公开(公告)号：WO2019046949A1

公开(公告)日：2019-03-14

申请号：PCT/CA2018/051086

申请日：2018-09-07

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： MASON, Jacqueline M. ,  BRAY, Mark R. ,  MAK, Tak Wah ,  FLETCHER, Graham

IPC: A61K31/5377 ,  A61K39/395 ,  A61P35/00 ,  C07D413/10

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula (Formula (I)) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

公开(公告)号：EP3678669A1

公开(公告)日：2020-07-15

申请号：EP18854876.2

申请日：2018-09-07

Applicant: University Health Network

Inventor： MASON, Jacqueline M. ,  BRAY, Mark R. ,  MAK, Tak Wah ,  FLETCHER, Graham

IPC: A61K31/5377 ,  A61K39/395 ,  A61P35/00 ,  C07D413/10