公开(公告)号：WO2021108918A1

公开(公告)日：2021-06-10

申请号：PCT/CA2020/051668

申请日：2020-12-04

Applicant: UNIVERSITY HEALTH NETWORK ,  BRAY, Mark R. ,  MASON, Jacqueline M. ,  FLETCHER, Graham

Inventor： BRAY, Mark R. ,  MASON, Jacqueline M. ,  FLETCHER, Graham

IPC: A61K31/5377 ,  A61K31/194 ,  A61P35/02 ,  C07C57/15 ,  C07D413/14

Abstract: The invention is related to a method of treating a subject with acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, non-Hodgkin's lymphoma, Burkitt lymphoma, or diffuse large B-cell lymphoma, or myelodysplastic syndrome by administration of Compound (I): (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：WO2021203190A1

公开(公告)日：2021-10-14

申请号：PCT/CA2021/050452

申请日：2021-04-05

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： FLETCHER, Graham ,  MASON, Jacqueline M. ,  BRAY, Mark R.

IPC: A61K31/5377 ,  A61K39/395 ,  A61P35/00 ,  C07D413/10 ,  C07K16/28

Abstract: Provided herein are methods of treating triple negative breast cancer using an effective amount of Compound (I) represented by the formula: or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor, wherein the checkpoint inhibitor is a PD-1 inhibitor or a PD-L1 inhibitor. Uses of an effective amount of Compound [I] and an effective amount of an immune checkpoint inhibitor, wherein the checkpoint inhibitor is a PD-1inhibitor or a PD-L1 inhibitor for treating triple negative breast cancer are also provided herein.

公开(公告)号：WO2019046949A1

公开(公告)日：2019-03-14

申请号：PCT/CA2018/051086

申请日：2018-09-07

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： MASON, Jacqueline M. ,  BRAY, Mark R. ,  MAK, Tak Wah ,  FLETCHER, Graham

IPC: A61K31/5377 ,  A61K39/395 ,  A61P35/00 ,  C07D413/10

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula (Formula (I)) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

公开(公告)号：WO2019023799A1

公开(公告)日：2019-02-07

申请号：PCT/CA2018/050936

申请日：2018-08-01

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： BRAY, Mark Robert ,  MASON, Jacqueline M. ,  MAK, Tak W. ,  FLETCHER, Graham

IPC: A61K31/519 ,  A61K39/395 ,  A61P35/00 ,  C07D487/04 ,  C07K16/18

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

公开(公告)号：WO2019023786A1

公开(公告)日：2019-02-07

申请号：PCT/CA2017/050920

申请日：2017-08-01

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： BRAY, Mark Robert ,  MASON, Jacqueline M. ,  MAK, Tak W. ,  FLETCHER, Graham

IPC: A61K31/519 ,  A61K39/395 ,  A61P35/00 ,  A61P37/02 ,  C07D487/04 ,  C07K16/28 ,  C07K16/30

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

公开(公告)号：EP4069246A1

公开(公告)日：2022-10-12

申请号：EP20895810.8

申请日：2020-12-04

Applicant: University Health Network

Inventor： BRAY, Mark R. ,  MASON, Jacqueline M. ,  FLETCHER, Graham

IPC: A61K31/5377 ,  A61K31/194 ,  A61P35/02 ,  C07C57/15 ,  C07D413/14

公开(公告)号：EP3678669A1

公开(公告)日：2020-07-15

申请号：EP18854876.2

申请日：2018-09-07

Applicant: University Health Network

Inventor： MASON, Jacqueline M. ,  BRAY, Mark R. ,  MAK, Tak Wah ,  FLETCHER, Graham

IPC: A61K31/5377 ,  A61K39/395 ,  A61P35/00 ,  C07D413/10