公开(公告)号：US09540418B2

公开(公告)日：2017-01-10

申请号：US14405762

申请日：2013-02-06

Applicant: University of Science and Technology of China

Inventor： Longping Wen ,  Yunjiao Zhang

IPC: C07K7/06 ,  C07K7/08 ,  C07K14/00

CPC classification number: C07K7/06 ,  C07K7/08 ,  C07K14/00

Abstract: The present invention provides a polypeptide able to specifically bind to rare-earth nanoparticles and the use thereof. The polypeptide comprises an amino acid sequence shown by SEQ ID NO: 1 or analogs thereof. The present invention further provides a method for screening a polypeptide having the capacity of specifically binding to rare-earth nanoparticles. The present invention further provides a method for regulating and controlling the in vivo and in vitro autophagy and toxicity of the rare-earth upconversionnanophosphor material, comprising mixing and incubating the polypeptide specifically binding to rare-earth nanoparticles with rare-earth upconversion nanophosphor material, such that the polypeptide specifically binds to the nanophosphor material, wherein the rare-earth upconversion nanophosphor material comprises the rare earth, and the polypeptide specifically binding to rare-earth nanoparticles comprises the amino acid sequence shown by CTARSPWIC (RE-0, SEQ ID NO: 1) or analogs thereof.

Abstract translation: 本发明提供能够特异性结合稀土纳米粒子的多肽及其用途。 多肽包含SEQ ID NO：1所示的氨基酸序列或其类似物。 本发明还提供了筛选具有特异性结合稀土纳米粒子的能力的多肽的方法。 本发明还提供了一种用于调节和控制稀土上转换纳米荧光体材料的体内和体外自噬和毒性的方法，包括将与稀土纳米颗粒特异性结合的多肽与稀土上转换纳米荧光体材料混合并孵育， 所述多肽特异性结合纳米荧光体材料，其中所述稀土上转换纳米荧光体材料包含稀土，并且与稀土纳米颗粒特异性结合的多肽包含CTARSPWIC（RE-0，SEQ ID NO： 1）或其类似物。

公开(公告)号：US20150361135A1

公开(公告)日：2015-12-17

申请号：US14405762

申请日：2013-02-06

Applicant: University of Science and Technology of China

Inventor： Longping Wen ,  Yunjiao Zhang

IPC: C07K7/06 ,  C07K14/00 ,  C07K7/08

CPC classification number: C07K7/06 ,  C07K7/08 ,  C07K14/00

Abstract: The present invention provides a polypeptide able to specifically bind to rare-earth nanoparticles and the use thereof. The polypeptide comprises an amino acid sequence shown by SEQ ID NO: 1 or analogues thereof. The present invention further provides a method for screening a polypeptide having the capacity of specifically binding to rare-earth nanoparticles. The present invention further provides a method for regulating and controlling the in vivo and in vitro autophagy and toxicity of the rare-earth upconversionnanophosphor material, comprising mixing and incubating the polypeptide specifically binding to rare-earth nanoparticles with rare-earth upconversion nanophosphor material, such that the polypeptide specifically binds to the nanophosphor material, wherein the rare-earth upconversion nanophosphor material comprises the rare earth, and the polypeptide specifically binding to rare-earth nanoparticles comprises the amino acid sequence shown by CTARSPWIC (RE-0, SEQ ID NO: 1) or analogues thereof.

Abstract translation: 本发明提供能够特异性结合稀土纳米粒子的多肽及其用途。 多肽包含SEQ ID NO：1所示的氨基酸序列或其类似物。 本发明还提供了筛选具有特异性结合稀土纳米粒子的能力的多肽的方法。 本发明还提供了一种用于调节和控制稀土上转换纳米荧光体材料的体内和体外自噬和毒性的方法，包括将与稀土纳米颗粒特异性结合的多肽与稀土上转换纳米荧光体材料混合并孵育， 所述多肽特异性结合纳米荧光体材料，其中所述稀土上转换纳米荧光体材料包含稀土，并且与稀土纳米颗粒特异性结合的多肽包含CTARSPWIC（RE-0，SEQ ID NO： 1）或其类似物。