公开(公告)号：WO2014056083A1

公开(公告)日：2014-04-17

申请号：PCT/CA2013/000859

申请日：2013-10-11

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： LIU, Yong ,  LANG, Yunhui ,  NG, Grace ,  LI, Sze-Wan ,  PAULS, Heinz W. ,  LAUFER, Radoslaw ,  PATEL, Narendra Kumar B. ,  SAMPSON, Peter Brent ,  FEHER, Miklos ,  AWREY, Donald E.

IPC: C07D451/06 ,  A61K31/416 ,  A61K31/4439 ,  A61P35/00 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D498/08

CPC classification number: C07D498/08 ,  C07D231/56 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D451/06

Abstract: The invention is a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. Values for the variables are provided herein. Also included is a pharmaceutical composition comprising the compound represented by Structural Formula (I) and a pharmaceutically acceptable carrier or diluent and methods of treating a subject with cancer with the compound of Structural Formula (I).

Abstract translation: 本发明是由结构式（I）表示的化合物或其药学上可接受的盐。 这里提供了变量的值。 还包括药物组合物，其包含由结构式（I）表示的化合物和药学上可接受的载体或稀释剂以及用结构式（I）的化合物治疗患有癌症的受试者的方法。

公开(公告)号：WO2013053051A1

公开(公告)日：2013-04-18

申请号：PCT/CA2012/000955

申请日：2012-10-12

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： PAULS, Heinz W. ,  LAUFER, Radoslaw ,  LIU, Yong ,  LI, Sze-Wan ,  FORREST, Bryan T. ,  LANG, Yunhui ,  PATEL, Narendra Kumar B. ,  EDWARDS, Louise G. ,  NG, Grace ,  SAMPSON, Peter Brent ,  FEHER, Miklos ,  AWREY, Donald E.

IPC: C07D401/00 ,  A61K31/416 ,  A61P35/00 ,  C07D231/56 ,  C07D401/02 ,  C07D401/14 ,  C07D403/02 ,  C07D405/14 ,  C07D409/14 ,  C07D451/06 ,  C07D491/107

CPC classification number: C07D231/56 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  C07D451/06 ,  C07D491/107 ,  C07D493/10

Abstract: The present teaching provide indazole compounds represented by Structural Formulae (I) or (I') or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof as protein kinase inhibitors, such as TTK protein kinase, polo-like kinase 4 (PLK4) and Aurora kinases having anticancer activity against breast cancer cells, colon cancer cells, and ovarian cancer cells.

Abstract translation: 本教导提供由结构式（I）或（I'）表示的吲唑化合物或其药学上可接受的盐。 还描述了作为蛋白激酶抑制剂的药物组合物及其使用方法，例如对乳腺癌细胞，结肠癌细胞和卵巢癌细胞具有抗癌活性的TTK蛋白激酶，polo样激酶4（PLK4）和Aurora激酶。

公开(公告)号：EP2766352A1

公开(公告)日：2014-08-20

申请号：EP12840107.2

申请日：2012-10-12

Applicant: University Health Network (UHN)

Inventor： PAULS, Heinz W. ,  LAUFER, Radoslaw ,  LIU, Yong ,  LI, Sze-Wan ,  FORREST, Bryan T. ,  LANG, Yunhui ,  PATEL, Narendra Kumar B. ,  EDWARDS, Louise G. ,  NG, Grace ,  SAMPSON, Peter Brent ,  FEHER, Miklos ,  AWREY, Donald E.

IPC: C07D401/00 ,  A61K31/416 ,  A61P35/00 ,  C07D231/56 ,  C07D401/02 ,  C07D401/14 ,  C07D403/02 ,  C07D405/14 ,  C07D409/14 ,  C07D451/06 ,  C07D491/107

CPC classification number: C07D231/56 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  C07D451/06 ,  C07D491/107 ,  C07D493/10

Abstract: The present teaching provide indazole compounds represented by Structural Formulae (I) or (I') or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof as protein kinase inhibitors, such as TTK protein kinase, polo-like kinase 4 (PLK4) and Aurora kinases having anticancer activity against breast cancer cells, colon cancer cells, and ovarian cancer cells.

公开(公告)号：EP2766352B1

公开(公告)日：2018-06-06

申请号：EP12840107.2

申请日：2012-10-12

Applicant: University Health Network (UHN)

Inventor： PAULS, Heinz W. ,  LAUFER, Radoslaw ,  LIU, Yong ,  LI, Sze-Wan ,  FORREST, Bryan T. ,  LANG, Yunhui ,  PATEL, Narendra Kumar B. ,  EDWARDS, Louise G. ,  NG, Grace ,  SAMPSON, Peter Brent ,  FEHER, Miklos ,  AWREY, Donald E.

IPC: C07D409/12 ,  C07D409/14 ,  C07D231/56 ,  C07D401/12 ,  C07D401/14 ,  C07D401/10 ,  C07D413/14 ,  C07D413/04 ,  C07D413/10 ,  C07D405/14 ,  C07D451/06 ,  C07D491/107 ,  C07D493/10 ,  A61K31/416 ,  A61P35/00

CPC classification number: C07D231/56 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  C07D451/06 ,  C07D491/107 ,  C07D493/10

Abstract: The present teachings provide a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.