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    BIOMARKER COMBINATIONS IN EX VIVO LUNG PERFUSION (EVLP) PERFUSATE
    1.
    发明申请
    BIOMARKER COMBINATIONS IN EX VIVO LUNG PERFUSION (EVLP) PERFUSATE 审中-公开

    公开(公告)号：WO2020118452A1

    公开(公告)日：2020-06-18

    申请号：PCT/CA2019/051813

    申请日：2019-12-13

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： KESHAVJEE, Shafique ,  LIU, Mingyao ,  CYPEL, Marcelo ,  SAGE, Andrew

    IPC: G01N33/48 ,  G01N33/53 ,  G01N33/543 ,  G06F16/90 ,  G06N20/00

    Abstract: Methods and kits for screening, diagnosing, detecting or predicting a patient outcome/risk variable for a lung transplant recipient after transplant or an EVLP outcome by measuring biomarker levels of at least three biomarkers selected from IL-6, IL-8, IL-10 and IL-1β optionally in combination with one or both of sTNFR1 and sTREM1 in EVLP perfusate are described. The methods involve for example, i. obtaining one or more test EVLP perfusate samples of a donor lung; ii. determining in one or more test EVLP perfusate sample of a donor lung, a polypeptide level of the at least three biomarkers selected from IL-8, IL-6, IL-10 and IL-1β and optionally one or both of sTNFR1 and sTREM1 i; and iii. a) comparing the one or more parameter values related to a level of the at least three biomarkers in the perfusate sample with control EVLP data or a cut-off level, wherein the differential level is indicative of outcome/risk of after transplant or of an EVLP outcome; or b) using the one or more parameter values related to a level of the at least three biomarkers in combination, as part of an algebraic calculation or model of outcome/risk.

    SCREENING DONOR LUNGS FOR LUNG TRANSPLANTATION
    2.
    发明申请
    SCREENING DONOR LUNGS FOR LUNG TRANSPLANTATION 审中-公开

    公开(公告)号：WO2023044583A1

    公开(公告)日：2023-03-30

    申请号：PCT/CA2022/051424

    申请日：2022-09-26

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： KESHAVJEE, Shafique ,  SAGE, Andrew ,  CYPEL, Marcelo ,  MARTINU, Tereza

    IPC: G01N33/50 ,  G01N33/52

    Abstract: Methods, kits and devices for assessing bile acid in a donor lung and/or a transplant recipient are described. The methods involve obtaining from the donor lung or transplant recipient a bronchial wash sample, optionally a bronchoalveolar lavage (BAL) sample or a large airway bronchial wash (LABW) sample; measuring in the bronchial wash sample the level of bile acid and optionally one or more inflammation markers, comparing biomarker levels with a control or cut-off level, wherein a differential biomarker level is indicative of an outcome of the donor lung or transplant recipient, including risk of aspiration, suitability of the donor lung, or risk of a particular outcome in the transplant recipient.

    BIOMARKERS FOR DETECTING OF OUTCOME/RISK OF THE PATIENTS WITH A RESPIRATORY ILLNESS
    3.
    发明申请
    BIOMARKERS FOR DETECTING OF OUTCOME/RISK OF THE PATIENTS WITH A RESPIRATORY ILLNESS 审中-公开

    公开(公告)号：WO2021179096A

    公开(公告)日：2021-09-16

    申请号：PCT/CA2021/050343

    申请日：2021-03-15

    Applicant: UNIVERSITY HEALTH NETWORK [CA]/[CA]

    Inventor： SAGE, Andrew ,  VALERO, Jerome ,  DEL SORBO, Lorenzo ,  CYPEL, Marcelo ,  WANG, Bo ,  KESHAVJEE, Shafique

    IPC: G01N33/48 ,  G01N33/53 ,  G01N33/543 ,  G16H50/30

    Abstract: Methods and kits for screening, diagnosing, detecting or predicting a patient outcome/risk in a patient with a respiratory illness, the method comprising: a. obtaining a sample obtained from the patient; b. quantitatively measuring in the sample a polypeptide level of one or more biomarkers selected from: IL-6, CXCL8, IL-10, IL-1RA, IL-2, IL-4, IL-7, IL-9, IL-13, IL-17, IFN-g, IP-10, MCP-1, G-CSF, GM-CSF, FGF-basic, SCGF-β, GRO-α, MIP1-α, MIP1-β, CK-18, PDGF-bb, caspase 3, HMGB-1, TNF α, VEGF, sTNFR1 and sTREM1; and c. i) comparing the level of the one or more biomarkers in the sample with a control or cut-off level, wherein the differential level is indicative of patient outcome risk; or ii) using the polypeptide level of several of the biomarkers in combination, as inputs for an algebraic calculation or machine learning model of patient outcome risk.

    BIOMARKERS IN EX VIVO LUNG PERFUSION (EVLP) PERFUSATE
    4.
    发明申请
    BIOMARKERS IN EX VIVO LUNG PERFUSION (EVLP) PERFUSATE 审中-公开

    公开(公告)号：WO2019023790A1

    公开(公告)日：2019-02-07

    申请号：PCT/CA2018/050922

    申请日：2018-07-30

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： KESHAVJEE, Shafique ,  LIU, Mingyao ,  CYPEL, Marcelo ,  SAGE, Andrew

    IPC: G01N33/48 ,  A61B5/00 ,  G01N33/53 ,  G01N33/543

    Abstract: Methods and kits for screening, diagnosing, detecting or predicting a patient outcome/risk variable for a lung transplant recipient after transplant or an EVLP outcome by measuring biomarker levels of one or more biomarkers selected from IL-6, IL-8, sTNFR1 and sTREM-1 in EVLP perfusate are described. The methods involve for example, i. obtaining one or more test EVLP perfusate samples of a donor lung; ii. determining in one or more test EVLP perfusate sample of a donor lung, a polypeptide level of one or more biomarkers selected from IL-8, IL-6, sTNFR1 and sTREM-1; and iii. a) comparing the polypeptide level of the one or more biomarkers in the perfusate sample with a control or cut-off level, wherein the differential level is indicative of outcome/risk of after transplant or of an EVLP outcome; or b) using the polypeptide level of one or several of the one or more biomarkers in combination, as part of an algebraic calculation of outcome/risk.

    ELECTROCHEMICAL ASSAY FOR A PROTEIN ANALYTE
    5.
    发明申请
    ELECTROCHEMICAL ASSAY FOR A PROTEIN ANALYTE 审中-公开
    电化学分析蛋白质分析

    公开(公告)号：WO2017063074A1

    公开(公告)日：2017-04-20

    申请号：PCT/CA2016/000259

    申请日：2016-10-14

    Applicant: UNIVERSITY HEALTH NETWORK (UHN) ,  THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

    Inventor： KESHAVJEE, Shaf ,  LIU, Mingyao ,  SAGE, Andrew ,  SARGENT, Edward ,  KELLEY, Shana

    IPC: G01N27/416 ,  G01N27/327 ,  G01N33/543 ,  G01N27/30

    CPC classification number: G01N33/5438 ,  B82Y30/00 ,  G01N27/3276 ,  G01N27/3278

    Abstract: There is described herein a method for the electrochemical quantification of a protein analyte in sample, comprising: providing one or more electrode(s), each comprising at least one peptide attached to its surface, the peptide being the protein or a fragment thereof; contacting the sample and electrode with an antibody in the presence of a redox reporter, wherein the antibody is capable of binding to each of the protein analyte and the peptide on the electrode; measuring an electrochemical signal generated by the redox reporter when a potential is applied; quantifying the protein analyte by comparing the electrochemical signal generated with a control, wherein the electrochemical signal is indirectly proportional to the amount of protein analyte in the sample.

    Abstract translation: 本文描述了用于样品中蛋白质分析物的电化学定量的方法，其包括：提供一个或多个电极，每个电极包含至少一个连接至其表面的肽，所述肽为 该蛋白质或其片段; 在氧化还原报道分子存在下使样品和电极与抗体接触，其中所述抗体能够与电极上的每种蛋白质分析物和肽结合; 测量当施加电位时由氧化还原报道分子产生的电化学信号; 通过比较用对照产生的电化学信号来量化蛋白质分析物，其中电化学信号与样品中蛋白质分析物的量间接成比例。

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