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1.发明申请INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME 审中-公开作为激酶抑制剂的INDAZOLE化合物和与其相同治疗癌症的方法
公开(公告)号：WO2013053051A1
公开(公告)日：2013-04-18
申请号：PCT/CA2012/000955
申请日：2012-10-12
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： PAULS, Heinz W. , LAUFER, Radoslaw , LIU, Yong , LI, Sze-Wan , FORREST, Bryan T. , LANG, Yunhui , PATEL, Narendra Kumar B. , EDWARDS, Louise G. , NG, Grace , SAMPSON, Peter Brent , FEHER, Miklos , AWREY, Donald E.
IPC: C07D401/00 , A61K31/416 , A61P35/00 , C07D231/56 , C07D401/02 , C07D401/14 , C07D403/02 , C07D405/14 , C07D409/14 , C07D451/06 , C07D491/107
CPC classification number: C07D231/56 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D451/06 , C07D491/107 , C07D493/10
Abstract: The present teaching provide indazole compounds represented by Structural Formulae (I) or (I') or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof as protein kinase inhibitors, such as TTK protein kinase, polo-like kinase 4 (PLK4) and Aurora kinases having anticancer activity against breast cancer cells, colon cancer cells, and ovarian cancer cells.
Abstract translation: 本教导提供由结构式（I）或（I'）表示的吲唑化合物或其药学上可接受的盐。 还描述了作为蛋白激酶抑制剂的药物组合物及其使用方法，例如对乳腺癌细胞，结肠癌细胞和卵巢癌细胞具有抗癌活性的TTK蛋白激酶，polo样激酶4（PLK4）和Aurora激酶。
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公开(公告)号：WO2012048411A1
公开(公告)日：2012-04-19
申请号：PCT/CA2011/001144
申请日：2011-10-13
Applicant: UNIVERSITY HEALTH NETWORK , PAULS, Heinz, W. , LI, Sze-Wan , SAMPSON, Peter Brent , FORREST, Bryan T.
Inventor： PAULS, Heinz, W. , LI, Sze-Wan , SAMPSON, Peter Brent , FORREST, Bryan T.
IPC: C07D403/04 , A61K31/416 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/5386 , A61P35/00 , C07D401/14 , C07D403/14 , C07D413/14 , C07D498/08 , C12N9/12
CPC classification number: C07D403/10 , C07D401/14 , C07D403/14 , C07D413/14 , C07D498/08
Abstract: The invention is directed to a compound represented by the following Structural Formula (I) and (II) and pharmaceutically acceptable salts thereof: (Formula (I)); (Formula (IV)). Compounds represented by this structural formula are kinase inhibitors and are, therefore, disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
Abstract translation: 本发明涉及由以下结构式（I）和（II）表示的化合物及其药学上可接受的盐：（式（I））; （式（IV））。 由该结构式表示的化合物是激酶抑制剂，因此在本文中公开用于治疗癌症。 本文提供了结构式中变量的定义。
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公开(公告)号：WO2011123946A1
公开(公告)日：2011-10-13
申请号：PCT/CA2011/000386
申请日：2011-04-06
Applicant: UNIVERSITY HEALTH NETWORK , SAMPSON, Peter Brent , LIU, Yong , LI, Sze-Wan , FORREST, Bryan T. , PAULS, Heinz W. , EDWARDS, Louise G. , FEHER, Miklos , PATEL, Narendra Kumar B. , LAUFER, Radoslaw , PAN, Guohua
Inventor： SAMPSON, Peter Brent , LIU, Yong , LI, Sze-Wan , FORREST, Bryan T. , PAULS, Heinz W. , EDWARDS, Louise G. , FEHER, Miklos , PATEL, Narendra Kumar B. , LAUFER, Radoslaw , PAN, Guohua
IPC: C07D413/14 , A61K31/5377 , A61P35/00 , C07D403/04
CPC classification number: C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The invention is directed to a compound represented by the following structural formula pharmaceutically acceptable salts thereof: (I). Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
Abstract translation: 本发明涉及由以下结构式表示的化合物其药学上可接受的盐：（I）。 由该结构式表示的化合物是激酶抑制剂，因此在此公开用于治疗癌症。 本文提供了结构式中变量的定义。
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公开(公告)号：WO2010115279A1
公开(公告)日：2010-10-14
申请号：PCT/CA2010/000518
申请日：2010-04-06
Applicant: UNIVERSITY HEALTH NETWORK , SAMPSON, Peter Brent , Ll, Sze-Wan , LIU, Yong , PAULS, Heinz W. , EDWARDS, Louise G. , FORREST, Bryan T. , FEHER, Miklos , PATEL, Narendra Kumar B. , PAN, Guohua
Inventor： SAMPSON, Peter Brent , Ll, Sze-Wan , LIU, Yong , PAULS, Heinz W. , EDWARDS, Louise G. , FORREST, Bryan T. , FEHER, Miklos , PATEL, Narendra Kumar B. , PAN, Guohua
IPC: C07D403/04 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61P35/00 , C07D401/14 , C07D409/14 , C07D413/14
CPC classification number: A61K31/553 , A61K31/416 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/10
Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
Abstract translation: 本发明涉及由以下结构式表示的化合物及其药学上可接受的盐：由该结构式表示的化合物是激酶抑制剂，因此本文公开了用于治疗癌症的化合物。 本文提供了结构式中变量的定义。
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5.发明公开
公开(公告)号：EP2766352A1
公开(公告)日：2014-08-20
申请号：EP12840107.2
申请日：2012-10-12
Applicant: University Health Network (UHN)
Inventor： PAULS, Heinz W. , LAUFER, Radoslaw , LIU, Yong , LI, Sze-Wan , FORREST, Bryan T. , LANG, Yunhui , PATEL, Narendra Kumar B. , EDWARDS, Louise G. , NG, Grace , SAMPSON, Peter Brent , FEHER, Miklos , AWREY, Donald E.
IPC: C07D401/00 , A61K31/416 , A61P35/00 , C07D231/56 , C07D401/02 , C07D401/14 , C07D403/02 , C07D405/14 , C07D409/14 , C07D451/06 , C07D491/107
CPC classification number: C07D231/56 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D451/06 , C07D491/107 , C07D493/10
Abstract: The present teaching provide indazole compounds represented by Structural Formulae (I) or (I') or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof as protein kinase inhibitors, such as TTK protein kinase, polo-like kinase 4 (PLK4) and Aurora kinases having anticancer activity against breast cancer cells, colon cancer cells, and ovarian cancer cells.
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Patent Agency Ranking
公开(公告)号：EP2766352B1
公开(公告)日：2018-06-06
申请号：EP12840107.2
申请日：2012-10-12
Applicant: University Health Network (UHN)
Inventor： PAULS, Heinz W. , LAUFER, Radoslaw , LIU, Yong , LI, Sze-Wan , FORREST, Bryan T. , LANG, Yunhui , PATEL, Narendra Kumar B. , EDWARDS, Louise G. , NG, Grace , SAMPSON, Peter Brent , FEHER, Miklos , AWREY, Donald E.
IPC: C07D409/12 , C07D409/14 , C07D231/56 , C07D401/12 , C07D401/14 , C07D401/10 , C07D413/14 , C07D413/04 , C07D413/10 , C07D405/14 , C07D451/06 , C07D491/107 , C07D493/10 , A61K31/416 , A61P35/00
CPC classification number: C07D231/56 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D451/06 , C07D491/107 , C07D493/10
Abstract: The present teachings provide a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.
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公开(公告)号：EP2556071B1
公开(公告)日：2016-08-17
申请号：EP11764988.9
申请日：2011-04-06
Applicant: University Health Network
Inventor： SAMPSON, Peter Brent , LIU, Yong , LI, Sze-Wan , FORREST, Bryan T. , PAULS, Heinz W. , EDWARDS, Louise G. , FEHER, Miklos , PATEL, Narendra Kumar B. , LAUFER, Radoslaw , PAN, Guohua
IPC: C07D413/14 , A61K31/5377 , A61P35/00 , C07D403/04 , C07D403/10 , C07D403/14
CPC classification number: C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
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公开(公告)号：EP2417127B1
公开(公告)日：2014-02-26
申请号：EP10761154.3
申请日：2010-04-06
Applicant: University Health Network
Inventor： SAMPSON, Peter Brent , Ll, Sze-Wan , LIU, Yong , PAULS, Heinz W. , EDWARDS, Louise G. , FORREST, Bryan T. , FEHER, Miklos , PATEL, Narendra Kumar B. , PAN, Guohua
IPC: C07D403/04 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61P35/00 , C07D401/14 , C07D409/14 , C07D413/14 , C07D403/14 , C07D471/14 , C07D471/04
CPC classification number: A61K31/553 , A61K31/416 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/10
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公开(公告)号：EP2556071A1
公开(公告)日：2013-02-13
申请号：EP11764988.9
申请日：2011-04-06
Applicant: University Health Network
Inventor： SAMPSON, Peter Brent , LIU, Yong , LI, Sze-Wan , FORREST, Bryan T. , PAULS, Heinz W. , EDWARDS, Louise G. , FEHER, Miklos , PATEL, Narendra Kumar B. , LAUFER, Radoslaw , PAN, Guohua
IPC: C07D413/14 , A61K31/5377 , A61P35/00 , C07D403/04
CPC classification number: C07D403/10 , A61K31/5377 , A61K45/06 , C07D231/56 , C07D403/04 , C07D403/14 , C07D413/14
Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
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公开(公告)号：EP2417127A1
公开(公告)日：2012-02-15
申请号：EP10761154.3
申请日：2010-04-06
Applicant: University Health Network
Inventor： SAMPSON, Peter Brent , Ll, Sze-Wan , LIU, Yong , PAULS, Heinz W. , EDWARDS, Louise G. , FORREST, Bryan T. , FEHER, Miklos , PATEL, Narendra Kumar B. , PAN, Guohua
IPC: C07D403/04 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61P35/00 , C07D401/14 , C07D409/14 , C07D413/14
CPC classification number: A61K31/553 , A61K31/416 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/10
Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.
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