公开(公告)号：WO2022109737A1

公开(公告)日：2022-06-02

申请号：PCT/CA2021/051683

申请日：2021-11-24

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： XIE, Stephanie ,  DICK, John

IPC: A61K31/661 ,  A61K31/137 ,  A61P35/00 ,  A61P35/02 ,  C40B30/04 ,  C12Q1/6809 ,  G01N33/574

Abstract: There is described herein methods of treating a hematological cancer in a patient, the method comprising administering to the patient a therapeutically effective amount of a sphingosine-1-phosphate pathway modulator.

公开(公告)号：WO2017190214A1

公开(公告)日：2017-11-09

申请号：PCT/CA2017/000107

申请日：2017-05-03

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： DICK, John ,  XIE, Stephanie ,  LAURENTI, Elisa ,  PRAT, Laura Garcia ,  FERRARI, Robin Thomas

IPC: C12N5/0789 ,  C12N5/02 ,  C12N5/078

Abstract: There is described herein a method for improving or preserving hematopoietic stem cell (HSC) self-renewal during ex-vivo expansion of a population of cells comprising HSCs in an expansion medium, the method comprising culturing the population of cells in the presence of N-(4hydroxyphenyl)retinarnide (4HPR).

Abstract translation: 本文描述了在扩增培养基中包含HSC的细胞群离体扩增期间改善或保存造血干细胞（HSC）自我更新的方法，所述方法包括培养群体 细胞在N-（4-羟基苯基）视黄酰胺（4HPR）存在下。

公开(公告)号：EP3452581A1

公开(公告)日：2019-03-13

申请号：EP17792305.9

申请日：2017-05-03

Applicant: University Health Network

Inventor： DICK, John ,  XIE, Stephanie ,  LAURENTI, Elisa ,  PRAT, Laura Garcia ,  FERRARI, Robin Thomas

IPC: C12N5/0789 ,  C12N5/02 ,  C12N5/078