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公开(公告)号：WO2015132675A3
公开(公告)日：2015-09-11
申请号：PCT/IB2015/001033
申请日：2015-03-06
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： MAK, Tak, W.
IPC: A61K39/395 , A61K38/17 , A61P35/00 , A61P37/00
Abstract: The present invention is directed to methods and compositions for modulating proteins involved in the immune response, specifically by modulating the expression and/or activity of the Toso protein. The present invention further provides methods and compositions for treatment of autoimmune disease and cancer by modulating the expression and/or activity of the Toso protein.
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公开(公告)号：WO2013136193A2
公开(公告)日：2013-09-19
申请号：PCT/IB2013/001179
申请日：2013-03-14
Applicant: UNIVERSITY HEALTH NETWORK , TUSCHE, Michael, W. , MAK, Tak, W. , OHASHI, Pamela, S. , LANG, Philipp , LANG, Karl , BRENNER, Dirk , LIN, Gloria
Inventor： TUSCHE, Michael, W. , MAK, Tak, W. , OHASHI, Pamela, S. , LANG, Philipp , LANG, Karl , BRENNER, Dirk , LIN, Gloria
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
Abstract translation: 本发明进一步涉及用于调节Toso蛋白活性的方法和组合物。 本发明还包括使用包括可溶性Toso蛋白的组合物治疗与炎症，自身免疫疾病和癌症相关的病症。
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3.发明申请METHODS AND COMPOSITIONS FOR DETECTION OF TARGETS INVOLVED IN CANCER METASTASIS 审中-公开用于检测癌症METASTASIS中涉及的靶标的方法和组合物
公开(公告)号：WO2015132672A2
公开(公告)日：2015-09-11
申请号：PCT/IB2015/000996
申请日：2015-03-06
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： BLASER, Heiko , MAK, Tak, W.
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , A61K38/177 , A61K39/39541 , A61K39/39558 , A61K49/0008 , A61K2039/505 , A61K2039/507 , C07K14/70503 , C07K16/2818 , C07K2317/76 , C12N15/1135 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/5088 , G01N2333/82 , A61K2300/00
Abstract: The present invention is further directed to methods and compositions for identifying target nucleic acids that are involved in cancer metastasis.
Abstract translation: 本发明还涉及用于鉴定参与癌症转移的靶核酸的方法和组合物。
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Patent Agency Ranking4.发明申请
公开(公告)号：WO2015132670A2
公开(公告)日：2015-09-11
申请号：PCT/IB2015/000912
申请日：2015-03-07
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： HERSHENFIELD, Brian , MAK, Tak, W.
IPC: C04B30/00
CPC classification number: C12Q1/6883 , A61K38/177 , A61K39/39541 , A61K39/39558 , A61K49/0008 , A61K2039/505 , A61K2039/507 , C07K14/70503 , C07K16/2818 , C07K2317/76 , C12N15/1135 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/5088 , G01N2333/82 , A61K2300/00
Abstract: The present invention is directed to methods and compositions for identifying targets for induction of self-tolerance and treatment of autoimmune disease.
Abstract translation: 本发明涉及用于鉴定诱导自身免疫性疾病和治疗自身免疫性疾病的靶标的方法和组合物。
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公开(公告)号：WO2015000059A1
公开(公告)日：2015-01-08
申请号：PCT/CA2014/000537
申请日：2014-07-02
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： MAK, Tak, W. , LAI, Xiuqiu , TUSCHE, Michael, W.
CPC classification number: C07K16/2803 , C07K2317/622
Abstract: The present invention provides methods and compositions for modulating Toso activity and treating diseases and disorders in which Toso is implicated. Such methods and compositions include the use of one or more antibodies that bind to a Toso protein or to a ligand of a Toso protein.
Abstract translation: 本发明提供了用于调节Toso活性并治疗涉及Toso的疾病和病症的方法和组合物。 这样的方法和组合物包括使用结合Toso蛋白质或Toso蛋白质配体的一种或多种抗体。
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公开(公告)号：EP3016982A1
公开(公告)日：2016-05-11
申请号：EP14820663.4
申请日：2014-07-02
Applicant: University Health Network
Inventor： MAK, Tak, W. , LAI, Xiuqiu , TUSCHE, Michael, W.
CPC classification number: C07K16/2803 , C07K2317/622
Abstract: The present invention provides methods and compositions for modulating Toso activity and treating diseases and disorders in which Toso is implicated. Such methods and compositions include the use of one or more antibodies that bind to a Toso protein or to a ligand of a Toso protein.
Abstract translation: 本发明提供了用于调节Toso活性和治疗涉及Toso的疾病和病症的方法和组合物。 这样的方法和组合物包括使用一种或多种与Toso蛋白质或Toso蛋白质的配体结合的抗体。
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7.发明公开METHODS AND COMPOSITIONS FOR MODULATING TOSO ACTIVITY 有权VERFAHREN UND ZUSAMMENSETZUNGEN ZUR MODULIERUNG DER TOSO-AKTIVITÄT
公开(公告)号：EP2825191A2
公开(公告)日：2015-01-21
申请号：EP13734483.4
申请日：2013-03-14
Applicant: University Health Network
Inventor： TUSCHE, Michael, W. , MAK, Tak, W. , OHASHI, Pamela, S. , LANG, Philipp , BRENNER, Dirk , LIN, Gloria
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
Abstract translation: 本发明进一步涉及用于调节Toso蛋白活性的方法和组合物。 本发明还包括使用包括可溶性Toso蛋白质的组合物治疗与炎症，自身免疫性疾病和癌症相关的疾病。
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公开(公告)号：EP2825191B1
公开(公告)日：2019-08-28
申请号：EP13734483.4
申请日：2013-03-14
Applicant: University Health Network
Inventor： TUSCHE, Michael, W. , MAK, Tak, W. , OHASHI, Pamela, S. , LANG, Philipp , BRENNER, Dirk , LIN, Gloria
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