公开(公告)号：US10207030B2

公开(公告)日：2019-02-19

申请号：US15868625

申请日：2018-01-11

Applicant: University of Utah Research Foundation

Inventor： Amanda Elaine Brooks ,  David W. Grainger ,  Kristofer D. Sinclair ,  Benjamin Delbert Brooks

IPC: A61K35/32 ,  A61K9/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L27/30 ,  A61L27/36 ,  A61K31/7036 ,  A61L27/26 ,  B05D3/00 ,  B29C67/24 ,  B29K1/00 ,  B29L31/00

Abstract: In one aspect, the invention provides an implantable device comprising a uniform mixture of components including degradable polymer, inorganic bone particulate either natural or synthetic, a drug, and a soluble microporagen. In some embodiments, the uniform mixture further includes a soluble polymer macroporagen. In some embodiments, the uniform mixture is coated with an immobilized outer porous layer comprising or consisting of synthetic or natural inorganic bone granules. In further aspects, the invention provides an implantable device comprising a composite core of degradable polymer, bone, and a drug, and a coating comprising or consisting of microporous bone overlayer covering the degradable composite core.

公开(公告)号：US20180133374A1

公开(公告)日：2018-05-17

申请号：US15868625

申请日：2018-01-11

Applicant: University of Utah Research Foundation

Inventor： Amanda Elaine Brooks ,  David W. Grainger ,  Kristofer D. Sinclair ,  Benjamin Delbert Brooks

IPC: A61L27/58 ,  A61L27/26 ,  A61L27/30 ,  A61L27/36 ,  A61L27/54 ,  A61K31/7036 ,  B29C67/24 ,  B05D3/00 ,  B29L31/00 ,  B29K1/00

CPC classification number: A61L27/58 ,  A61K31/7036 ,  A61L27/26 ,  A61L27/306 ,  A61L27/3608 ,  A61L27/54 ,  A61L2300/406 ,  A61L2300/412 ,  A61L2300/62 ,  A61L2430/02 ,  A61L2430/24 ,  B05D3/002 ,  B05D2203/00 ,  B29C67/24 ,  B29K2001/08 ,  B29L2031/7532

Abstract: In one aspect, the invention provides an implantable device comprising a uniform mixture of components including degradable polymer, inorganic bone particulate either natural or synthetic, a drug, and a soluble microporagen. In some embodiments, the uniform mixture further includes a soluble polymer macroporagen. In some embodiments, the uniform mixture is coated with an immobilized outer porous layer comprising or consisting of synthetic or natural inorganic bone granules. In further aspects, the invention provides an implantable device comprising a composite core of degradable polymer, bone, and a drug, and a coating comprising or consisting of microporous bone overlayer covering the degradable composite core.

公开(公告)号：US20130209522A1

公开(公告)日：2013-08-15

申请号：US13759904

申请日：2013-02-05

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： Amanda Elaine Brooks ,  Benjamin Delbert Brooks ,  David W. Grainger

IPC: A61K47/46 ,  A61K31/431 ,  A61K38/14 ,  A61K31/496 ,  A61K31/7036 ,  A61K47/34

CPC classification number: A61K47/46 ,  A61K31/351 ,  A61K31/431 ,  A61K31/496 ,  A61K31/7036 ,  A61K35/32 ,  A61K38/14 ,  A61K47/34 ,  A61L27/3608 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/406 ,  A61L2400/08 ,  A61L2430/02 ,  C08L67/04 ,  C08L71/02

Abstract: In some embodiments, the invention provides an implant comprising a uniform mixture of degradable polymer, bone, and a drug. In some embodiments, the drug comprises an antibiotic. In some embodiments, diffusion of the drug from the implant at a therapeutic level is maintained for an amount of time longer than an amount of time that a pathogen is senescent. In some embodiments, diffusion of the drug from the implant at a therapeutic level is maintained for at least eight weeks, or at least ten weeks, or at least twelve weeks post-implantation. In some embodiments, the therapeutic level is maintained at an implantation site of the implant.In some embodiments, the implant is a solid, a paste, or a liquid. In some embodiments, the solid implant is carved or molded for insertion into a site of implantation in a vertebrate host prior to implantation. In some embodiments, the paste implant hardens following implantation. In some embodiments, the liquid implant is used to coat a prosthesis (e.g., a prosthesis made of a metal, a ceramic, a porcelain, or a combination of two or more of the foregoing).

Abstract translation: 在一些实施方案中，本发明提供了包含可降解聚合物，骨和药物的均匀混合物的植入物。 在一些实施方案中，药物包含抗生素。 在一些实施方案中，将药物从治疗水平的植入物扩散的时间长于病原体衰老的时间长度。 在一些实施方案中，药物从治疗水平的植入物的扩散在植入后保持至少八周，或至少十周，或至少十二周。 在一些实施例中，治疗水平保持在植入物的植入部位。 在一些实施例中，植入物是固体，糊剂或液体。 在一些实施例中，在植入之前，将固体植入物雕刻或模制成用于插入植入脊椎动物宿主的部位。 在一些实施例中，膏体植入物在植入后硬化。 在一些实施例中，液体植入物用于涂覆假体（例如，由金属，陶瓷，瓷器或前述的两个或多个的组合制成的假体）。