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公开(公告)号：WO2013082702A1
公开(公告)日：2013-06-13
申请号：PCT/CA2012/001122
申请日：2012-12-05
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： ZHENG, Gang , LOVELL, Jonathan , HUYNH, Elizabeth
CPC classification number: C12Q1/6806 , A61K41/0028 , B01J13/02 , C12N11/04 , C12N13/00 , C12N15/88 , C12P1/00 , G01N1/28 , Y10T436/143333
Abstract: There is provided herein vesicles comprising a bilayer comprising porphyrin-phospholipid conjugate, wherein the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipids, wherein the vesicle is 1-100 microns in diameter.
Abstract translation: 提供了包含包含卟啉 - 磷脂缀合物的双层的囊泡，其中卟啉 - 磷脂缀合物包含共价连接到脂质侧链上的卟啉，卟啉衍生物或卟啉类似物，优选在sn-1或sn-2位， 的一种磷脂，其中囊泡的直径为1-100微米。
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公开(公告)号：WO2012167350A1
公开(公告)日：2012-12-13
申请号：PCT/CA2012/000500
申请日：2012-05-25
Applicant: UNIVERSITY HEALTH NETWORK , ZHENG, Gang , LOVELL, Jonathan
Inventor： ZHENG, Gang , LOVELL, Jonathan
IPC: A61K9/127 , A61K31/704 , A61K47/22 , A61K49/00 , A61K51/12 , A61K9/14 , B01J13/02 , C12P17/18 , C12P41/00 , C07F9/6561
CPC classification number: C12P17/182 , A61K8/14 , A61K8/553 , A61K31/704 , A61K41/0071 , A61K47/544 , A61K2800/10 , A61Q19/00 , B01J13/02 , C07F9/106 , C07F9/6561 , C09B67/0097 , C09B69/108
Abstract: There is herein described a nanovesicle comprising a bilayer of porphyrin-phospholipid conjugates. Each porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain at one of the sn-1 or the sn-2 positions of one phospholipid. Further, the nanovesicle has a defined regioisomeric ratio of sn-1:sn-2 porphyrin-phospholipid conjugates.
Abstract translation: 本文描述了包含卟啉 - 磷脂共轭物双层的纳米囊。 每个卟啉 - 磷脂缀合物包含一个卟啉，卟啉衍生物或卟啉类似物，其共价连接到一个磷脂的sn-1或sn-2位置之一的脂质侧链。 此外，纳米囊具有定义的sn-1：sn-2卟啉 - 磷脂缀合物的区域异构体比例。
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Patent Agency Ranking3.发明申请PORPHYRIN-PHOSPHOLIPID CONJUGATE MICROBUBBLES AND THEIR USE AS CONTRAST AGENTS. 审中-公开PORPHYRIN-PHOSPHOLIPID CONJUGATE MICROBUBBLE AND AND THE USE as CONTRAST AGENTS。
公开(公告)号：WO2013053042A1
公开(公告)日：2013-04-18
申请号：PCT/CA2012/000937
申请日：2012-10-11
Applicant: UNIVERSITY HEALTH NETWORK , ZHENG, Gang , LOVELL, Jonathan , HUYNH, Elizabeth
Inventor： ZHENG, Gang , LOVELL, Jonathan , HUYNH, Elizabeth
CPC classification number: A61B8/481 , A61B5/0095 , A61K9/14 , A61K47/22 , A61K47/24 , A61K49/048 , A61K49/223
Abstract: The present invention relates to a microbubble comprising a monolayer of porphyrin-phospholipid conjugate, said microbubble having encapsulated therein, and to the use of said microbubble in ultrasound imaging of a target area in a subject.
Abstract translation: 本发明涉及包含单层卟啉 - 磷脂缀合物的微泡，所述微泡封装在其中，以及所述微泡在受试者的靶区域的超声成像中的用途。
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公开(公告)号：EP2788508A1
公开(公告)日：2014-10-15
申请号：EP12855406.0
申请日：2012-12-05
Applicant: University Health Network
Inventor： ZHENG, Gang , LOVELL, Jonathan , HUYNH, Elizabeth
CPC classification number: C12Q1/6806 , A61K41/0028 , B01J13/02 , C12N11/04 , C12N13/00 , C12N15/88 , C12P1/00 , G01N1/28 , Y10T436/143333
Abstract: There is provided herein vesicles comprising a bilayer comprising porphyrin-phospholipid conjugate, wherein the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipids, wherein the vesicle is 1-100 microns in diameter.
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公开(公告)号：EP2717857A1
公开(公告)日：2014-04-16
申请号：EP12796842.8
申请日：2012-05-25
Applicant: University Health Network (UHN)
Inventor： ZHENG, Gang , LOVELL, Jonathan
IPC: A61K9/127 , A61K31/704 , A61K47/22 , A61K49/00 , A61K51/12 , A61K9/14 , B01J13/02 , C12P17/18 , C12P41/00 , C07F9/6561
CPC classification number: C12P17/182 , A61K8/14 , A61K8/553 , A61K31/704 , A61K41/0071 , A61K47/544 , A61K2800/10 , A61Q19/00 , B01J13/02 , C07F9/106 , C07F9/6561 , C09B67/0097 , C09B69/108
Abstract: There is herein described a nanovesicle comprising a bilayer of porphyrin-phospholipid conjugates. Each porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain at one of the sn-1 or the sn-2 positions of one phospholipid. Further, the nanovesicle has a defined regioisomeric ratio of sn-1:sn-2 porphyrin-phospholipid conjugates.
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公开(公告)号：EP2717857B1
公开(公告)日：2018-07-11
申请号：EP12796842.8
申请日：2012-05-25
Applicant: University Health Network (UHN)
Inventor： ZHENG, Gang , LOVELL, Jonathan
IPC: A61K9/127 , A61K31/704 , A61K47/22 , A61K49/00 , A61K51/12 , A61K9/14 , B01J13/02 , C12P17/18 , C12P41/00 , C07F9/6561 , A61K8/55 , A61K41/00 , A61K47/54 , A61K8/14 , C07F9/10 , C09B67/02 , C09B69/10 , A61Q19/00
CPC classification number: C12P17/182 , A61K8/14 , A61K8/553 , A61K31/704 , A61K41/0071 , A61K47/544 , A61K2800/10 , A61Q19/00 , B01J13/02 , C07F9/106 , C07F9/6561 , C09B67/0097 , C09B69/108
Abstract: There is herein described a nanovesicle comprising a bilayer of porphyrin-phospholipid conjugates. Each porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain at one of the sn-1 or the sn-2 positions of one phospholipid. Further, the nanovesicle has a defined regioisomeric ratio of sn-1:sn-2 porphyrin-phospholipid conjugates.
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7.发明公开PORPHYRIN-PHOSPHOLIPID CONJUGATE MICROBUBBLES AND THEIR USE AS CONTRAST AGENTS. 审中-公开卟啉PHOSPHOLIPIDKONJUGAT微小气泡及其作为造影剂
公开(公告)号：EP2766051A1
公开(公告)日：2014-08-20
申请号：EP12840663.4
申请日：2012-10-11
Applicant: University Health Network
Inventor： ZHENG, Gang , LOVELL, Jonathan , HUYNH, Elizabeth
CPC classification number: A61B8/481 , A61B5/0095 , A61K9/14 , A61K47/22 , A61K47/24 , A61K49/048 , A61K49/223
Abstract: The present invention relates to a microbubble comprising a monolayer of porphyrin-phospholipid conjugate, said microbubble having encapsulated therein, and to the use of said microbubble in ultrasound imaging of a target area in a subject.
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