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1.发明申请METHODS, COMPOUNDS AND COMPOSITIONS FOR MODULATING BLOOD BRAIN BARRIER INTEGRITY AND RE-MYELINATION 审中-公开方法，化合物和组合物，用于调节血液脑阻滞剂的完整性和再释放
公开(公告)号：WO2017049411A1
公开(公告)日：2017-03-30
申请号：PCT/CA2016/051122
申请日：2016-09-23
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： MONNIER, Philippe Patrick , TASSEW, Nardos G. , BAGLAENKO, Yuriy
CPC classification number: A61K38/179 , A61K38/1709 , A61K39/395 , C07K14/47
Abstract: Disclosed herein are methods and compositions for increasing and decreasing the permeability of the blood brain barrier for the treatment of diseases and conditions and to facilitate the delivery of agents to the brain, as well as methods and compositions for promoting re-myelination and preventing de-myelination. Compositions include RGMa, soluble RGMa, and functional fragments and variants thereof, RGMc, soluble RGMc, and functional fragments and variants thereof, and Neogenin peptides including 4Ig.
Abstract translation: 本文公开了用于增加和减少用于治疗疾病和病症的血脑屏障的渗透性并促进药物递送至脑的方法和组合物，以及用于促进再髓鞘化和预防脱发的方法和组合物， 髓鞘形成。 组合物包括RGMa，可溶性RGMa及其功能片段及其变体，RGMc，可溶性RGMc及其功能片段及变体，以及包含4Ig的Neogenin肽。
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2.发明公开
公开(公告)号：EP3352778A1
公开(公告)日：2018-08-01
申请号：EP16847698.4
申请日：2016-09-23
Applicant: University Health Network
Inventor： MONNIER, Philippe Patrick , TASSEW, Nardos G. , BAGLAENKO, Yuriy
CPC classification number: A61K38/1709 , A61K38/179 , A61K39/395 , A61K49/00 , A61P21/00 , A61P25/14 , A61P25/28 , C07K14/47
Abstract: Disclosed herein are methods and compositions for increasing and decreasing the permeability of the blood brain barrier for the treatment of diseases and conditions and to facilitate the delivery of agents to the brain, as well as methods and compositions for promoting re-myelination and preventing de-myelination. Compositions include RGMa, soluble RGMa, and functional fragments and variants thereof, RGMc, soluble RGMc, and functional fragments and variants thereof, and Neogenin peptides including 4Ig.
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