公开(公告)号：WO2021155479A1

公开(公告)日：2021-08-12

申请号：PCT/CA2021/050138

申请日：2021-02-08

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： ZHANG, Li ,  LEE, Jong Bok ,  SCHIMMER, Aaron David

IPC: C12N5/0783 ,  A61K31/437 ,  A61K35/17 ,  A61P35/00 ,  A61P35/02 ,  C07D471/04

Abstract: Methods of treating T cells with Venetoclax to increase T cell-mediated cytotoxicity and/or T cell mediated anti-tumor activity are described. Also described are populations of enhanced T cells as well as associated methods and uses for the treatment of cancer.

公开(公告)号：WO2015051447A1

公开(公告)日：2015-04-16

申请号：PCT/CA2014/000733

申请日：2014-10-07

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： SCHIMMER, Aaron David ,  BUHAJCZUK, Dannie

IPC: C07D311/58 ,  A61K31/352 ,  A61K36/48 ,  A61P35/00 ,  C07D311/22

CPC classification number: A61K31/352 ,  A61K31/337 ,  A61K31/475 ,  A61K36/48 ,  A61K45/06 ,  C07D311/22 ,  C07D311/58 ,  A61K2300/00

Abstract: A compound of Formula I and/or II and/or a composition comprising a compound of Formula I and/or II is described as well as uses of said compounds and compositions for inhibiting microtubule polymerization, inducing lysosome disruption and/or treating a cancer, including a hematological cancer such as leukemia.

Abstract translation: 描述式I和/或II化合物和/或包含式I和/或II化合物的组合物以及所述化合物和组合物用于抑制微管聚合，诱导溶酶体破坏和/或治疗癌症的用途， 包括血液癌症如白血病。

公开(公告)号：WO2014029016A1

公开(公告)日：2014-02-27

申请号：PCT/CA2013/000742

申请日：2013-08-23

Applicant: UNIVERSITY HEALTH NETWORK ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： SCHIMMER, Aaron David ,  ZHENG, Wei ,  McKEW, John ,  CHEN, Catherine ,  SOUTHALL, Noel

IPC: A61K31/65 ,  A61K31/404 ,  A61K31/42 ,  A61K31/455 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/502 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/553 ,  A61P35/00

CPC classification number: A61K31/404 ,  A61K31/42 ,  A61K31/455 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/502 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/553 ,  A61K31/65 ,  A61K45/06 ,  A61K2300/00

Abstract: Methods, kits and compositions for treating a cancer, the method comprising administering to a subject in need thereof a glycylcycline, for example tigecycline, and a TKI, wherein the glycylcycline and the TKI are provided in a synergistic ratio.

Abstract translation: 用于治疗癌症的方法，试剂盒和组合物，所述方法包括向有需要的受试者施用甘氨酰环霉素，例如替加环素和TKI，其中甘氨酰环霉素和TKI以协同比提供。

公开(公告)号：WO2011041914A1

公开(公告)日：2011-04-14

申请号：PCT/CA2010/001627

申请日：2010-10-08

Applicant: UNIVERSITY HEALTH NETWORK (UHN) ,  SCHIMMER, Aaron David ,  HU, Jiayi ,  SPAGNUOLO, Paul, Anthony

Inventor： SCHIMMER, Aaron David ,  HU, Jiayi ,  SPAGNUOLO, Paul, Anthony

IPC: A61K31/4184 ,  A61K31/475 ,  A61P35/00 ,  A61P35/02

CPC classification number: A61K31/4184 ,  A61K31/475 ,  A61K45/06 ,  A61K2300/00

Abstract: Provided are methods for treating a hematological malignancy comprising administering an effective amount of flubendazole alone or in combination with a vinca alkaloid. Also provided are compositions and kits comprising an effective amount of flubendazole and/or a vinca alkaloid for use in the methods of the disclosure.

Abstract translation: 提供了用于治疗血液恶性肿瘤的方法，包括单独或与长春花生物碱组合施用有效量的氟苯达唑。 还提供了组合物和试剂盒，其包含用于本公开的方法的有效量的氟苯达唑和/或长春花生物碱。

公开(公告)号：EP4100513A1

公开(公告)日：2022-12-14

申请号：EP21750194.9

申请日：2021-02-08

Applicant: University Health Network

Inventor： ZHANG, Li ,  LEE, Jongbok ,  SCHIMMER, Aaron David

IPC: C12N5/0783 ,  A61K31/437 ,  A61K35/17 ,  A61P35/00 ,  A61P35/02 ,  C07D471/04