公开(公告)号：US10130713B2

公开(公告)日：2018-11-20

申请号：US14257594

申请日：2014-04-21

Applicant: University of Houston System

Inventor： Anders Berkenstam ,  Edward Kuczynski ,  Alf S. Andersson ,  Jan-Ake Gustafsson ,  Carly Sue Filgueira

IPC: A61K47/48 ,  C07C49/727 ,  A61K9/00 ,  C07C55/12 ,  C07C57/145 ,  C07C59/255 ,  C07J1/00 ,  A61K47/54 ,  A61K47/69

Abstract: A cocrystalline DHEA composition with at least one additional coformer is disclosed for therapeutic formulations. The cocrystalline DHEA/coformer formulation including at least one coformer chosen from the group consisting of glutaric acid, maleic acid, tartaric acid, fructose, and wherein the L-isomer of tartaric acid and the D-isomer of fructose are utilized. The cocrystalline DHEA/coformer formulations include certain excipients as a solubilizer or inhibitor.

公开(公告)号：US20140315833A1

公开(公告)日：2014-10-23

申请号：US14257594

申请日：2014-04-21

Applicant: University of Houston System

Inventor： Anders Berkenstam ,  Edward Kuczynski ,  Alf S. Andersson ,  Jan-Ake Gustafsson ,  Carly Sue Filgueira

IPC: A61K47/48 ,  C07C49/727

CPC classification number: A61K47/542 ,  A61K9/0053 ,  A61K47/549 ,  A61K47/6921 ,  C07B2200/13 ,  C07C55/12 ,  C07C57/145 ,  C07C59/255 ,  C07J1/0011

Abstract: A cocrystalline DHEA composition with at least one additional coformer is disclosed for therapeutic formulations. The cocrystalline DHEA/coformer formulation including at least one coformer chosen from the group consisting of glutaric acid, maleic acid, tartaric acid, fructose, and wherein the L-isomer of tartaric acid and the D-isomer of fructose are utilized. The cocrystalline DHEA/coformer formulations include certain excipients as a solubilizer or inhibitor.

Abstract translation: 公开了具有至少一种另外的共成形器的共结晶DHEA组合物用于治疗制剂。 包含选自戊二酸，马来酸，酒石酸，果糖和其中酒石酸的L-异构体和果糖的D-异构体的至少一种共成膜剂的共结晶DHEA /共形成形式配方。 共结晶DHEA /共形成剂制剂包括某些赋形剂作为增溶剂或抑制剂。