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公开(公告)号：WO2020163962A1
公开(公告)日：2020-08-20
申请号：PCT/CA2020/050195
申请日：2020-02-14
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： BROKX, Richard , MASON, Jacqueline M. , BRAY, Mark R.
IPC: C07K16/28 , A61K39/395 , A61P31/00 , A61P35/00 , A61P35/02 , A61P37/02 , C12N15/13 , C12N5/10 , C12P21/08
Abstract: The invention provides novel anti-FCMR antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer or autoimmune disease.
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公开(公告)号：WO2022187968A1
公开(公告)日：2022-09-15
申请号：PCT/CA2022/050363
申请日：2022-03-11
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： BROKX, Richard , MASON, Jacqueline M. , BRAY, Mark Robert , DUNCAN, Gordon S.
Abstract: The invention provides novel anti-LILR antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer, autoimmune disease, or allergic inflammation.
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公开(公告)号：WO2020146946A1
公开(公告)日：2020-07-23
申请号：PCT/CA2020/050042
申请日：2020-01-16
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： BROKX, Richard , MASON, Jacqueline M. , BRAY, Mark R.
IPC: C07K16/28 , A61K39/395 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , C12N15/13 , C12P21/08
Abstract: The invention provides novel anti-LILRB3 antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer, autoimmune disease, or allergic inflammation. This invention can also be used to modulate osteoclast differentiation.
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公开(公告)号：WO2020181376A1
公开(公告)日：2020-09-17
申请号：PCT/CA2020/050321
申请日：2020-03-11
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： BROKX, Richard , MASON, Jacqueline M. , BRAY, Mark R.
IPC: C07K16/18 , A61K39/395 , C12N15/13 , C12P21/08
Abstract: The invention provides novel anti-TSG-6 antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer or autoimmune disease.
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公开(公告)号：WO2016065461A1
公开(公告)日：2016-05-06
申请号：PCT/CA2015/051024
申请日：2015-10-09
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： LAUFER, Radoslaw , NG, Grace , BROKX, Richard , PAULS, Heinz W. , LI, Sze-wan , MASON, Jacqueline M. , BRAY, Mark R.
IPC: C07D487/04 , A61K31/519 , A61P29/00 , A61P35/00 , A61P37/06
CPC classification number: A61K31/519 , A61K45/06 , C07D487/04
Abstract: The invention is a compound represented by Structural Formula (I): (I); or a pharmaceutically acceptable salt thereof. Values for the variables are provided herein. Also included is a pharmaceutical composition comprising the compound represented by Structural Formula (I) and a pharmaceutically acceptable carrier or diluent and methods of treating a subject with cancer with the compound of Structural Formula (I).
Abstract translation: 本发明是由结构式（I）表示的化合物：（I）; 或其药学上可接受的盐。 这里提供了变量的值。 还包括药物组合物，其包含由结构式（I）表示的化合物和药学上可接受的载体或稀释剂以及用结构式（I）的化合物治疗患有癌症的受试者的方法。
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Patent Agency Ranking
公开(公告)号：EP3212652A1
公开(公告)日：2017-09-06
申请号：EP15855932.8
申请日：2015-10-09
Applicant: University Health Network
Inventor： LAUFER, Radoslaw , NG, Grace , BROKX, Richard , PAULS, Heinz W. , LI, Sze-wan , MASON, Jacqueline M. , BRAY, Mark R.
IPC: C07D487/04 , A61K31/519 , A61P29/00 , A61P35/00 , A61P37/06
CPC classification number: A61K31/519 , A61K45/06 , C07D487/04
Abstract: The invention is a compound represented by Structural Formula (I): (I); or a pharmaceutically acceptable salt thereof. Values for the variables are provided herein. Also included is a pharmaceutical composition comprising the compound represented by Structural Formula (I) and a pharmaceutically acceptable carrier or diluent and methods of treating a subject with cancer with the compound of Structural Formula (I).
Abstract translation: 本发明是由结构式（I）表示的化合物：（I）; 或其药学上可接受的盐。 这里提供了变量的值。 还包括包含由结构式（I）表示的化合物和药学上可接受的载体或稀释剂的药物组合物以及用结构式（I）的化合物治疗患有癌症的个体的方法。
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公开(公告)号：EP3924388A1
公开(公告)日：2021-12-22
申请号：EP20756467.5
申请日：2020-02-14
Applicant: University Health Network
Inventor： BROKX, Richard , MASON, Jacqueline M. , BRAY, Mark R.
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公开(公告)号：EP4305068A1
公开(公告)日：2024-01-17
申请号：EP22766049.5
申请日：2022-03-11
Applicant: University Health Network
Inventor： BROKX, Richard , MASON, Jacqueline M. , BRAY, Mark Robert , DUNCAN, Gordon S.
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公开(公告)号：EP3938389A1
公开(公告)日：2022-01-19
申请号：EP20769649.3
申请日：2020-03-11
Applicant: University Health Network
Inventor： BROKX, Richard , MASON, Jacqueline M. , BRAY, Mark R.
IPC: C07K16/18 , A61K39/395 , C12N15/13 , C12P21/08
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公开(公告)号：EP3911680A1
公开(公告)日：2021-11-24
申请号：EP20741290.9
申请日：2020-01-16
Applicant: University Health Network
Inventor： BROKX, Richard , MASON, Jacqueline M. , BRAY, Mark R.
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