公开(公告)号：WO2015051447A1

公开(公告)日：2015-04-16

申请号：PCT/CA2014/000733

申请日：2014-10-07

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： SCHIMMER, Aaron David ,  BUHAJCZUK, Dannie

IPC: C07D311/58 ,  A61K31/352 ,  A61K36/48 ,  A61P35/00 ,  C07D311/22

CPC classification number: A61K31/352 ,  A61K31/337 ,  A61K31/475 ,  A61K36/48 ,  A61K45/06 ,  C07D311/22 ,  C07D311/58 ,  A61K2300/00

Abstract: A compound of Formula I and/or II and/or a composition comprising a compound of Formula I and/or II is described as well as uses of said compounds and compositions for inhibiting microtubule polymerization, inducing lysosome disruption and/or treating a cancer, including a hematological cancer such as leukemia.

Abstract translation: 描述式I和/或II化合物和/或包含式I和/或II化合物的组合物以及所述化合物和组合物用于抑制微管聚合，诱导溶酶体破坏和/或治疗癌症的用途， 包括血液癌症如白血病。