公开(公告)号：WO2023044583A1

公开(公告)日：2023-03-30

申请号：PCT/CA2022/051424

申请日：2022-09-26

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： KESHAVJEE, Shafique ,  SAGE, Andrew ,  CYPEL, Marcelo ,  MARTINU, Tereza

IPC: G01N33/50 ,  G01N33/52

Abstract: Methods, kits and devices for assessing bile acid in a donor lung and/or a transplant recipient are described. The methods involve obtaining from the donor lung or transplant recipient a bronchial wash sample, optionally a bronchoalveolar lavage (BAL) sample or a large airway bronchial wash (LABW) sample; measuring in the bronchial wash sample the level of bile acid and optionally one or more inflammation markers, comparing biomarker levels with a control or cut-off level, wherein a differential biomarker level is indicative of an outcome of the donor lung or transplant recipient, including risk of aspiration, suitability of the donor lung, or risk of a particular outcome in the transplant recipient.

公开(公告)号：EP4405678A1

公开(公告)日：2024-07-31

申请号：EP22871235.2

申请日：2022-09-26

Applicant: University Health Network

Inventor： KESHAVJEE, Shafique ,  SAGE, Andrew ,  CYPEL, Marcelo ,  MARTINU, Tereza

IPC: G01N33/50 ,  G01N33/52

CPC classification number: G01N33/92 ,  G01N2800/2420130101 ,  G01N2800/5020130101 ,  G01N33/6869 ,  G01N2333/52120130101 ,  G01N2333/5420130101 ,  G01N2333/541220130101 ,  G01N2333/542120130101 ,  G01N2800/0620130101 ,  G01N33/6893 ,  G01N33/54387