公开(公告)号：US20250155406A1

公开(公告)日：2025-05-15

申请号：US18839329

申请日：2022-03-16

Applicant: University of Science and Technology of China

Inventor： Guangming Huang ,  Zhuanghao Hou

IPC: G01N27/68 ,  G01N33/92 ,  H01J49/00 ,  H01J49/02 ,  H01J49/04 ,  H01J49/16

Abstract: The present disclosure provides an integrated device for rapid pretreatment-ionization-detection comprising: (a) a fixing device for fixing a sample to be treated; b) a rapid pretreatment-ionization device comprising: a voltage output module for generating an AC voltage; a boost module for boosting and amplifying the voltage to achieve an adjustable pulse voltage of 1 mV-100 kV; a delay module for setting a delay time for the voltage output; and a trigger module for receiving a pulse voltage trigger; (c) a mass spectrometer; and (d) a timing control device for controlling the mass spectrometer and the rapid pretreatment-ionization device to collect a signal. According to the integrated device, mutual separation between analytes in a cell sample and separation between an analyte and a complex matrix can be achieved, and the separation time can reach a sub-millisecond level.