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Patent Agency Ranking
公开(公告)号：WO2018032088A2
公开(公告)日：2018-02-22
申请号：PCT/CA2017/000192
申请日：2017-08-17
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： NGUYEN, Thuy-Linh , OHASHI, Pamela S. , CROME, Sarah
IPC: A61P35/00
Abstract: There is described herein methods for improving tumor infiltrating lymphocyte (TIL) therapy by limiting the effect of innate lymphoid cells (ILCs) thereon. For example, in an aspect, there is provided a method of treating cancer in a patient in need thereof, comprising inhibiting the suppressive effect of CD56 + CD3 - innate lymphoid cells (ILCs) on tumor infiltrating lymphocyte (TIL) propagation or expansion.
Abstract translation: 本文描述了通过限制其上的先天性淋巴细胞（ILC）的作用来改善肿瘤浸润性淋巴细胞（TIL）治疗的方法。 例如，在一个方面，提供了在有需要的患者中治疗癌症的方法，包括抑制CD56 + CD3 - 天然淋巴样细胞的抑制作用（ ILCs）对肿瘤浸润淋巴细胞（TIL）增殖或扩增的影响。
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公开(公告)号：WO2009036568A1
公开(公告)日：2009-03-26
申请号：PCT/CA2008/001653
申请日：2008-09-19
Applicant: UNIVERSITY HEALTH NETWORK , MAK, Tak W. , OHASHI, Pamela S. , CALZASCIA, Thomas , PELLEGRINI, Marc
Inventor： MAK, Tak W. , OHASHI, Pamela S. , CALZASCIA, Thomas , PELLEGRINI, Marc
CPC classification number: A61K39/0011 , A01K2267/0331 , A61K38/2046 , A61K2039/55527 , C12N2760/10011 , A61K2300/00
Abstract: Methods for treating a tumor in a mammal, the method comprising administering to the mammal interleukin-7 (IL-7) and an antigen of the tumor in an amount sufficient to induce an immunogenic response thereto, pharmaceutical compositions and kits comprising IL-7 and antigen of the tumor. The invention also features methods for treating a viral infection in a mammal, the method comprising administering to the mammal IL-7 and a viral antigen in an amount sufficient to induce an immunogenic response thereto, pharmaceutical compositions and kits comprising IL-7 and a viral antigen.
Abstract translation: 用于治疗哺乳动物肿瘤的方法，所述方法包括给予哺乳动物白细胞介素-7（IL-7）和肿瘤抗原足以诱导免疫原性的应答，药物组合物和试剂盒包含IL-7和 肿瘤抗原。 本发明还涉及用于治疗哺乳动物的病毒感染的方法，所述方法包括以足以诱导免疫原性应答的量向哺乳动物施用IL-7和病毒抗原，药物组合物和包含IL-7和病毒 抗原。
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公开(公告)号：WO2018132889A1
公开(公告)日：2018-07-26
申请号：PCT/CA2017/000270
申请日：2017-12-19
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： St. PAUL, Michael , OHASHI, Pamela S.
Abstract: There is described herein a method for inducing Tc22 lineage T cells from a population of CD8+ T cells, the method comprising: a) providing a population of CD8+ T cells; b) activating the population of CD8+ T cells; and c) culturing or contacting the population of CD8+ T cells with IL-6.
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公开(公告)号：WO2018032088A3
公开(公告)日：2018-02-22
申请号：PCT/CA2017/000192
申请日：2017-08-17
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： NGUYEN, Thuy-Linh , OHASHI, Pamela S. , CROME, Sarah
IPC: A61K39/395 , A61P35/00 , C07K16/28 , C07K16/30 , G01N33/48
Abstract: There is described herein methods for improving tumor infiltrating lymphocyte (TIL) therapy by limiting the effect of innate lymphoid cells (ILCs) thereon. For example, in an aspect, there is provided a method of treating cancer in a patient in need thereof, comprising inhibiting the suppressive effect of CD56 + CD3 - innate lymphoid cells (ILCs) on tumor infiltrating lymphocyte (TIL) propagation or expansion.
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公开(公告)号：EP3500298A2
公开(公告)日：2019-06-26
申请号：EP17840653.4
申请日：2017-08-17
Applicant: University Health Network
Inventor： NGUYEN, Thuy-Linh , OHASHI, Pamela S. , CROME, Sarah
IPC: A61K39/395 , A61P35/00 , C07K16/28 , C07K16/30 , G01N33/48
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