公开(公告)号：WO1991015237A1

公开(公告)日：1991-10-17

申请号：PCT/CA1990000170

申请日：1990-05-25

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： UNIVERSITY OF SASKATCHEWAN ,  ACRES, Stephen, D. ,  BARIUK, Lorne, A. ,  POTTER, Andrew, A. ,  LAWMAN, Michael, J., P.

IPC: A61K39/102

CPC classification number: A61K39/102 ,  A61K39/00 ,  C07K14/285

Abstract: New proteins and subunit antigens from P. haemolytica for use in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The subunit antigens include immunogenic amino acid sequences of P. haemolytica fimbrial protein, P. haemolytica plasmin receptor protein, and P. haemolytica 50 K outer membrane protein and P. haemolytica leukotoxin. The antigens can be used in a vaccine composition, either alone or in combination. Also disclosed are methods of vaccination as well as methods of making the subunit antigens employed in the vaccines.

Abstract translation: 公开了用于刺激抗呼吸系统疾病例如肺炎的免疫的解脲索氏溶血杆菌的新蛋白质和亚基抗原，包括运​​送发热性肺炎。 亚单位抗原包括解脲葡萄球菌菌毛蛋白，溶血性解纤维细胞溶血素受体蛋白和溶血性解水多糖50K外膜蛋白和解放军溶血白细胞毒素的免疫原性氨基酸序列。 抗原可以单独或组合地用于疫苗组合物中。 还公开了接种疫苗的方法以及制备疫苗中使用的亚基抗原的方法。

公开(公告)号：EP0527724B1

公开(公告)日：1997-08-27

申请号：EP90906831.4

申请日：1990-05-25

Applicant: The University of Saskatchewan

Inventor： ACRES, Stephen, D. ,  BARIUK, Lorne, A. ,  POTTER, Andrew, A. ,  LAWMAN, Michael, J., P.

IPC: A61K39/102 ,  C12N15/31

CPC classification number: A61K39/102 ,  A61K39/00 ,  C07K14/285

Abstract: New proteins and subunit antigens from P. haemolytica for use in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The subunit antigens include immunogenic amino acid sequences of P. haemolytica fimbrial protein, P. haemolytica plasmin receptor protein, and P. haemolytica 50 K outer membrane protein and P. haemolytica leukotoxin. The antigens can be used in a vaccine composition, either alone or in combination. Also disclosed are methods of vaccination as well as methods of making the subunit antigens employed in the vaccines.

公开(公告)号：EP0527724A1

公开(公告)日：1993-02-24

申请号：EP90906831.0

申请日：1990-05-25

Applicant: The University of Saskatchewan

Inventor： ACRES, Stephen, D. ,  BARIUK, Lorne, A. ,  POTTER, Andrew, A. ,  LAWMAN, Michael, J., P.

IPC: A61K39 ,  A61P31 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N15 ,  C12P21 ,  C12R1

CPC classification number: A61K39/102 ,  A61K39/00 ,  C07K14/285

Abstract: L'invention a pour objet de nouvelles protéines et des antigènes de sous-groupes provenant de P. haemolytica, s'utilisant pour stimuler l'immunité contre des maladies respiratoires comme la pneumonie, y compris la pneumonie causée par le transport. Les antigènes de sous-groupes comprennent des séquences immunogènes amino-acides de la protéine periphérifine de P. haemolytica, de la proteine réceptrice de plasmine de P. haemolytica et de la protéine de membrane extérieure 50 K de P. haemolytica ainsi que de la leucotoxine de P. haemolytica. Les antigènes peuvent s'utiliser dans une composition de vaccin, soit seuls soit en combinaison. L'invention se rapporte également à des procédés de vaccination ainsi qu'à des procédés de production des antigènes de sous-groupes