公开(公告)号：WO2023057931A1

公开(公告)日：2023-04-13

申请号：PCT/IB2022/059520

申请日：2022-10-05

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： DE CARVALHO, Daniel Diniz ,  LOO YAU, Helen ,  ETTAYEBI, Ilias

IPC: A61K35/14 ,  A61K35/17 ,  A61P35/00 ,  C12N5/10 ,  C12N5/078 ,  C12N15/10 ,  C12N15/12 ,  C12N15/54 ,  C12N15/62 ,  C12N15/113

Abstract: The present disclosure is directed to methods of treating a subject in need thereof, comprising administering to the subject a population of modified immune cells, which comprises one or more modified immune cells having decreased expression of one or more components of the SAGA (Spt–Ada–Gcn5–acetyltransferase) complex, relative to an unmodified immune cell. In some aspects, the immune cell comprises a chimeric antigen receptor or a T cell receptor. In some aspects, the immune cell is a T cell, an NK cell, or a tumor infiltrating lymphocyte (TIL).

公开(公告)号：WO2021203200A1

公开(公告)日：2021-10-14

申请号：PCT/CA2021/050464

申请日：2021-04-07

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： DINIZ DE CARVALHO, Daniel ,  HE, Housheng ,  ETTAYEBI, Ilias ,  SOARES, Fraser ,  LOO YAU, Helen

IPC: C12N5/10 ,  A61K31/7088 ,  A61K31/7105 ,  A61K35/17 ,  A61K38/46 ,  A61P35/00 ,  A61P37/02 ,  C07K19/00 ,  C12N15/113 ,  C12N15/54 ,  C12N15/62 ,  C12N15/63 ,  C12N5/0783 ,  C12N9/22

Abstract: Methods of increasing T cell effector function in a T cell population are provided that involve inhibiting one or more genetic subunits of the SAGA (Spt-Ada-Gcn5-acetyltransferase) gene regulation complex in the T cell population. Also provided are methods of using such T cell populations in the treatment of cancer patients.

公开(公告)号：EP4412626A1

公开(公告)日：2024-08-14

申请号：EP22878051.6

申请日：2022-10-05

Applicant: University Health Network

Inventor： DINIZ DE CARVALHO, Daniel ,  LOO YAU, Helen ,  ETTAYEBI, Ilias

IPC: A61K35/14 ,  A61K35/17 ,  A61P35/00 ,  C12N5/10 ,  C12N5/078 ,  C12N15/10 ,  C12N15/12 ,  C12N15/54 ,  C12N15/62 ,  C12N15/113

CPC classification number: A61K35/17 ,  A61P35/00 ,  C07K14/435 ,  C12N15/113 ,  C12N9/1029 ,  C12N9/16 ,  C07K14/4702 ,  C12N15/63 ,  C12Y304/19012 ,  C12Y203/01048 ,  C07K14/7051 ,  C07K2319/0320130101 ,  C12N15/1137 ,  C12N2310/2020170501 ,  C12N5/0636 ,  C12N2510/0020130101 ,  C12N2501/51520130101 ,  C12N2501/5320130101 ,  C12N2501/5120130101 ,  A61K45/06

公开(公告)号：EP4133059A1

公开(公告)日：2023-02-15

申请号：EP21784330.9

申请日：2021-04-07

Applicant: University Health Network

Inventor： DINIZ DE CARVALHO, Daniel ,  HE, Housheng ,  ETTAYEBI, Ilias ,  SOARES, Fraser ,  LOO YAU, Helen

IPC: C12N5/10 ,  A61K31/7088 ,  A61K31/7105 ,  A61K35/17 ,  A61K38/46 ,  A61P35/00 ,  A61P37/02 ,  C07K19/00 ,  C12N15/113 ,  C12N15/54 ,  C12N15/62 ,  C12N15/63 ,  C12N5/0783 ,  C12N9/22