公开(公告)号：WO2021203200A1

公开(公告)日：2021-10-14

申请号：PCT/CA2021/050464

申请日：2021-04-07

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： DINIZ DE CARVALHO, Daniel ,  HE, Housheng ,  ETTAYEBI, Ilias ,  SOARES, Fraser ,  LOO YAU, Helen

IPC: C12N5/10 ,  A61K31/7088 ,  A61K31/7105 ,  A61K35/17 ,  A61K38/46 ,  A61P35/00 ,  A61P37/02 ,  C07K19/00 ,  C12N15/113 ,  C12N15/54 ,  C12N15/62 ,  C12N15/63 ,  C12N5/0783 ,  C12N9/22

Abstract: Methods of increasing T cell effector function in a T cell population are provided that involve inhibiting one or more genetic subunits of the SAGA (Spt-Ada-Gcn5-acetyltransferase) gene regulation complex in the T cell population. Also provided are methods of using such T cell populations in the treatment of cancer patients.

公开(公告)号：EP4133059A1

公开(公告)日：2023-02-15

申请号：EP21784330.9

申请日：2021-04-07

Applicant: University Health Network

Inventor： DINIZ DE CARVALHO, Daniel ,  HE, Housheng ,  ETTAYEBI, Ilias ,  SOARES, Fraser ,  LOO YAU, Helen

IPC: C12N5/10 ,  A61K31/7088 ,  A61K31/7105 ,  A61K35/17 ,  A61K38/46 ,  A61P35/00 ,  A61P37/02 ,  C07K19/00 ,  C12N15/113 ,  C12N15/54 ,  C12N15/62 ,  C12N15/63 ,  C12N5/0783 ,  C12N9/22