公开(公告)号：WO2016023134A1

公开(公告)日：2016-02-18

申请号：PCT/CA2015/050780

申请日：2015-08-17

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： ZHANG, Li ,  LEE, Jong Bok ,  CHEN, Branson

IPC: A61K35/17 ,  A61P35/02

CPC classification number: A61K39/0011 ,  A61K31/7068 ,  A61K35/17 ,  A61K2039/5158

Abstract: Methods for the treatment of cancer using double negative (DN) T cells are described. The DNTs may be used for the treatment of chemotherapy- resistant cancers such as recurring or relapsing acute myeloid leukemia (AML). The use of allogenic DNTs, such as those derived from healthy donors, that do not exhibit toxicity towards normal host tissues and the complications associated with graft-versus-host-disease, is also described.

Abstract translation: 描述了使用双重阴性（DN）T细胞治疗癌症的方法。 DNT可用于治疗化疗耐药性癌症，例如复发性或复发性急性骨髓性白血病（AML）。 还描述了使用不对正常宿主组织显示毒性的同种异体DNT（例如来自健康供体的那些），以及与移植物抗宿主病相关的并发症。

公开(公告)号：EP3180011A1

公开(公告)日：2017-06-21

申请号：EP15832624.9

申请日：2015-08-17

Applicant: University Health Network

Inventor： ZHANG, Li ,  LEE, Jong Bok ,  CHEN, Branson

IPC: A61K35/17 ,  A61P35/02

CPC classification number: A61K39/0011 ,  A61K31/7068 ,  A61K35/17 ,  A61K2039/5158

Abstract: Methods for the treatment of cancer using double negative (DN) T cells are described. The DNTs may be used for the treatment of chemotherapy-resistant cancers such as recurring or relapsing acute myeloid leukemia (AML). The use of allogenic DNTs, such as those derived from healthy donors, that do not exhibit toxicity towards normal host tissues and the complications associated with graft-versus-host-disease, is also described.

Abstract translation: 描述了使用双阴性（DN）T细胞治疗癌症的方法。 DNT可用于治疗化疗耐药性癌症，如复发或复发性急性髓性白血病（AML）。 也描述了对正常宿主组织没有表现出毒性以及与移植物抗宿主病有关的并发症的同种异体DNT，例如源自健康供体的DNT。