公开(公告)号：WO1995006250A1

公开(公告)日：1995-03-02

申请号：PCT/US1994009416

申请日：1994-08-25

Applicant: UNIVERSITY OF NEW MEXICO

Inventor： UNIVERSITY OF NEW MEXICO ,  HJELLE, Brian ,  JENISON, Steve

IPC: G01N33/53

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K2319/00 ,  C12N2760/12122

Abstract: The invention provides HARDS virus rDNA for expression in molecular clones. The expressed products are useful in immunodiagnostics, prophylactics, and therapeutics for the HARDS virus and related hantaviruses. Of particular interest are a type-specific epitope of the HARDS virus G1 protein, and dominant epitopes of the HARDS virus N protein cross-reactive with antibodies to the HARDS virus and the related hantavirus PHV, both expressed by cDNA clones according to the invention.

Abstract translation: 本发明提供用于在分子克隆中表达的HARDS病毒rDNA。 表达的产品可用于HARDS病毒和相关的汉坦病毒的免疫诊断，预防和治疗。 特别感兴趣的是HARDS病毒G1蛋白的特异性表位，以及与针对本发明的cDNA克隆表达的HARDS病毒和相关汉坦病毒PHV的抗体交叉反应的HARDS病毒N蛋白质的优势表位。

公开(公告)号：EP0714513A1

公开(公告)日：1996-06-05

申请号：EP94927196.0

申请日：1994-08-25

Applicant: THE UNIVERSITY OF NEW MEXICO

Inventor： HJELLE, Brian ,  JENISON, Steve

IPC: G01N33 ,  A61K35 ,  A61K39 ,  A61P31 ,  C07K14 ,  C12N1 ,  C12N5 ,  C12N15 ,  C12P21

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K2319/00 ,  C12N2760/12122

Abstract: The invention provides HARDS virus rDNA for expression in molecular clones. The expressed products are useful in immunodiagnostics, prophylactics, and therapeutics for the HARDS virus and related hantaviruses. Of particular interest are a type-specific epitope of the HARDS virus G1 protein, and dominant epitopes of the HARDS virus N protein cross-reactive with antibodies to the HARDS virus and the related hantavirus PHV, both expressed by cDNA clones according to the invention.