , REILLY, Raymond Matthew , PERKINS, Gregory Jason
CPC classification number: A61K49/04 , A61B5/055 , A61B5/415 , A61B5/418 , A61B6/00 , A61B6/5247 , A61B8/00 , A61B8/5238 , A61K9/127 , A61K9/1271 , A61K49/0002 , A61K49/0466 , A61K49/1812 , A61K51/1234
Abstract: Provided are signal modifying compositions for medical imaging comprising a carrier and two or more signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect to the signal modifying agents, which enables prolonged contrast imaging without significant depletion of the signal modifying agents from the carrier. The carriers of the present invention are lipid based or polymer based, the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal.
Abstract translation: 提供了用于医学成像的信号调节组合物，其包含载体和两种或更多种对两种或多种成像模态特异的信号调节剂。 组合物的特征在于相对于信号调节剂的保留效率，其使得能够延长对比度成像，而信号调节剂不会从载体中显着消耗。 本发明的载体是基于脂质或基于聚合物的，其物理化学性质可以被修饰以捕获或螯合不同的信号调节剂及其混合物，并靶向哺乳动物内的特定器官或肿瘤或组织。
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公开(公告)号：WO2014186909A1
公开(公告)日：2014-11-27
申请号：PCT/CA2014/050493
申请日：2014-05-26
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： ZHENG, Jinzi , ALLEN, Christine , JAFFRAY, David A.
IPC: A61K49/00
CPC classification number: A61K49/0466 , A61K49/0084
Abstract: The present application relates to compositions comprising an iodinated contrast agent and indocyanine green co-encapsulated inside a liposomal carrier, various uses thereof as well as methods for their preparation.
Abstract translation: 本申请涉及包含碘化造影剂和共同包封在脂质体载体内的吲哚菁绿的组合物，其各种用途以及它们的制备方法。
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公开(公告)号：EP3458155A1
公开(公告)日：2019-03-27
申请号：EP17798468.9
申请日：2017-05-19
Inventor： WILSON, Brian , ALLEN, Christine
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Patent Agency Ranking
公开(公告)号：EP3003396B1
公开(公告)日：2020-04-08
申请号：EP14800554.9
申请日：2014-05-26
Applicant: University Health Network
Inventor： ZHENG, Jinzi , ALLEN, Christine , JAFFRAY, David A.
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公开(公告)号：EP3003396A1
公开(公告)日：2016-04-13
申请号：EP14800554.9
申请日：2014-05-26
Applicant: University Health Network
Inventor： ZHENG, Jinzi , ALLEN, Christine , JAFFRAY, David A.
IPC: A61K49/00
Abstract: The present application relates to compositions comprising an iodinated contrast agent and indocyanine green co-encapsulated inside a liposomal carrier, various uses thereof as well as methods for their preparation.
Abstract translation: 本申请涉及包含在脂质体载体内共包封的碘化造影剂和吲哚菁绿的组合物，其各种用途以及它们的制备方法。
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公开(公告)号：EP1848464B1
公开(公告)日：2014-04-23
申请号：EP06705162.3
申请日：2006-02-10
Applicant: University Health Network
Inventor： JAFFRAY, David , ALLEN, Christine , ZHENG, Jinzi , REILLY, Raymond Matthew , PERKINS, Gregory Jason
IPC: A61K49/00 , A61K9/127 , A61B8/00 , A61B6/00 , A61B5/055 , A61K51/00 , A61B5/00 , A61K49/04 , A61K49/18 , A61K51/12 , A61B8/08
CPC classification number: A61K49/04 , A61B5/055 , A61B5/415 , A61B5/418 , A61B6/00 , A61B6/5247 , A61B8/00 , A61B8/5238 , A61K9/127 , A61K9/1271 , A61K49/0002 , A61K49/0466 , A61K49/1812 , A61K51/1234
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9.发明公开IMAGEABLE ACTIVATABLE AGENT FOR RADIATION THERAPY AND METHOD AND SYSTEM FOR RADIATION THERAPY 审中-公开可映射激活资金用于放射治疗和放射治疗制度和相关程序
公开(公告)号：EP2566522A1
公开(公告)日：2013-03-13
申请号：EP11777048.7
申请日：2011-05-03
Applicant: University Health Network
Inventor： JAFFRAY, David A. , ALLEN, Christine , CHITHRANI, Devika , ZHENG, Jinzi , GRANT, Justin
CPC classification number: A61N5/00 , A61K9/0009 , A61K9/127 , A61K41/0028 , A61K41/0038 , A61K49/1812 , A61M31/005 , A61N5/10 , A61N2005/1094 , A61N2005/1098
Abstract: Imageable disruptable capsules containing a sensitizing agent or a protecting agent are used to enhance radiation therapy. Said capsules may be imaged by a non-invasive imaging modality, allowing for the determination of the precise timing to disrupt the capsule and release the sensitizing agent or protecting agent using an external energy source. This controlled and timed release of the sensitizing agent or protecting agent provides for enhanced radiation therapy by optimizing the delivery of the sensitizing agent or protecting agent to the target tissues. Systems comprising non-invasive imaging modalities, external energy sources and radiation energy sources are also taught for use with these imageable disruptable capsules.
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公开(公告)号：EP1848464A1
公开(公告)日：2007-10-31
申请号：EP06705162.3
申请日：2006-02-10
Applicant: University Health Network
Inventor： JAFFRAY, David , ALLEN, Christine , ZHENG, Jinzi , REILLY, Raymond Matthew , PERKINS, Gregory Jason
CPC classification number: A61K49/04 , A61B5/055 , A61B5/415 , A61B5/418 , A61B6/00 , A61B6/5247 , A61B8/00 , A61B8/5238 , A61K9/127 , A61K9/1271 , A61K49/0002 , A61K49/0466 , A61K49/1812 , A61K51/1234
Abstract: Provided are signal modifying compositions for medical imaging comprising a carrier and two or more signal modifying agents specific for two or more imaging modalities. The compositions are characterized by retention efficiency, with respect to the signal modifying agents, which enables prolonged contrast imaging without significant depletion of the signal modifying agents from the carrier. The carriers of the present invention are lipid based or polymer based, the physico-chemical properties of which can be modified to entrap or chelate different signal modifying agents and mixtures thereof and to target specific organs or tumors or tissues within a mammal.
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