公开(公告)号：WO2017049403A1

公开(公告)日：2017-03-30

申请号：PCT/CA2016/051112

申请日：2016-09-22

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： ZARRINE-AFSAR, Arash ,  JAFFRAY, David A. ,  TATA, Alessandra ,  WOOLMAN, Michael ,  VITKIN, I. Alex

IPC: G01N27/00 ,  A61B10/02 ,  A61B18/20 ,  G01N21/21 ,  H01J49/04 ,  H01J49/16 ,  G01N1/30

CPC classification number: G01N21/21 ,  A61B10/0233 ,  A61B18/20 ,  H01J49/0004

Abstract: Various embodiments are described herein for a system and a method for obtaining samples of tissue for analysis by mass spectrometry. A region of interest can be identified in tissue using image data from a first imaging modality that is other than mass spectrometry. At least one tissue sample can be acquired using a tissue sampler from a sampling location related to the region of interest. Mass spectrum data can be generated for the acquired tissue samples using a mass spectrometer. In some embodiments, polarimetry may be used on a tissue slice, mass spectrometry may be performed on the same tissue slice and then H&E imaging may be performed on the same tissue slice.

Abstract translation: 本文描述了用于通过质谱法获得用于分析的组织样品的系统和方法。 可以使用来自不同于质谱的第一成像模态的图像数据在组织中鉴定感兴趣区域。 可以使用来自与感兴趣区域相关的采样位置的组织取样器获取至少一个组织样本。 可以使用质谱仪对采集的组织样品产生质谱数据。 在一些实施例中，可以在组织切片上使用偏振测定法，可以在相同的组织切片上进行质谱分析，然后可以在相同的组织切片上进行H＆E成像。