公开(公告)号：WO2018032088A2

公开(公告)日：2018-02-22

申请号：PCT/CA2017/000192

申请日：2017-08-17

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： NGUYEN, Thuy-Linh ,  OHASHI, Pamela S. ,  CROME, Sarah

IPC: A61P35/00

Abstract: There is described herein methods for improving tumor infiltrating lymphocyte (TIL) therapy by limiting the effect of innate lymphoid cells (ILCs) thereon. For example, in an aspect, there is provided a method of treating cancer in a patient in need thereof, comprising inhibiting the suppressive effect of CD56 + CD3 - innate lymphoid cells (ILCs) on tumor infiltrating lymphocyte (TIL) propagation or expansion.

Abstract translation: 本文描述了通过限制其上的先天性淋巴细胞（ILC）的作用来改善肿瘤浸润性淋巴细胞（TIL）治疗的方法。 例如，在一个方面，提供了在有需要的患者中治疗癌症的方法，包括抑制CD56 + CD3 - 天然淋巴样细胞的抑制作用（ ILCs）对肿瘤浸润淋巴细胞（TIL）增殖或扩增的影响。

公开(公告)号：WO2018032088A3

公开(公告)日：2018-02-22

申请号：PCT/CA2017/000192

申请日：2017-08-17

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： NGUYEN, Thuy-Linh ,  OHASHI, Pamela S. ,  CROME, Sarah

IPC: A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  G01N33/48

Abstract: There is described herein methods for improving tumor infiltrating lymphocyte (TIL) therapy by limiting the effect of innate lymphoid cells (ILCs) thereon. For example, in an aspect, there is provided a method of treating cancer in a patient in need thereof, comprising inhibiting the suppressive effect of CD56 + CD3 - innate lymphoid cells (ILCs) on tumor infiltrating lymphocyte (TIL) propagation or expansion.

公开(公告)号：EP3500298A2

公开(公告)日：2019-06-26

申请号：EP17840653.4

申请日：2017-08-17

Applicant: University Health Network

Inventor： NGUYEN, Thuy-Linh ,  OHASHI, Pamela S. ,  CROME, Sarah

IPC: A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  G01N33/48

公开(公告)号：EP4539862A1

公开(公告)日：2025-04-23

申请号：EP23825718.2

申请日：2023-06-20

Applicant: University Health Network

Inventor： CROME, Sarah ,  REID, Kyle ,  MATHEWS, Jessica ,  MURPHY, Julia ,  COLPITTS, Sarah

IPC: A61K35/17 ,  A61P37/02 ,  C12N5/078 ,  C12Q1/6881 ,  G01N33/48