中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

25 records (took 0.027 seconds)

    "> HIGH-DENSITY LIPOPROTEIN-LIKE PEPTIDE-PHOSPHOLIPID SCAFFOLD (
    2.
    发明申请
    HIGH-DENSITY LIPOPROTEIN-LIKE PEPTIDE-PHOSPHOLIPID SCAFFOLD ("HPPS") NANOPARTICLES 审中-公开
    高密度脂蛋白胆固醇 - 磷脂酰胆碱（“HPPS”）纳米颗粒

    公开(公告)号：WO2009073984A1

    公开(公告)日：2009-06-18

    申请号：PCT/CA2008/002203

    申请日：2008-12-12

    Applicant: UNIVERSITY HEALTH NETWORK ,  ZHENG, Gang ,  ZHANG, Zhihong ,  CORBIN, Ian ,  CHEN, Juan

    Inventor： ZHENG, Gang ,  ZHANG, Zhihong ,  CORBIN, Ian ,  CHEN, Juan

    IPC: C07K17/02 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  A61K51/04 ,  A61P35/00 ,  C12N15/10 ,  C12N15/11 ,  G01N33/566 ,  G01N33/574 ,  C07K14/485 ,  C07K14/71 ,  C12N15/87

    CPC classification number: A61K49/0082 ,  A61K47/6917 ,  A61K47/6919 ,  A61K49/0002 ,  A61K49/0032 ,  A61K49/0056 ,  B82Y5/00 ,  G01N33/54346 ,  G01N33/587 ,  G01N2800/00

    Abstract: The present invention provides a non-naturally occurring High-Density Lipoprotein-like peptide-phospholipid scaffold ("HPPS") nanoparticle. More particularly, the invention provides a non-naturally occurring peptide-lipid nanoscaffold comprising: (a) at least one phospholipid; (b) at least one unsaturated lipid, preferably an unsaturated sterol ester, further preferably an unsaturated cholesterol ester, further preferably cholsteryl oleate; and (c) at least one peptide, the peptide comprising an amino acid sequence capable of forming at least one amphipathic a- helix; wherein the components a), b) and c) associate to form the peptide-phospholipid nanoscaffold. In embodiments of the present invention, a cell surface receptor ligand is incorporated into the HPPS. In one embodiment, the cell surface receptor ligand is covalently bonded to the peptide scaffold of the HPPS nanoparticles. In other embodiments, a cell surface receptor ligand is coupled to a lipid anchor and is displayed on the surface of the HPPS nanoparticles by incorporation of the lipid anchor into the phospholipids monolayer of the HPPS nanoparticle. The present invention also provides pharmaceutical formulations comprising HPPS nanoparticles and methods of making the HPPS nanoparticles.

    Abstract translation: 本发明提供非天然存在的高密度脂蛋白样肽 - 磷脂支架（“HPPS”）纳米颗粒。 更具体地，本发明提供非天然存在的肽 - 脂质纳米支架，其包含：（a）至少一种磷脂; （b）至少一种不饱和脂质，优选不饱和甾醇酯，更优选不饱和胆固醇酯，更优选油酸胆甾醇酯; 和（c）至少一种肽，所述肽包含能够形成至少一种两亲α-螺旋的氨基酸序列; 其中组分a），b）和c）缔合形成肽 - 磷脂纳米支架。 在本发明的实施方案中，将细胞表面受体配体掺入HPPS中。 在一个实施方案中，细胞表面受体配体共价键合到HPPS纳米颗粒的肽支架上。 在其它实施方案中，将细胞表面受体配体偶联到脂质锚定物上，并通过将脂质锚点掺入HPPS纳米颗粒的磷脂单层中而显示在HPPS纳米颗粒的表面上。 本发明还提供了包含HPPS纳米颗粒的药物制剂和制备HPPS纳米颗粒的方法。

    NANOVESICLES COMPRISING PORPHYRIN-LIPID CONJUGATES EXHIBITING ORDERED ASSEMBLY AND BATHOCHROMIC SHIFTS
    5.
    发明申请
    NANOVESICLES COMPRISING PORPHYRIN-LIPID CONJUGATES EXHIBITING ORDERED ASSEMBLY AND BATHOCHROMIC SHIFTS 审中-公开
    包含卟啉脂质偶联物的纳米材料显示有序组装和BATHCHROMIC SHICTS

    公开(公告)号：WO2017156616A1

    公开(公告)日：2017-09-21

    申请号：PCT/CA2017/000052

    申请日：2017-03-10

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： ZHENG, Gang ,  NG, Kenneth ,  CHEN, Juan ,  TAKEDA, Misa ,  HARMATYS, Kara

    IPC: A61K47/69 ,  A61K41/00 ,  A61K49/00 ,  A61K9/127 ,  A61K9/51 ,  A61P35/00 ,  C07K14/775 ,  C07K17/02

    Abstract: The application relates to liposomal nanovesicles comprising porphyrin-lipid conjugates within the liposomal lipid bilayer. Said porphyrin-lipid conjugate comprise porphyrins that are modified with a -CH(R 1 )-O-R 2 group and that chelate a metal ion. Such modifications of the porphyrin allow for ordered assembly in the lipid bilayer of the nanovesicles while resulting in a bathochromic shift in the wavelength of light absorbed by the porphyrin chromophore. These nanovesicles can be used for photothermal therapy, photodynamic therapy, photoacoustic imaging and fluorescence imaging. The application also teaches methods for preparing the porphyrin-lipid conjugates and the nanovesicles.

    Abstract translation: 本申请涉及在脂质体脂质双层内包含卟啉 - 脂质缀合物的脂质体纳米囊泡。 所述卟啉 - 脂质缀合物包含用-CH（R 1）-O-R 2基团修饰并螯合金属离子的卟啉。 卟啉的这种修饰允许在纳米囊泡的脂双层中的有序组装，同时导致由卟啉发色团吸收的光的波长发生红移。 这些纳米囊泡可用于光热疗法，光动力疗法，光声成像和荧光成像。 该申请还教导了用于制备卟啉 - 脂质缀合物和纳米囊泡的方法。

    PORPHYRIN NANOVESICLES
    9.
    发明申请
    PORPHYRIN NANOVESICLES 审中-公开

    公开(公告)号：WO2011044671A1

    公开(公告)日：2011-04-21

    申请号：PCT/CA2010/001573

    申请日：2010-10-05

    Applicant: UNIVERSITY HEALTH NETWORK ,  ZHENG, Gang ,  LOVELL, Jonathan F.

    Inventor： ZHENG, Gang ,  LOVELL, Jonathan F.

    IPC: A61K47/24 ,  A61K41/00 ,  A61K49/00 ,  A61K51/04 ,  A61K9/127

    CPC classification number: A61K41/0071 ,  A61K47/544 ,  A61K49/0036 ,  A61K49/0084 ,  Y10T428/2991

    Abstract: The application relates to a nanovesicle comprising a bilayer of at least 15 mol% porphyrin-phospholipid conjugate, wherein the conjugate comprises a porphyrin, porphyrin derivative or porphyrin analog covalently attached to the phospholipid side chain. The nanovesicle can be used for photothermal therapy, photoacoustic imaging, and fluorescence imaging. The application also discloses a method of preparing the said nanovesicle.

    Abstract translation: 本申请涉及包含至少15mol％卟啉 - 磷脂缀合物的双层的纳米囊，其中所述缀合物包含共价连接到磷脂侧链的卟啉，卟啉衍生物或卟啉类似物。 纳米囊可用于光热治疗，光声成像和荧光成像。 本申请还公开了一种制备所述纳米囊的方法。

Patent Agency Ranking