公开(公告)号：WO2021108926A1

公开(公告)日：2021-06-10

申请号：PCT/CA2020/051682

申请日：2020-12-07

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： ZHANG, Li ,  LEE, Jong Bok ,  VASIC, Daniel ,  KHATRI, Ismat ,  LY, Dalam ,  LEUNG, Yuki Sze Long

IPC: C12N5/10 ,  A61K35/17 ,  A61P35/00 ,  C07K14/705 ,  C07K19/00 ,  C12N15/62 ,  C12N15/85 ,  C12N5/0783

Abstract: The disclosure relates to the development and use of CD4- CD8- double negative T (DNT) cells genetically modified to bind to one or more target antigens to enhance DNT cell anti-cancer activity such as with a chimeric antigen receptor (CAR). Genetically modified DNT cells can be generated ex vivo and expanded from allogeneic healthy donor cells and used as off-the-shelf therapy to overcome allogeneic graft-versus-host disease (GvHD) and/or host-versus-graft rejection in the treatment of cancer.

公开(公告)号：EP4069831A1

公开(公告)日：2022-10-12

申请号：EP20896982.4

申请日：2020-12-07

Applicant: University Health Network

Inventor： ZHANG, Li ,  LEE, Jong Bok ,  VASIC, Daniel ,  KHATRI, Ismat ,  LY, Dalam ,  LEUNG, Yuki Sze Long

IPC: C12N5/10 ,  A61K35/17 ,  A61P35/00 ,  C07K14/705 ,  C07K19/00 ,  C12N15/62 ,  C12N15/85 ,  C12N5/0783