公开(公告)号：WO2015027005A1

公开(公告)日：2015-02-26

申请号：PCT/US2014051988

申请日：2014-08-21

Applicant: VERTEX PHARMA

Inventor： BRUMMEL CHRISTOPHER LEE ,  MALTAIS FRANCOIS ,  DEININGER DAVID D ,  LEDFORD BRIAN ,  DORSCH WARREN

IPC: C07D239/95 ,  C07B59/00 ,  C07D471/04

CPC classification number: C07D471/04 ,  C07B59/002 ,  C07D239/42 ,  C07D239/95 ,  C07F5/025

Abstract: The present invention relates to a deuterated pyrrolo[2,3-b]pyridinyl compound that is useful for inhibiting Janus kinases. The invention also relates to processes and intermediates useful for preparing such a compound.

Abstract translation: 本发明涉及用于抑制Janus激酶的氘代吡咯并[2,3-b]吡啶基化合物。 本发明还涉及可用于制备这种化合物的方法和中间体。

公开(公告)号：AU2014308831A1

公开(公告)日：2016-03-10

申请号：AU2014308831

申请日：2014-08-21

Applicant: VERTEX PHARMA

Inventor： BRUMMEL CHRISTOPHER LEE ,  MALTAIS FRANCOIS ,  DEININGER DAVID D ,  LEDFORD BRIAN ,  DORSCH WARREN

IPC: C07D239/95 ,  C07B59/00 ,  C07D471/04

Abstract: The present invention relates to a deuterated pyrrolo[2,3-b]pyridinyl compound that is useful for inhibiting Janus kinases. The invention also relates to processes and intermediates useful for preparing such a compound.

公开(公告)号：CA2921198A1

公开(公告)日：2015-02-26

申请号：CA2921198

申请日：2014-08-21

Applicant: VERTEX PHARMA

Inventor： BRUMMEL CHRISTOPHER LEE ,  MALTAIS FRANCOIS ,  DEININGER DAVID D ,  LEDFORD BRIAN ,  DORSCH WARREN

IPC: C07D239/95 ,  C07B59/00 ,  C07D471/04

Abstract: The present invention relates to a deuterated pyrrolo[2,3-b]pyridinyl compound that is useful for inhibiting Janus kinases. The invention also relates to processes and intermediates useful for preparing such a compound.

公开(公告)号：MX2016002176A

公开(公告)日：2016-06-23

申请号：MX2016002176

申请日：2014-08-21

Applicant: VERTEX PHARMA

Inventor： LEDFORD BRIAN ,  MALTAIS FRANCOIS ,  BRUMMEL CHRISTOPHER LEE ,  DEININGER DAVID D ,  DORSCH WARREN

IPC: C07D239/95 ,  C07B59/00 ,  C07D471/04

Abstract: La presente invención se relaciona con un compuesto de pirrolo[2,3-b]piridinilo deuterado que es útil para inhibir las cinasas Janus. La invención también se relaciona con procesos e intermediarios útiles para preparar tal compuesto.