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公开(公告)号：US20160129157A1
公开(公告)日：2016-05-12
申请号：US14765662
申请日：2014-02-05
Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
Inventor： Amanda Brooks , David Grainger , Kristofer D. Sinclair , Benjamin Brooks
CPC classification number: A61L27/58 , A61K31/7036 , A61L27/26 , A61L27/306 , A61L27/3608 , A61L27/54 , A61L2300/406 , A61L2300/412 , A61L2300/62 , A61L2430/02 , A61L2430/24 , B05D3/002 , B05D2203/00 , B29C67/24 , B29K2001/08 , B29L2031/7532
Abstract: In one aspect, the invention provides an implantable device comprising a uniform mixture of components including degradable polymer, inorganic bone particulate either natural or synthetic, a drug, and a soluble microporagen. In some embodiments, the uniform mixture further includes a soluble polymer macroporagen. In some embodiments, the uniform mixture is coated with an immobilized outer porous layer comprising or consisting of synthetic or natural inorganic bone granules. In further aspects, the invention provides an implantable device comprising a composite core of degradable polymer, bone, and a drug, and a coating comprising or consisting of microporous bone overlayer covering the degradable composite core.
Abstract translation: 一方面，本发明提供了一种可植入装置，其包括均匀的组分混合物，包括可降解聚合物，天然或合成的无机骨颗粒，药物和可溶性微孔。 在一些实施方案中，均匀混合物还包含可溶性聚合物大分子。 在一些实施方案中，均匀混合物用包含合成或天然无机骨颗粒的固定的外多孔层涂覆。 在另外的方面，本发明提供了一种可植入装置，其包括可降解聚合物，骨骼和药物的复合芯，以及包含可微聚骨覆盖层或覆盖可降解复合芯的或由其组成的涂层。
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公开(公告)号：US10207030B2
公开(公告)日：2019-02-19
申请号：US15868625
申请日：2018-01-11
Applicant: University of Utah Research Foundation
Inventor： Amanda Elaine Brooks , David W. Grainger , Kristofer D. Sinclair , Benjamin Delbert Brooks
IPC: A61K35/32 , A61K9/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L27/30 , A61L27/36 , A61K31/7036 , A61L27/26 , B05D3/00 , B29C67/24 , B29K1/00 , B29L31/00
Abstract: In one aspect, the invention provides an implantable device comprising a uniform mixture of components including degradable polymer, inorganic bone particulate either natural or synthetic, a drug, and a soluble microporagen. In some embodiments, the uniform mixture further includes a soluble polymer macroporagen. In some embodiments, the uniform mixture is coated with an immobilized outer porous layer comprising or consisting of synthetic or natural inorganic bone granules. In further aspects, the invention provides an implantable device comprising a composite core of degradable polymer, bone, and a drug, and a coating comprising or consisting of microporous bone overlayer covering the degradable composite core.
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公开(公告)号：US20180133374A1
公开(公告)日：2018-05-17
申请号：US15868625
申请日：2018-01-11
Applicant: University of Utah Research Foundation
Inventor： Amanda Elaine Brooks , David W. Grainger , Kristofer D. Sinclair , Benjamin Delbert Brooks
IPC: A61L27/58 , A61L27/26 , A61L27/30 , A61L27/36 , A61L27/54 , A61K31/7036 , B29C67/24 , B05D3/00 , B29L31/00 , B29K1/00
CPC classification number: A61L27/58 , A61K31/7036 , A61L27/26 , A61L27/306 , A61L27/3608 , A61L27/54 , A61L2300/406 , A61L2300/412 , A61L2300/62 , A61L2430/02 , A61L2430/24 , B05D3/002 , B05D2203/00 , B29C67/24 , B29K2001/08 , B29L2031/7532
Abstract: In one aspect, the invention provides an implantable device comprising a uniform mixture of components including degradable polymer, inorganic bone particulate either natural or synthetic, a drug, and a soluble microporagen. In some embodiments, the uniform mixture further includes a soluble polymer macroporagen. In some embodiments, the uniform mixture is coated with an immobilized outer porous layer comprising or consisting of synthetic or natural inorganic bone granules. In further aspects, the invention provides an implantable device comprising a composite core of degradable polymer, bone, and a drug, and a coating comprising or consisting of microporous bone overlayer covering the degradable composite core.
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公开(公告)号：US09889235B2
公开(公告)日：2018-02-13
申请号：US14765662
申请日：2014-02-05
Applicant: University of Utah Research Foundation
Inventor： Amanda Brooks , David Grainger , Kristofer D. Sinclair , Benjamin Brooks
IPC: A61K9/00 , A61L27/54 , A61L27/58 , A61L27/30 , A61L27/36 , A61K31/7036 , A61L27/26 , B05D3/00 , B29C67/24 , B29K1/00 , B29L31/00
CPC classification number: A61L27/58 , A61K31/7036 , A61L27/26 , A61L27/306 , A61L27/3608 , A61L27/54 , A61L2300/406 , A61L2300/412 , A61L2300/62 , A61L2430/02 , A61L2430/24 , B05D3/002 , B05D2203/00 , B29C67/24 , B29K2001/08 , B29L2031/7532
Abstract: In one aspect, the invention provides an implantable device comprising a uniform mixture of components including degradable polymer, inorganic bone particulate either natural or synthetic, a drug, and a soluble microporagen. In some embodiments, the uniform mixture further includes a soluble polymer macroporagen. In some embodiments, the uniform mixture is coated with an immobilized outer porous layer comprising or consisting of synthetic or natural inorganic bone granules. In further aspects, the invention provides an implantable device comprising a composite core of degradable polymer, bone, and a drug, and a coating comprising or consisting of microporous bone overlayer covering the degradable composite core.
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