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1.发明申请ASSEMBLED VIRAL PARTICLES AND THEIR USE IN A VACCINE TO ROTAVIRAL DISEASE 审中-公开组装的病毒颗粒及其在野生动物疫苗中的用途
公开(公告)号：WO1992007941A1
公开(公告)日：1992-05-14
申请号：PCT/CA1991000376
申请日：1991-10-24
Applicant: UNIVERSITY OF SASKATCHEWAN
Inventor： UNIVERSITY OF SASKATCHEWAN , REDMOND, Mark, J. , IJAZ, Mohammed, Khalid , PARKER, Michael, D.
IPC: C12N15/46
CPC classification number: C07K14/005 , A61K39/00 , C12N7/00 , C12N2720/12322 , C12N2720/12323 , Y10S530/826
Abstract: Assembled viral particles derived from rotavirus proteins are disclosed. The assembled particles include the inner capsid protein, VP6, in combination with either or both of the outer capsid proteins, VP4 and VP7. These assemblies can be used in vaccine compositions for the treatment and prevention of rotaviral disease.
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公开(公告)号：WO1993008290A1
公开(公告)日：1993-04-29
申请号：PCT/CA1992000449
申请日：1992-10-15
Applicant: UNIVERSITY OF SASKATCHEWAN
IPC: C12N15/62
CPC classification number: C07K14/005 , A61K39/00 , A61K39/0006 , A61K47/62 , A61K47/646 , A61K47/6829 , A61K47/6833 , A61K2039/6037 , C07K5/1019 , C07K5/1021 , C07K5/1024 , C07K7/23 , C07K14/285 , C07K14/655 , C07K16/26 , C07K2319/00 , C12N2720/12322
Abstract: New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to a selected antigen. The leukotoxin functions to increase the immunogenicity of the antigen fused thereto.
Abstract translation: 公开了新的免疫载体系统，编码相同的DNA以及这些系统的使用。 载体体系包括嵌合蛋白，其包含与选定抗原融合的白细胞毒素多肽。 白细胞毒素用于增加融合在其上的抗原的免疫原性。
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公开(公告)号：WO1992014152A1
公开(公告)日：1992-08-20
申请号：PCT/CA1992000032
申请日：1992-01-29
Applicant: UNIVERSITY OF SASKATCHEWAN
Inventor： UNIVERSITY OF SASKATCHEWAN , REDMOND, Mark, J. , CAMPOS, Manuel , MATTE, Gilbert, G. , HAINES, Deborah, M.
IPC: G01N33/569
CPC classification number: C07K14/005 , C12N2710/14143 , C12N2720/12322 , G01N33/5094 , G01N33/56966 , G01N33/56972 , G01N33/56983 , Y10S530/826
Abstract: Advantage is taken of the ability of rotaviral VP6 protein to home to macrophage and monocytes to provide label to these cells in either an in vitro or in vivo environment. Further, the ability to couple label to the VP6 protein and to couple VP6 to a targeting agent provides a mechanism for conducting label (or an effector moiety) to any desired target.
Abstract translation: 优点是轮状病毒VP6蛋白能够归巢于巨噬细胞和单核细胞，以在体外或体内环境中为这些细胞提供标记。 此外，将标记物与VP6蛋白偶联并将VP6偶联至靶向剂的能力提供了将标记（或效应子部分）导入任何所需靶标的机制。
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公开(公告)号：WO1996003998A1
公开(公告)日：1996-02-15
申请号：PCT/CA1995000442
申请日：1995-07-31
Applicant: UNIVERSITY OF SASKATCHEWAN
Inventor： UNIVERSITY OF SASKATCHEWAN , ESTRADA, Alberto , REDMOND, Mark, J. , LAARVELD, Bernard
IPC: A61K35/78
CPC classification number: A61K36/185 , A61K36/73 , A61K2300/00
Abstract: Novel Quinoa saponin pharmaceutical compositions are disclosed. The compositions are useful as immunological adjuvants, to stimulate nonspecific immunity, as well as to enhance an immunological response to a selected antigen. The Quinoa saponin compositions can also be used to enhance mucosal absorption of a drug administered therewith.
Abstract translation: 公开了新的藜麦皂苷药物组合物。 该组合物可用作免疫佐剂，以刺激非特异性免疫，以及增强对所选抗原的免疫应答。 喹啉皂苷组合物也可用于增强与其一起施用的药物的粘膜吸收。
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5.发明申请ACUTE PHASE PROTEINS FOR DETECTION AND PROGNOSIS OF INFECTION AND TISSUE DAMAGE 审中-公开用于检测和预防感染和组织损伤的急性期相关蛋白
公开(公告)号：WO1993009142A1
公开(公告)日：1993-05-13
申请号：PCT/CA1992000476
申请日：1992-11-06
Applicant: UNIVERSITY OF SASKATCHEWAN
Inventor： UNIVERSITY OF SASKATCHEWAN , CAMPOS, Manuel , REDMOND, Mark, J. , HARLAND, Richard
IPC: C07K15/00
CPC classification number: C07K14/47 , C07K14/811 , C07K16/18
Abstract: Acute phase proteins and antibodies thereto are disclosed, as well as methods of determining the presence and severity of infection and tissue damage by testing for these proteins. 17.5 kDa, 23 kDa and 37 kDa proteins have been identified in bovine subjects suffering from both infection and chemically induced tissue damage. The proteins are indicative of the severity and prognosis of disease. Antibodies thereto are useful in diagnostic assays.
Abstract translation: 公开了急性期蛋白质及其抗体，以及通过测试这些蛋白质来确定感染和组织损伤的存在和严重程度的方法。 已经在感染和化学诱导的组织损伤的牛受试者中鉴定了17.5kDa，23kDa和37kDa的蛋白质。 蛋白质指示疾病的严重性和预后。 其抗体可用于诊断测定。
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Patent Agency Ranking
公开(公告)号：WO1992013568A1
公开(公告)日：1992-08-20
申请号：PCT/CA1992000029
申请日：1992-01-29
Applicant: UNIVERSITY OF SASKATCHEWAN
Inventor： UNIVERSITY OF SASKATCHEWAN , REDMOND, Mark, J. , CAMPOS, Manuel
IPC: A61K47/42
CPC classification number: A61K9/5184 , A61K38/2013 , A61K38/217 , A61K47/6901 , C07K14/005 , C12N2710/14143 , C12N2720/12322
Abstract: Compositions and methods for preparing and delivering encapsulated biologically active agents to specific cell types are disclosed. Substances can be encapsulated in the VP6 inner capsid protein of rotavirus and delivered to selected cells, tissues and organs. Targeting agents can be linked to the surface of the VP6 sphere so that appropriate agents can be delivered to preselected cells and tissue types.
Abstract translation: 公开了用于制备和递送包封的生物活性剂到特定细胞类型的组合物和方法。 物质可以封装在轮状病毒的VP6内衣壳蛋白中，并被递送到选定的细胞，组织和器官。 靶向剂可以连接到VP6球体的表面，使得适当的药剂可以递送到预选的细胞和组织类型。
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7.发明授权ASSEMBLED VIRAL PARTICLES AND THEIR USE IN A VACCINE TO ROTAVIRAL DISEASE 失效同声问病毒粒子和它们在疫苗诱导ROTAVIRENKRANKHEIT
公开(公告)号：EP0652957B1
公开(公告)日：1997-05-07
申请号：EP91917981.2
申请日：1991-10-24
Applicant: The University of Saskatchewan
Inventor： REDMOND, Mark, J. , IJAZ, Mohammed, Khalid , PARKER, Michael, D.
CPC classification number: C07K14/005 , A61K39/00 , C12N7/00 , C12N2720/12322 , C12N2720/12323 , Y10S530/826
Abstract: Assembled viral particles derived from rotavirus proteins are disclosed. The assembled particles include the inner capsid protein, VP6, in combination with either or both of the outer capsid proteins, VP4 and VP7. These assemblies can be used in vaccine compositions for the treatment and prevention of rotaviral disease.
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公开(公告)号：EP0660723B1
公开(公告)日：1996-08-21
申请号：EP92902950.2
申请日：1992-01-29
Applicant: The University of Saskatchewan
Inventor： REDMOND, Mark, J. , CAMPOS, Manuel, Dr.
CPC classification number: A61K9/5184 , A61K38/2013 , A61K38/217 , A61K47/6901 , C07K14/005 , C12N2710/14143 , C12N2720/12322
Abstract: Compositions and methods for preparing and delivering encapsulated biologically active agents to specific cell types are disclosed. Substances can be encapsulated in the VP6 inner capsid protein of rotavirus and delivered to selected cells, tissues and organs. Targeting agents can be linked to the surface of the VP6 sphere so that appropriate agents can be delivered to preselected cells and tissue types.
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公开(公告)号：EP0660723A1
公开(公告)日：1995-07-05
申请号：EP92902950.0
申请日：1992-01-29
Applicant: The University of Saskatchewan
Inventor： REDMOND, Mark, J. , CAMPOS, Manuel, Dr.
CPC classification number: A61K9/5184 , A61K38/2013 , A61K38/217 , A61K47/6901 , C07K14/005 , C12N2710/14143 , C12N2720/12322
Abstract: Compositions and methods for preparing and delivering encapsulated biologically active agents to specific cell types are disclosed. Substances can be encapsulated in the VP6 inner capsid protein of rotavirus and delivered to selected cells, tissues and organs. Targeting agents can be linked to the surface of the VP6 sphere so that appropriate agents can be delivered to preselected cells and tissue types.
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10.发明公开ASSEMBLED VIRAL PARTICLES AND THEIR USE IN A VACCINE TO ROTAVIRAL DISEASE 失效同声问病毒粒子和它们在疫苗诱导ROTAVIRENKRANKHEIT。
公开(公告)号：EP0652957A1
公开(公告)日：1995-05-17
申请号：EP91917981.0
申请日：1991-10-24
Applicant: The University of Saskatchewan
Inventor： REDMOND, Mark, J. , IJAZ, Mohammed, Khalid , PARKER, Michael, D.
CPC classification number: C07K14/005 , A61K39/00 , C12N7/00 , C12N2720/12322 , C12N2720/12323 , Y10S530/826
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