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公开(公告)号：WO2021108926A1
公开(公告)日：2021-06-10
申请号：PCT/CA2020/051682
申请日：2020-12-07
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： ZHANG, Li , LEE, Jong Bok , VASIC, Daniel , KHATRI, Ismat , LY, Dalam , LEUNG, Yuki Sze Long
IPC: C12N5/10 , A61K35/17 , A61P35/00 , C07K14/705 , C07K19/00 , C12N15/62 , C12N15/85 , C12N5/0783
Abstract: The disclosure relates to the development and use of CD4- CD8- double negative T (DNT) cells genetically modified to bind to one or more target antigens to enhance DNT cell anti-cancer activity such as with a chimeric antigen receptor (CAR). Genetically modified DNT cells can be generated ex vivo and expanded from allogeneic healthy donor cells and used as off-the-shelf therapy to overcome allogeneic graft-versus-host disease (GvHD) and/or host-versus-graft rejection in the treatment of cancer.
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公开(公告)号：WO2021155479A1
公开(公告)日：2021-08-12
申请号：PCT/CA2021/050138
申请日：2021-02-08
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： ZHANG, Li , LEE, Jong Bok , SCHIMMER, Aaron David
IPC: C12N5/0783 , A61K31/437 , A61K35/17 , A61P35/00 , A61P35/02 , C07D471/04
Abstract: Methods of treating T cells with Venetoclax to increase T cell-mediated cytotoxicity and/or T cell mediated anti-tumor activity are described. Also described are populations of enhanced T cells as well as associated methods and uses for the treatment of cancer.
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Patent Agency Ranking
公开(公告)号：WO2020124248A1
公开(公告)日：2020-06-25
申请号：PCT/CA2019/051866
申请日：2019-12-19
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： ZHANG, Li , LEE, Jong Bok , KANG, Hyeonjeong
IPC: C12N5/0783 , A01N1/02 , A61K35/17 , A61P35/00
Abstract: Described are methods for the production and use of cryopreservable double negative T cells (DNTs) for the treatment of cancer as an off-the-shelf cellular therapy. A sample population of DNTs is expanded using DNTs from one or more donors. The expanded population of DNTs from different donors does not exhibit alloreactivity against allogenic cells in the expanded population. The expanded populations of DNTs can be long-term stored as cryopreserved products.
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公开(公告)号：WO2016023134A1
公开(公告)日：2016-02-18
申请号：PCT/CA2015/050780
申请日：2015-08-17
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： ZHANG, Li , LEE, Jong Bok , CHEN, Branson
CPC classification number: A61K39/0011 , A61K31/7068 , A61K35/17 , A61K2039/5158
Abstract: Methods for the treatment of cancer using double negative (DN) T cells are described. The DNTs may be used for the treatment of chemotherapy- resistant cancers such as recurring or relapsing acute myeloid leukemia (AML). The use of allogenic DNTs, such as those derived from healthy donors, that do not exhibit toxicity towards normal host tissues and the complications associated with graft-versus-host-disease, is also described.
Abstract translation: 描述了使用双重阴性（DN）T细胞治疗癌症的方法。 DNT可用于治疗化疗耐药性癌症，例如复发性或复发性急性骨髓性白血病（AML）。 还描述了使用不对正常宿主组织显示毒性的同种异体DNT（例如来自健康供体的那些），以及与移植物抗宿主病相关的并发症。
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公开(公告)号：EP3898950A1
公开(公告)日：2021-10-27
申请号：EP19898965.9
申请日：2019-12-19
Applicant: University Health Network
Inventor： ZHANG, Li , LEE, Jong Bok , KANG, Hyeonjeong
IPC: C12N5/0783 , A01N1/02 , A61K35/17 , A61P35/00
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公开(公告)号：EP3180011A1
公开(公告)日：2017-06-21
申请号：EP15832624.9
申请日：2015-08-17
Applicant: University Health Network
Inventor： ZHANG, Li , LEE, Jong Bok , CHEN, Branson
CPC classification number: A61K39/0011 , A61K31/7068 , A61K35/17 , A61K2039/5158
Abstract: Methods for the treatment of cancer using double negative (DN) T cells are described. The DNTs may be used for the treatment of chemotherapy-resistant cancers such as recurring or relapsing acute myeloid leukemia (AML). The use of allogenic DNTs, such as those derived from healthy donors, that do not exhibit toxicity towards normal host tissues and the complications associated with graft-versus-host-disease, is also described.
Abstract translation: 描述了使用双阴性（DN）T细胞治疗癌症的方法。 DNT可用于治疗化疗耐药性癌症，如复发或复发性急性髓性白血病（AML）。 也描述了对正常宿主组织没有表现出毒性以及与移植物抗宿主病有关的并发症的同种异体DNT，例如源自健康供体的DNT。
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公开(公告)号：EP4069831A1
公开(公告)日：2022-10-12
申请号：EP20896982.4
申请日：2020-12-07
Applicant: University Health Network
Inventor： ZHANG, Li , LEE, Jong Bok , VASIC, Daniel , KHATRI, Ismat , LY, Dalam , LEUNG, Yuki Sze Long
IPC: C12N5/10 , A61K35/17 , A61P35/00 , C07K14/705 , C07K19/00 , C12N15/62 , C12N15/85 , C12N5/0783
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