公开(公告)号：US20230414566A1

公开(公告)日：2023-12-28

申请号：US18462920

申请日：2023-09-07

Applicant: University of Houston System

Inventor： Anton Dubrovskiy ,  Arcadius V. Krivoshein

IPC: A61K31/4015 ,  A61P25/08

CPC classification number: A61K31/4015 ,  A61K31/165 ,  A61P25/08

Abstract: Aryl-substituted acetamide and pyrrolidin-2-one (γ-butyrolactam) derivatives have useful activity in the inhibition, prevention, or treatment of seizures. The derivatives may be useful in the treatment of epilepsy, including medically refractory epilepsy, and nerve agent poisoning.

公开(公告)号：US11806333B2

公开(公告)日：2023-11-07

申请号：US16763738

申请日：2018-11-16

Applicant: University of Houston System

Inventor： Anton Dubrovskiy ,  Arcadius V. Krivoshein

IPC: A61K31/4015 ,  A61P25/08 ,  A61K31/165

CPC classification number: A61K31/4015 ,  A61P25/08 ,  A61K31/165

Abstract: Aryl-substituted acetamide and pyrrolidin-2-one (γ-butyrolactam) derivatives have useful activity in the inhibition, prevention, or treatment of seizures. The derivatives may be useful in the treatment of epilepsy, including medically refractory epilepsy, and nerve agent poisoning.