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公开(公告)号：WO2016090471A1
公开(公告)日：2016-06-16
申请号：PCT/CA2015/051282
申请日：2015-12-08
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： ZARRINE-AFSAR, Arash , JAFFRAY, David A.
CPC classification number: A61K49/106 , A61K49/00 , A61K49/0438 , G01N27/00 , G01N33/4833 , G01N33/58 , G01N2458/15 , G01N2560/00 , H01J49/0004 , H01J49/105
Abstract: Various embodiments are described herein for a system and a method for identifying a region of interest in tissue using mass spectrometry. An agent administration component can be provided to administer an exogenous agent to the tissue. A sampling unit can also be provided to acquire a sample from the tissue. The sample can then be provided to a high sensitivity analysis platform, such as a mass analyzer, to analyze the sample and determine a distribution of the exogenous agent or a by-product of the exogenous agent within the tissue based on the analysis. The analysis platform can then identify the region of interest based on the distribution of the exogenous agent or the distribution of the by-product.
Abstract translation: 本文描述了用于使用质谱法鉴定组织中的感兴趣区域的系统和方法的各种实施方案。 可以提供药剂施用组分以向组织施用外源性试剂。 还可以提供采样单元以从组织获取样品。 然后将样品提供给诸如质量分析仪的高灵敏度分析平台，以分析样品并基于分析确定组织内的外源性试剂或副产物的分布。 然后，分析平台可以基于外源性代理的分布或副产物的分布来识别感兴趣的区域。
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2.发明申请IMAGEABLE ACTIVATABLE AGENT FOR RADIATION THERAPY AND METHOD AND SYSTEM FOR RADIATION THERAPY 审中-公开用于放射治疗的可成像的激活剂和用于放射治疗的方法和系统
公开(公告)号：WO2011137514A1
公开(公告)日：2011-11-10
申请号：PCT/CA2011/000513
申请日：2011-05-03
Applicant: UNIVERSITY HEALTH NETWORK , JAFFRAY, David A. , ALLEN, Christine , CHITHRANI, Devika , ZHENG, Jinzi , GRANT, Justin
Inventor： JAFFRAY, David A. , ALLEN, Christine , CHITHRANI, Devika , ZHENG, Jinzi , GRANT, Justin
CPC classification number: A61N5/00 , A61K9/0009 , A61K9/127 , A61K41/0028 , A61K41/0038 , A61K49/1812 , A61M31/005 , A61N5/10 , A61N2005/1094 , A61N2005/1098
Abstract: Imageable disruptable capsules containing a sensitizing agent or a protecting agent are used to enhance radiation therapy. Said capsules may be imaged by a non-invasive imaging modality, allowing for the determination of the precise timing to disrupt the capsule and release the sensitizing agent or protecting agent using an external energy source. This controlled and timed release of the sensitizing agent or protecting agent provides for enhanced radiation therapy by optimizing the delivery of the sensitizing agent or protecting agent to the target tissues. Systems comprising non-invasive imaging modalities, external energy sources and radiation energy sources are also taught for use with these imageable disruptable capsules.
Abstract translation: 使用含有敏化剂或保护剂的可成像的可破坏胶囊来增强放射治疗。 可以通过非侵入性成像模式对所述胶囊进行成像，从而允许确定干扰胶囊的精确时间并使用外部能量源释放敏化剂或保护剂。 敏感剂或保护剂的这种受控和定时的释放通过优化敏化剂或保护剂向目标组织的递送来提供增强的放射治疗。 还教导了包括非侵入性成像模式，外部能量源和辐射能源的系统与这些可成像的可破坏胶囊一起使用。
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3.发明申请SENSORS WITH VIRTUAL SPATIAL SENSITIVITY FOR MONITORING A RADIATION GENERATING DEVICE 审中-公开具有虚拟空间灵敏度的传感器，用于监测辐射发生装置
公开(公告)号：WO2016191883A1
公开(公告)日：2016-12-08
申请号：PCT/CA2016/050635
申请日：2016-06-03
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： ISLAM, Mohammad Khairul , HEATON, Robert K. , JAFFRAY, David A. , NORRLINGER, Bernhard Dieter
Abstract: Various embodiments are described herein for sensors that may be used to measure radiation from radiation generating device. The sensors may use a collector plate electrode with first and second collection regions having shapes that are inversely related with one another to provide ion chambers with varying sample volumes along a substantial portion of the first and second collection regions which provides virtual spatial sensitivity during use.
Abstract translation: 本文描述了可用于测量来自辐射发生装置的辐射的传感器的各种实施例。 传感器可以使用具有第一和第二收集区域的收集板电极，该第一和第二收集区域具有彼此负相关的形状，以提供具有沿第一和第二收集区域的实质部分变化的样品体积的离子室，其在使用期间提供虚拟空间灵敏度。
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公开(公告)号：WO2014186909A1
公开(公告)日：2014-11-27
申请号：PCT/CA2014/050493
申请日：2014-05-26
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： ZHENG, Jinzi , ALLEN, Christine , JAFFRAY, David A.
IPC: A61K49/00
CPC classification number: A61K49/0466 , A61K49/0084
Abstract: The present application relates to compositions comprising an iodinated contrast agent and indocyanine green co-encapsulated inside a liposomal carrier, various uses thereof as well as methods for their preparation.
Abstract translation: 本申请涉及包含碘化造影剂和共同包封在脂质体载体内的吲哚菁绿的组合物，其各种用途以及它们的制备方法。
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公开(公告)号：WO2017139899A1
公开(公告)日：2017-08-24
申请号：PCT/CA2017/050213
申请日：2017-02-17
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： JAFFRAY, David A. , WOUTERS, Bradly G. , JAFFRAY, Alexander Ralph Lino , ELLIOTT, Ryan Steven
CPC classification number: C12M1/34 , C12M1/42 , C12M41/48 , G01N33/5011 , G01N2510/00 , G01N2800/40 , G01N2800/52 , G06F19/00 , G21K5/08
Abstract: A high throughput automated assay platform for temporal image processing of cell growth and colony formation before and after radiation therapy treatments. The platform is designed to compute and monitor a therapeutic protocol by measuring sensitivity of cell growth to treatment based on a radiation therapy protocol. The platform is designed to detect relationships between the temporal images being tracked to colony formation behaviour.
Abstract translation: 高通量自动化测定平台，用于在放射疗法治疗之前和之后进行细胞生长和集落形成的时间图像处理。 该平台设计用于通过测量基于放射治疗方案的细胞生长对治疗的敏感性来计算和监测治疗方案。 该平台旨在检测跟踪的时间图像与群体形成行为之间的关系。
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Patent Agency Ranking
公开(公告)号：WO2017049403A1
公开(公告)日：2017-03-30
申请号：PCT/CA2016/051112
申请日：2016-09-22
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： ZARRINE-AFSAR, Arash , JAFFRAY, David A. , TATA, Alessandra , WOOLMAN, Michael , VITKIN, I. Alex
CPC classification number: G01N21/21 , A61B10/0233 , A61B18/20 , H01J49/0004
Abstract: Various embodiments are described herein for a system and a method for obtaining samples of tissue for analysis by mass spectrometry. A region of interest can be identified in tissue using image data from a first imaging modality that is other than mass spectrometry. At least one tissue sample can be acquired using a tissue sampler from a sampling location related to the region of interest. Mass spectrum data can be generated for the acquired tissue samples using a mass spectrometer. In some embodiments, polarimetry may be used on a tissue slice, mass spectrometry may be performed on the same tissue slice and then H&E imaging may be performed on the same tissue slice.
Abstract translation: 本文描述了用于通过质谱法获得用于分析的组织样品的系统和方法。 可以使用来自不同于质谱的第一成像模态的图像数据在组织中鉴定感兴趣区域。 可以使用来自与感兴趣区域相关的采样位置的组织取样器获取至少一个组织样本。 可以使用质谱仪对采集的组织样品产生质谱数据。 在一些实施例中，可以在组织切片上使用偏振测定法，可以在相同的组织切片上进行质谱分析，然后可以在相同的组织切片上进行H＆E成像。
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公开(公告)号：EP3003396B1
公开(公告)日：2020-04-08
申请号：EP14800554.9
申请日：2014-05-26
Applicant: University Health Network
Inventor： ZHENG, Jinzi , ALLEN, Christine , JAFFRAY, David A.
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8.发明公开SENSORS WITH VIRTUAL SPATIAL SENSITIVITY FOR MONITORING A RADIATION GENERATING DEVICE 审中-公开具有虚拟空间灵敏度的传感器监测辐射发生装置
公开(公告)号：EP3304127A1
公开(公告)日：2018-04-11
申请号：EP16802303.4
申请日：2016-06-03
Applicant: University Health Network (UHN)
Inventor： ISLAM, Mohammad Khairul , HEATON, Robert K. , JAFFRAY, David A. , NORRLINGER, Bernhard Dieter
CPC classification number: G01T1/185 , G01T1/2935 , H01J47/02
Abstract: Various embodiments are described herein for sensors that may be used to measure radiation from radiation generating device. The sensors may use a collector plate electrode with first and second collection regions having shapes that are inversely related with one another to provide ion chambers with varying sample volumes along a substantial portion of the first and second collection regions which provides virtual spatial sensitivity during use.
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9.发明授权RETROSPECTIVE SORTING OF 4D CT INTO BREATHING PHASES BASED ON GEOMETRIC ANALYSIS OF IMAGING FIDUCIALS 有权插图报酬4D CAT检查在呼吸阶段RETROSPECTIVE分拣基于几何分析
公开(公告)号：EP2024931B1
公开(公告)日：2015-12-30
申请号：EP07761619.1
申请日：2007-05-01
Applicant: Koninklijke Philips N.V. , University Health Network
Inventor： JAFFRAY, David A. , KAUS, Michael R. , HOISAK, Jeremy D. P. , PURDIE, Thomas G.
CPC classification number: A61B90/39 , A61B5/7289 , A61B6/12 , A61B6/5217 , A61B2090/376 , A61B2090/392 , G06T7/73 , G06T11/005 , G06T2207/10076 , G06T2207/30004 , G06T2211/412
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公开(公告)号：EP3003396A1
公开(公告)日：2016-04-13
申请号：EP14800554.9
申请日：2014-05-26
Applicant: University Health Network
Inventor： ZHENG, Jinzi , ALLEN, Christine , JAFFRAY, David A.
IPC: A61K49/00
Abstract: The present application relates to compositions comprising an iodinated contrast agent and indocyanine green co-encapsulated inside a liposomal carrier, various uses thereof as well as methods for their preparation.
Abstract translation: 本申请涉及包含在脂质体载体内共包封的碘化造影剂和吲哚菁绿的组合物，其各种用途以及它们的制备方法。
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