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公开(公告)号：WO2022187968A1
公开(公告)日：2022-09-15
申请号：PCT/CA2022/050363
申请日：2022-03-11
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： BROKX, Richard , MASON, Jacqueline M. , BRAY, Mark Robert , DUNCAN, Gordon S.
Abstract: The invention provides novel anti-LILR antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer, autoimmune disease, or allergic inflammation.
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Patent Agency Ranking
公开(公告)号：WO2020215155A8
公开(公告)日：2020-10-29
申请号：PCT/CA2020/050535
申请日：2020-04-23
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： LI, Sze-wan , BRAY, Mark Robert
IPC: C07D413/10 , A61K31/191 , A61K31/5377 , A61P35/00 , C07C57/15
Abstract: Disclosed is Crystal Form S4 of a fumarate salt of compound (I) represented by the following structural formula: (I) The molar ratio between compound (I) and fumaric acid is 1.0:1:0. Crystal Form S4, 5 characterized by an X-ray powder diffraction pattern which comprises peaks at 6.6°, 9.8°, 16.3°, 21.1°, 28.7°, and 30.2° ± 0.2 in 2θ.
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公开(公告)号：WO2019023799A1
公开(公告)日：2019-02-07
申请号：PCT/CA2018/050936
申请日：2018-08-01
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： BRAY, Mark Robert , MASON, Jacqueline M. , MAK, Tak W. , FLETCHER, Graham
IPC: A61K31/519 , A61K39/395 , A61P35/00 , C07D487/04 , C07K16/18
Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.
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公开(公告)号：WO2019023786A1
公开(公告)日：2019-02-07
申请号：PCT/CA2017/050920
申请日：2017-08-01
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： BRAY, Mark Robert , MASON, Jacqueline M. , MAK, Tak W. , FLETCHER, Graham
IPC: A61K31/519 , A61K39/395 , A61P35/00 , A61P37/02 , C07D487/04 , C07K16/28 , C07K16/30
Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.
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公开(公告)号：EP3959209A1
公开(公告)日：2022-03-02
申请号：EP20795605.3
申请日：2020-04-23
Applicant: University Health Network
Inventor： LI, Sze-wan , BRAY, Mark Robert
IPC: C07D413/10 , A61K31/191 , A61K31/5377 , A61P35/00 , C07C57/15
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公开(公告)号：EP4305068A1
公开(公告)日：2024-01-17
申请号：EP22766049.5
申请日：2022-03-11
Applicant: University Health Network
Inventor： BROKX, Richard , MASON, Jacqueline M. , BRAY, Mark Robert , DUNCAN, Gordon S.
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