公开(公告)号：WO2016119045A1

公开(公告)日：2016-08-04

申请号：PCT/CA2016/000023

申请日：2016-01-26

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： KOTRA, Lakshmi P. ,  PAIGE, Christopher John ,  BELLO , Angelica Mara ,  SHERMAN, Igor

IPC: A61K47/42 ,  A61K31/337 ,  A61K9/19 ,  A61P35/00 ,  C07D305/14 ,  C07K14/47

CPC classification number: A61K31/337 ,  A61K9/0019 ,  A61K9/19 ,  A61K47/42 ,  C07D305/14 ,  C07K14/4715

Abstract: Compositions which comprise a hydrophobic taxane such as paclitaxel are produced by non-covalent complexing between the taxane and alpha-fetoprotein c at a ratio of about 4 moles of taxane per mole of AFP. The complexes are water soluble and suitable for injection. Uses of the compositions for treating a subject presenting with an AFP receptor positive and taxane responsive disease cell are also disclosed.

Abstract translation: 包含疏水紫杉烷如紫杉醇的组合物通过紫杉烷和甲胎蛋白c之间的非共价络合产生，每摩尔AFP的比例为约4摩尔紫杉烷。 络合物是水溶性的并且适于注射。 还公开了用于治疗呈现AFP受体阳性和紫杉烷应答疾病细胞的受试者的组合物的用途。

公开(公告)号：EP3250236A1

公开(公告)日：2017-12-06

申请号：EP16742603.0

申请日：2016-01-26

Applicant: University Health Network

Inventor： KOTRA, Lakshmi P. ,  PAIGE, Christopher John ,  BELLO , Angelica Mara ,  SHERMAN, Igor

IPC: A61K47/42 ,  A61K31/337 ,  A61K9/19 ,  A61P35/00 ,  C07D305/14 ,  C07K14/47

CPC classification number: A61K31/337 ,  A61K9/0019 ,  A61K9/19 ,  A61K47/42 ,  C07D305/14 ,  C07K14/4715

Abstract: Compositions which comprise a hydro-phobic taxane such as paclitaxel are produced by non-covalent complexing between the taxane and alpha-fetoprotein c at a ratio of about 4 moles of taxane per mole of AFP. The complexes are water soluble and suitable for injection. Uses of the compositions for treating a subject presenting with an AFP receptor positive and taxane responsive ease cell are also disclosed.