公开(公告)号：US11529309B2

公开(公告)日：2022-12-20

申请号：US16096603

申请日：2017-04-28

Applicant: University of Houston System

Inventor： Guoting Qin ,  Chengzhi Cai

IPC: A61K31/496 ,  A61K9/00 ,  A61L12/10 ,  C07C271/12 ,  C07C271/14 ,  C07D215/56

Abstract: Provided herein are fluorinated compounds having chemical structures: (I) where n is 0 or greater, or (II) where m and n are 0 or greater, or an amino acid, a soluble polymer, an oligo(ethylene glycol), a poly(ethylene glycol), or a carbohydrate each fluorinated with perfluorocarbons having the chemical structure (III) where n is 0 or greater. These fluorinated compounds are utilized in contact lenses to impart lipid-resistant, protein-resistant and biofouling-resistant properties, thus reducing discomfort and infection caused by contact lens wear without changing its transmission characteristics. Also provided is an ophthalmic drug delivery system comprising at least one of the compounds described above embedded in the contact lens and a kit to incorporate the ophthalmic into a contact lens. Methods for incorporating these compounds onto a contact lens without affecting transparency and for use in treating an ophthalmologic-associated condition are provided.

公开(公告)号：US12208159B2

公开(公告)日：2025-01-28

申请号：US17948376

申请日：2022-09-20

Applicant: University of Houston System

Inventor： Guoting Qin ,  Chengzhi Cai

IPC: A61K9/00 ,  A61K31/496 ,  A61L12/10 ,  C07C271/12 ,  C07C271/14 ,  C07D215/56

Abstract: Provided herein are fluorinated compounds having chemical structures: (I) where n is 0 or greater, or (II) where m and n are 0 or greater, or an amino acid, a soluble polymer, an oligo(ethylene glycol), a poly(ethylene glycol), or a carbohydrate each fluorinated with perfluorocarbons having the chemical structure (III) where n is 0 or greater. These fluorinated compounds are utilized in contact lenses to impart lipid-resistant, protein-resistant and biofouling-resistant properties, thus reducing discomfort and infection caused by contact lens wear without changing its transmission characteristics. Also provided is an ophthalmic drug delivery system comprising at least one of the compounds described above embedded in the contact lens and a kit to incorporate the ophthalmic into a contact lens. Methods for incorporating these compounds onto a contact lens without affecting transparency and for use in treating an ophthalmologic-associated condition are provided.

公开(公告)号：US20230012411A1

公开(公告)日：2023-01-12

申请号：US17948376

申请日：2022-09-20

Applicant: University of Houston System

Inventor： Guoting Qin ,  Chengzhi Cai

IPC: A61K9/00 ,  C07C271/12 ,  C07C271/14 ,  C07D215/56 ,  A61K31/496 ,  A61L12/10

Abstract: Provided herein are fluorinated compounds having chemical structures: (I) where n is 0 or greater, or (II) where m and n are 0 or greater, or an amino acid, a soluble polymer, an oligo(ethylene glycol), a poly(ethylene glycol), or a carbohydrate each fluorinated with perfluorocarbons having the chemical structure (III) where n is 0 or greater. These fluorinated compounds are utilized in contact lenses to impart lipid-resistant, protein-resistant and biofouling-resistant properties, thus reducing discomfort and infection caused by contact lens wear without changing its transmission characteristics. Also provided is an ophthalmic drug delivery system comprising at least one of the compounds described above embedded in the contact lens and a kit to incorporate the ophthalmic into a contact lens. Methods for incorporating these compounds onto a contact lens without affecting transparency and for use in treating an ophthalmologic-associated condition are provided.

公开(公告)号：US20190133932A1

公开(公告)日：2019-05-09

申请号：US16096603

申请日：2017-04-28

Applicant: GUOTING QIN ,  CHENGZHI CAI ,  UNIVERSITY OF HOUSTON SYSTEM

Inventor： Guoting Qin ,  Chengzhi Cai

IPC: A61K9/00 ,  A61K31/496 ,  A61L12/10

Abstract: Provided herein are fluorinated compounds having chemical structures: (I) where n is 0 or greater, or (II) where m and n are 0 or greater, or an amino acid, a soluble polymer, an oligo(ethylene glycol), a poly(ethylene glycol), or a carbohydrate each fluorinated with perfluorocarbons having the chemical structure (III) where n is 0 or greater. These fluorinated compounds are utilized in contact lenses to impart lipid-resistant, protein-resistant and biofouling-resistant properties, thus reducing discomfort and infection caused by contact lens wear without changing its transmission characteristics. Also provided is an ophthalmic drug delivery system comprising at least one of the compounds described above embedded in the contact lens and a kit to incorporate the ophthalmic into a contact lens. Methods for incorporating these compounds onto a contact lens without affecting transparency and for use in treating an ophthalmologic-associated condition are provided.