公开(公告)号：WO2020028324A1

公开(公告)日：2020-02-06

申请号：PCT/US2019/044075

申请日：2019-07-30

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  UNIVERSITY HEALTH NETWORK

Inventor： POMPER, Martin G. ,  MEASE, Ronnie C. ,  CHEN, Ying ,  RAY, Sangeeta ,  CHEN, Juan ,  OVERCHUCK, Marta ,  HARMATYS, Kara ,  ZHENG, Gang

IPC: A61K41/00 ,  A61K47/54 ,  A61K47/65 ,  A61P35/00 ,  A61P13/08

Abstract: Theranostic probes comprising a porphyrin-based photosensitizer, a D-peptide linker, and a urea-based PSMA-targeting ligand and methods of their use for treating and/or imaging PMSA-expressing tumors are disclosed.

公开(公告)号：WO2017156616A1

公开(公告)日：2017-09-21

申请号：PCT/CA2017/000052

申请日：2017-03-10

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： ZHENG, Gang ,  NG, Kenneth ,  CHEN, Juan ,  TAKEDA, Misa ,  HARMATYS, Kara

IPC: A61K47/69 ,  A61K41/00 ,  A61K49/00 ,  A61K9/127 ,  A61K9/51 ,  A61P35/00 ,  C07K14/775 ,  C07K17/02

Abstract: The application relates to liposomal nanovesicles comprising porphyrin-lipid conjugates within the liposomal lipid bilayer. Said porphyrin-lipid conjugate comprise porphyrins that are modified with a -CH(R 1 )-O-R 2 group and that chelate a metal ion. Such modifications of the porphyrin allow for ordered assembly in the lipid bilayer of the nanovesicles while resulting in a bathochromic shift in the wavelength of light absorbed by the porphyrin chromophore. These nanovesicles can be used for photothermal therapy, photodynamic therapy, photoacoustic imaging and fluorescence imaging. The application also teaches methods for preparing the porphyrin-lipid conjugates and the nanovesicles.

Abstract translation: 本申请涉及在脂质体脂质双层内包含卟啉 - 脂质缀合物的脂质体纳米囊泡。 所述卟啉 - 脂质缀合物包含用-CH（R 1）-O-R 2基团修饰并螯合金属离子的卟啉。 卟啉的这种修饰允许在纳米囊泡的脂双层中的有序组装，同时导致由卟啉发色团吸收的光的波长发生红移。 这些纳米囊泡可用于光热疗法，光动力疗法，光声成像和荧光成像。 该申请还教导了用于制备卟啉 - 脂质缀合物和纳米囊泡的方法。