公开(公告)号：WO2015192215A1

公开(公告)日：2015-12-23

申请号：PCT/CA2015/000397

申请日：2015-06-18

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： CHEN, Juan ,  ZHENG, Gang ,  CUI, Liyang

IPC: A61K9/133 ,  A61K41/00 ,  A61K47/24 ,  A61K47/42 ,  A61K49/00 ,  A61K9/51 ,  A61P35/00

CPC classification number: B82Y5/00 ,  A61K9/1075 ,  A61K9/5169 ,  A61K31/337 ,  A61K31/404 ,  A61K41/0071 ,  A61K41/0076 ,  A61K47/42 ,  A61K47/544 ,  A61K47/6907 ,  A61K49/0036 ,  Y10S977/773 ,  Y10S977/801 ,  Y10S977/906 ,  Y10S977/915

Abstract: There is provided herein a nanovesicle comprising a monolayer of phospholipid, porphyrin-phospholipid conjugate and a peptide encapsulating a hydrophobic core, wherein the peptide comprises an amino acid sequence capable of forming at least one amphipathic α-helix; the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipid; the molar % of porphyrin-phospholipid conjugate to phospholipid is 35% or less; the nanovesicle is 35nm in diameter or less.

Abstract translation: 本文提供了包含磷脂单层，卟啉 - 磷脂缀合物和封装疏水核心的肽的纳米囊，其中肽包含能够形成至少一个两亲性α-螺旋的氨基酸序列; 卟啉 - 磷脂缀合物包含一个磷脂的一个卟啉，卟啉衍生物或卟啉类似物共价连接到脂质侧链，优选在sn-1或sn-2位; 卟啉 - 磷脂缀合物对磷脂的摩尔％为35％以下; 纳米囊直径为35nm或更小。

公开(公告)号：EP3157509A1

公开(公告)日：2017-04-26

申请号：EP15809455.7

申请日：2015-06-18

Applicant: University Health Network

Inventor： CHEN, Juan ,  ZHENG, Gang ,  CUI, Liyang

IPC: A61K9/133 ,  A61K41/00 ,  A61K47/24 ,  A61K47/42 ,  A61K49/00 ,  A61K9/51 ,  A61P35/00

CPC classification number: B82Y5/00 ,  A61K9/1075 ,  A61K9/5169 ,  A61K31/337 ,  A61K31/404 ,  A61K41/0071 ,  A61K41/0076 ,  A61K47/42 ,  A61K47/544 ,  A61K47/6907 ,  A61K49/0036 ,  Y10S977/773 ,  Y10S977/801 ,  Y10S977/906 ,  Y10S977/915

Abstract: There is provided herein a nanovesicle comprising a monolayer of phospholipid, porphyrin-phospholipid conjugate and a peptide encapsulating a hydrophobic core, wherein the peptide comprises an amino acid sequence capable of forming at least one amphipathic α-helix; the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipid; the molar % of porphyrin-phospholipid conjugate to phospholipid is 35% or less; the nanovesicle is 35 nm in diameter or less.

Abstract translation: 本文提供了包含单层磷脂，卟啉 - 磷脂缀合物和包封疏水核心的肽的纳米囊泡，其中所述肽包含能够形成至少一个两亲性α-螺旋的氨基酸序列; 卟啉 - 磷脂缀合物包含一种卟啉，卟啉衍生物或卟啉类似物，其共价连接至一个磷脂的脂质侧链，优选在sn-1或sn-2位; 卟啉 - 磷脂结合物与磷脂的摩尔百分比为35％或更少; 纳米囊泡的直径为35nm或更小。