-
公开(公告)号：WO2016119045A1
公开(公告)日：2016-08-04
申请号：PCT/CA2016/000023
申请日：2016-01-26
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： KOTRA, Lakshmi P. , PAIGE, Christopher John , BELLO , Angelica Mara , SHERMAN, Igor
IPC: A61K47/42 , A61K31/337 , A61K9/19 , A61P35/00 , C07D305/14 , C07K14/47
CPC classification number: A61K31/337 , A61K9/0019 , A61K9/19 , A61K47/42 , C07D305/14 , C07K14/4715
Abstract: Compositions which comprise a hydrophobic taxane such as paclitaxel are produced by non-covalent complexing between the taxane and alpha-fetoprotein c at a ratio of about 4 moles of taxane per mole of AFP. The complexes are water soluble and suitable for injection. Uses of the compositions for treating a subject presenting with an AFP receptor positive and taxane responsive disease cell are also disclosed.
Abstract translation: 包含疏水紫杉烷如紫杉醇的组合物通过紫杉烷和甲胎蛋白c之间的非共价络合产生，每摩尔AFP的比例为约4摩尔紫杉烷。 络合物是水溶性的并且适于注射。 还公开了用于治疗呈现AFP受体阳性和紫杉烷应答疾病细胞的受试者的组合物的用途。
-
2.发明申请
公开(公告)号：WO2017027967A1
公开(公告)日：2017-02-23
申请号：PCT/CA2016/050958
申请日：2016-08-15
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： KOTRA, Lakshmi P. , WASILEWSKI, Ewa
IPC: C07D307/54 , A61K31/341 , A61K31/4178 , A61K31/4192 , A61K31/495 , A61K31/5377 , A61P21/00 , A61P25/28 , C07D295/15 , C07D295/185 , C07D403/12 , C07K5/078
CPC classification number: A61K31/341 , A61K31/4178 , A61K31/4192 , A61K31/495 , A61K31/5377 , C07D233/90 , C07D249/02 , C07D295/15 , C07D295/185 , C07D307/68 , C07D403/12 , C07D405/12 , C07D413/12
Abstract: The present application relates to a-substituted amino acid compounds of the Formula (I), compositions comprising these compounds and their use, in particular for the treatment of diseases, disorders or conditions characterized by or associated with the hypercitrullination of proteins by peptidyl arginine deiminase (PAD) enzymes.
Abstract translation: 本申请涉及式（I）的取代氨基酸化合物，包含这些化合物的组合物及其用途，特别是用于治疗由肽基精氨酸脱亚氨基酶特征性或与蛋白质高蛋白化相关的疾病，病症或病症 （PAD）酶。
-
公开(公告)号：WO2014138979A1
公开(公告)日：2014-09-18
申请号：PCT/CA2014/050222
申请日：2014-03-12
Applicant: CANADIAN BLOOD SERVICES , UNIVERSITY HEALTH NETWORK
Inventor： BRANCH, Donald R. , KOTRA, Lakshmi P.
IPC: C07D231/20 , A61K31/4155 , A61P37/06 , C07D231/12
CPC classification number: A61K31/4155 , A61K45/06 , C07D231/12 , C07D231/20 , C07D231/22 , C07D231/46 , C07D403/06 , C07D403/12
Abstract: The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof; wherein U, R1, R2, R3 and Q are as defined herein. The disclosure also provides a method for treating or preventing a method for the prevention, treatment and/or alleviation of one or more autoimmune or alloimmune disease, pharmaceutical compositions and combination comprising a therapeutically effective amount of a compound, as defined herein.
Abstract translation: 本公开涉及式（I）化合物或其药学上可接受的盐; 其中U，R 1，R 2，R 3和Q如本文所定义。 本公开还提供了用于治疗或预防用于预防，治疗和/或缓解一种或多种自身免疫或同种异体免疫疾病，药物组合物和组合的方法，所述方法包含治疗有效量的本文定义的化合物。
-
Patent Agency Ranking
公开(公告)号：EP3250236A1
公开(公告)日：2017-12-06
申请号：EP16742603.0
申请日：2016-01-26
Applicant: University Health Network
Inventor： KOTRA, Lakshmi P. , PAIGE, Christopher John , BELLO , Angelica Mara , SHERMAN, Igor
IPC: A61K47/42 , A61K31/337 , A61K9/19 , A61P35/00 , C07D305/14 , C07K14/47
CPC classification number: A61K31/337 , A61K9/0019 , A61K9/19 , A61K47/42 , C07D305/14 , C07K14/4715
Abstract: Compositions which comprise a hydro-phobic taxane such as paclitaxel are produced by non-covalent complexing between the taxane and alpha-fetoprotein c at a ratio of about 4 moles of taxane per mole of AFP. The complexes are water soluble and suitable for injection. Uses of the compositions for treating a subject presenting with an AFP receptor positive and taxane responsive ease cell are also disclosed.
-
公开(公告)号：EP2970138B1
公开(公告)日：2019-01-16
申请号：EP14765081.6
申请日：2014-03-12
Applicant: Canadian Blood Services , University Health Network
Inventor： BRANCH, Donald R. , KOTRA, Lakshmi P.
IPC: C07D231/20 , A61K31/4155 , A61P37/06 , C07D231/12 , C07D231/22 , C07D231/46
-
公开(公告)号：EP2970138A1
公开(公告)日：2016-01-20
申请号：EP14765081.6
申请日：2014-03-12
Applicant: Canadian Blood Services , University Health Network
Inventor： BRANCH, Donald R. , KOTRA, Lakshmi P.
IPC: C07D231/20 , A61K31/4155 , A61P37/06 , C07D231/12 , C07D231/22 , C07D231/46
CPC classification number: A61K31/4155 , A61K45/06 , C07D231/12 , C07D231/20 , C07D231/22 , C07D231/46 , C07D403/06 , C07D403/12
Abstract: The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof; wherein U, R1, R2, R3 and Q are as defined herein. The disclosure also provides a method for treating or preventing a method for the prevention, treatment and/or alleviation of one or more autoimmune or alloimmune disease, pharmaceutical compositions and combination comprising a therapeutically effective amount of a compound, as defined herein.
-
公开(公告)号：EP4547650A1
公开(公告)日：2025-05-07
申请号：EP23829326.0
申请日：2023-06-28
Applicant: Canadian Blood Services , University Health Network
Inventor： BRANCH, Donald R. , KOTRA, Lakshmi P. , LEWIS-BAKKER, Melissa
IPC: C07D231/16 , A61K31/427 , A61K31/454 , A61K31/4155 , A61P7/00 , C07D231/12 , C07D231/14 , C07D403/04 , C07D409/14 , C07D417/12
-
公开(公告)号：EP3337791A1
公开(公告)日：2018-06-27
申请号：EP16836314.1
申请日：2016-08-15
Applicant: University Health Network
Inventor： KOTRA, Lakshmi P. , WASILEWSKI, Ewa
IPC: C07D307/54 , A61K31/341 , A61K31/4178 , A61K31/4192 , A61K31/495 , A61K31/5377 , A61P21/00 , A61P25/28 , C07D295/15 , C07D295/185 , C07D403/12 , C07K5/078
CPC classification number: A61K31/5377 , A61K31/341 , A61K31/4178 , A61K31/4192 , A61K31/495 , A61K31/496 , C07D233/90 , C07D249/02 , C07D295/15 , C07D295/185 , C07D307/68 , C07D403/12 , C07D405/12 , C07D413/12
Abstract: The present application relates to a-substituted amino acid compounds of the Formula (I), compositions comprising these compounds and their use, in particular for the treatment of diseases, disorders or conditions characterized by or associated with the hypercitrullination of proteins by peptidyl arginine deiminase (PAD) enzymes.
-
-
-
-
-
-
-
Search Results
8
records
(took 0.023 seconds)
