公开(公告)号：US10441668B2

公开(公告)日：2019-10-15

申请号：US15533799

申请日：2015-12-08

Applicant: University Health Network

Inventor： Arash Zarrine-Afsar ,  David Anthony Jaffray

IPC: A61K49/10 ,  A61K49/00 ,  A61K49/04 ,  G01N27/00 ,  G01N33/483 ,  G01N33/58 ,  H01J49/00 ,  H01J49/10

Abstract: Various embodiments are described herein for a system and a method for identifying a region of interest in tissue using mass spectrometry. An agent administration component can be provided to administer an exogenous agent to the tissue. A sampling unit can also be provided to acquire a sample from the tissue. The sample can then be provided to a high sensitivity analysis platform, such as a mass analyzer, to analyze the sample and determine a distribution of the exogenous agent or a by-product of the exogenous agent within the tissue based on the analysis. The analysis platform can then identify the region of interest based on the distribution of the exogenous agent or the distribution of the by-product.

公开(公告)号：US20170368205A1

公开(公告)日：2017-12-28

申请号：US15533799

申请日：2015-12-08

Applicant: University Health Network

Inventor： Arash Zarrine-Afsar ,  David Anthony Jaffray

IPC: A61K49/10 ,  G01N33/58 ,  H01J49/10 ,  G01N27/00 ,  G01N33/483 ,  H01J49/00

CPC classification number: A61K49/106 ,  A61K49/00 ,  A61K49/0438 ,  G01N27/00 ,  G01N33/4833 ,  G01N33/58 ,  G01N2458/15 ,  G01N2560/00 ,  H01J49/0004 ,  H01J49/105

Abstract: Various embodiments are described herein for a system and a method for identifying a region of interest in tissue using mass spectrometry. An agent administration component can be provided to administer an exogenous agent to the tissue. A sampling unit can also be provided to acquire a sample from the tissue. The sample can then be provided to a high sensitivity analysis platform, such as a mass analyzer, to analyze the sample and determine a distribution of the exogenous agent or a by-product of the exogenous agent within the tissue based on the analysis. The analysis platform can then identify the region of interest based on the distribution of the exogenous agent or the distribution of the by-product.

公开(公告)号：US20220023666A1

公开(公告)日：2022-01-27

申请号：US17311968

申请日：2019-12-10

Applicant: University Health Network

Inventor： Young-Bin Cho ,  Mohammad Khairul Islam ,  David Anthony Jaffray ,  Bernhard Dieter Norrlinger ,  Makan Farrokhkish ,  Robert K. Heaton

IPC: A61N5/10 ,  G06N3/04 ,  G16H20/40 ,  G01T1/02

Abstract: Various embodiments are described herein of radiation systems and methods for monitoring radiation dose are provided monitoring an amount of radiation in a radiation beam generated by a radiation source for a radiation treatment session, where a radiation sensor is used to provide an actual radiation measurement and an Artificial Neural Network (ANN) engine is used to generate a predicted radiation measurement based on a plurality of feature values for features including radiation field segments from the radiation treatment plan data for the radiation treatment session. The difference between the actual radiation measurement and the predicted radiation measurement is used to determine whether the radiation system is operating in a predetermined safe operation range.

公开(公告)号：US10596393B2

公开(公告)日：2020-03-24

申请号：US14417631

申请日：2013-07-29

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Teodor Marius Stanescu ,  David Anthony Jaffray

IPC: A61N5/10 ,  A61B5/055 ,  A61B6/00 ,  G01R33/48 ,  G01R33/567 ,  A61B5/00

Abstract: A Radio-Therapy (RT) system includes an integrated radiation source and a Magnetic Resonance Imaging (MRI) system that implements a method for providing a variable imaging Field Of View (FOV). The FOV can be tailored for various RT-specific applications such as, but not limited to, patient setup verification and real-time tumor tracking, for example, as well as for various imaging volumes of interest.

公开(公告)号：US20150217136A1

公开(公告)日：2015-08-06

申请号：US14417631

申请日：2013-07-29

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Teodor Marius Stanescu ,  David Anthony Jaffray

IPC: A61N5/10 ,  A61B5/055 ,  G01R33/567

CPC classification number: A61N5/1049 ,  A61B5/0035 ,  A61B5/055 ,  A61B6/4417 ,  A61N2005/1055 ,  A61N2005/1091 ,  G01R33/4808 ,  G01R33/567

Abstract: Various embodiments are described herein for a Radio-Therapy (RT) system and an associated method and in particular to an integrated radiation source with an MRI system featuring a variable imaging Field Of View (FOV). The FOV can be tailored for various RT-specific applications such as, but not limited to, patient setup verification and real-time tumor tracking, for example, as well as for various imaging volumes of interest.

Abstract translation: 本文描述了用于放射治疗（RT）系统和相关方法的各种实施例，特别涉及具有可变成像视场（FOV）的MRI系统的综合辐射源。 FOV可以针对各种RT特异性应用而定制，例如但不限于患者设置验证和实时肿瘤跟踪，例如以及感兴趣的各种成像体积。

公开(公告)号：US09053890B2

公开(公告)日：2015-06-09

申请号：US13958120

申请日：2013-08-02

Applicant: University Health Network

Inventor： Yonghai Sun ,  Tze-wei Yeow ,  David Anthony Jaffray

IPC: H01J1/304 ,  H01J1/30 ,  H01J9/02 ,  H01J35/06

CPC classification number: H01J9/025 ,  H01J1/304 ,  H01J35/065 ,  H01J2201/3043 ,  H01J2201/30449 ,  H01J2201/30469 ,  H01J2201/30496 ,  H01J2235/068 ,  Y10S977/81 ,  Y10S977/811

Abstract: Various embodiments are described herein for nanostructure field emission cathode structures and methods of making these structures. These structures generally comprise an electrode field emitter comprising a resistive layer having a first surface, a connection pad having a first surface disposed adjacent to the first surface of the resistive layer, and a nanostructure element for emitting electrons in use, the nanostructure element being disposed adjacent to a second surface of the connection pad that is opposite the first surface of the connection pad. Some embodiments also include a coaxial gate electrode that is disposed about the nanostructure element.

Abstract translation: 本文描述了用于纳米结构场发射阴极结构和制造这些结构的方法的各种实施例。 这些结构通常包括电极场发射器，其包括具有第一表面的电阻层，具有邻近电阻层的第一表面设置的第一表面的连接焊盘和用于在使用中发射电子的纳米结构元件，所述纳米结构元件被布置 邻近连接垫的与连接垫的第一表面相对的第二表面。 一些实施例还包括围绕纳米结构元件设置的同轴栅电极。