公开(公告)号：WO2020124248A1

公开(公告)日：2020-06-25

申请号：PCT/CA2019/051866

申请日：2019-12-19

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： ZHANG, Li ,  LEE, Jong Bok ,  KANG, Hyeonjeong

IPC: C12N5/0783 ,  A01N1/02 ,  A61K35/17 ,  A61P35/00

Abstract: Described are methods for the production and use of cryopreservable double negative T cells (DNTs) for the treatment of cancer as an off-the-shelf cellular therapy. A sample population of DNTs is expanded using DNTs from one or more donors. The expanded population of DNTs from different donors does not exhibit alloreactivity against allogenic cells in the expanded population. The expanded populations of DNTs can be long-term stored as cryopreserved products.

公开(公告)号：EP3898950A1

公开(公告)日：2021-10-27

申请号：EP19898965.9

申请日：2019-12-19

Applicant: University Health Network

Inventor： ZHANG, Li ,  LEE, Jong Bok ,  KANG, Hyeonjeong

IPC: C12N5/0783 ,  A01N1/02 ,  A61K35/17 ,  A61P35/00