公开(公告)号：WO2007095223A2

公开(公告)日：2007-08-23

申请号：PCT/US2007003767

申请日：2007-02-12

Applicant: VERTEX PHARMA ,  JIMENEZ JUAN-MIGUEL ,  COLLIER PHILIP

Inventor： JIMENEZ JUAN-MIGUEL ,  COLLIER PHILIP

IPC: C07D471/04 ,  A61K31/437 ,  A61P25/28 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。

公开(公告)号：WO2007117692A3

公开(公告)日：2008-01-10

申请号：PCT/US2007008819

申请日：2007-04-11

Applicant: VERTEX PHARMA ,  JIMENEZ JUAN-MIGUEL ,  KNEGTEL RONALD ,  ROBINSON DANIEL ,  COLLIER PHILIP

Inventor： JIMENEZ JUAN-MIGUEL ,  KNEGTEL RONALD ,  ROBINSON DANIEL ,  COLLIER PHILIP

IPC: C07D231/14 ,  A61K31/426 ,  A61P35/00 ,  C07D233/90 ,  C07D277/56

CPC classification number: C07D277/593 ,  C07D231/14 ,  C07D233/64 ,  C07D233/90 ,  C07D277/56

Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.

Abstract translation: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。

公开(公告)号：DK4043460T3

公开(公告)日：2024-08-26

申请号：DK22161962

申请日：2019-04-23

Applicant: MERCK PATENT GMBH ,  VERTEX PHARMA

Inventor： KULKARNI SHASHANK ,  YU HENRY ,  CLARK MICHAEL ,  BEMIS GUY ,  BOYD MICHAEL ,  CHANDUPATLA KISHAN ,  COLLIER PHILIP ,  DENG HONGBO ,  DONG HUIJUN ,  DORSCH WARREN ,  HOOVER RUSSELL R ,  JOHNSON MAC ARTHUR JR ,  PENNEY MARINA ,  RONKIN STEVEN ,  TAKEMOTO DARIN ,  TANG QING ,  WAAL NATHAN D ,  WANG TIANSHENG ,  LAUFFER DAVID J ,  LI PAN

IPC: C07D413/14 ,  A61K31/553 ,  A61P35/00 ,  C07D403/04 ,  C07D409/14 ,  C07D413/04

公开(公告)号：PL3784666T3

公开(公告)日：2022-07-18

申请号：PL19726792

申请日：2019-04-23

Applicant: MERCK PATENT GMBH ,  VERTEX PHARMA

Inventor： YU HENRY ,  CLARK MICHAEL ,  BEMIS GUY ,  BOYD MICHAEL ,  CHANDUPATLA KISHAN ,  COLLIER PHILIP ,  DENG HONGBO ,  DONG HUIJUN ,  DORSCH WARREN ,  HOOVER RUSSELL R ,  JOHNSON MAC ARTHUR JR ,  KULKARNI SHASHANK ,  PENNEY MARINA ,  RONKIN STEVEN ,  TAKEMOTO DARIN ,  TANG QING ,  WAAL NATHAN D ,  WANG TIANSHENG ,  LAUFFER DAVID J ,  LI PAN

公开(公告)号：AU2019261308A1

公开(公告)日：2020-10-22

申请号：AU2019261308

申请日：2019-04-23

Applicant: MERCK PATENT GMBH ,  VERTEX PHARMA

Inventor： YU HENRY ,  CLARK MICHAEL ,  BEMIS GUY ,  BOYD MICHAEL ,  CHANDUPATLA KISHAN ,  COLLIER PHILIP ,  DENG HONGBO ,  DONG HUIJUN ,  DORSCH WARREN ,  HOOVER RUSSELL R ,  JOHNSON JR MAC ARTHUR ,  KUKAMI SHASHANK ,  PENNEY MARINA ,  RONKIN STEVEN ,  TAKEMOTO DARIN ,  TANG QING ,  WAAL NATHAN D ,  WANG TIANSHENG ,  LAUFFER DAVID J ,  LI PAN

IPC: C07D413/14 ,  A61K31/553 ,  A61P35/00 ,  C07D403/04 ,  C07D409/14 ,  C07D413/04

Abstract: The present invention provides compounds of Formula (I'), or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g. cancer).

公开(公告)号：ES2400104T3

公开(公告)日：2013-04-05

申请号：ES08796922

申请日：2008-07-31

Applicant: VERTEX PHARMA

Inventor： JIMENEZ JUAN-MIGUEL ,  COLLIER PHILIP ,  MILLER ANDREW ,  GREEN JEREMY ,  GAO HUAI ,  HAMON SYLVAIN ,  DROS ALBERT

IPC: C07D471/04

Abstract: Un proceso para preparación de un compuesto de fórmula 5: **Fórmula** que comprende el paso de someter selectivamente a des-cloración un compuesto de fórmula 1: 5 **Fórmula** en condiciones de des-cloración adecuada para formar un compuesto de fórmula 2: **Fórmula**

公开(公告)号：NZ577768A

公开(公告)日：2012-01-12

申请号：NZ57776807

申请日：2007-12-19

Applicant: VERTEX PHARMA

Inventor： JIMENEZ JUAN-MIGUEL ,  COLLIER PHILIP ,  MILLER ANDREW

IPC: C07D403/14 ,  A61K31/506 ,  C07D471/04

Abstract: Disclosed are compounds of formula (I), wherein the substituents are as defined in the specification. The compounds are protein kinase inhibitors particularly useful as GSK-3 inhibitors. The compounds are used in the manufacture of a medicament for treating or lessening the severity of a disease or condition selected from diabetes, Alzheimer's disease, Huntington's disease, Parkinson's disease, AIDS-associated dementia, bipolar disorder, amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), multiple sclerosis (MS), schizophrenia, leukocytopenia, cardiomyocyte hypertrophy, stroke, and rheumatoid arthritis.

公开(公告)号：MX2010004819A

公开(公告)日：2010-07-05

申请号：MX2010004819

申请日：2008-10-31

Applicant: VERTEX PHARMA

Inventor： MORTIMORE MICHAEL ,  MILLER ANDREW ,  BRENCHLEY GUY ,  TWIN HEATHER ,  COLLIER PHILIP ,  JIMENEZ JUAN-MIGUEL ,  BOYALL DEAN ,  SETTIMO LUCA ,  YOUNG STEPHEN ,  DAVIS CHRISTOPHER ,  MAK CHAU ,  KEILY SHAZIA

IPC: C07D471/04 ,  A61K31/437 ,  A61P3/10 ,  A61P11/06 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00

Abstract: La presente invención se relaciona con compuestos de la fórmula (I) y (IA) útiles como inhibidores de la proteína cinasa (1ª). La invención también proporciona composiciones farmacéuticamente aceptables que comprenden tales compuestos y métodos para usar las composiciones en el tratamiento de diferentes enfermedades, afecciones o trastornos. La invención también proporciona procesos para preparar compuestos de las invenciones. (a): en particular la proteína cinasa Ctheta, en donde A y A' son independientemente -N- o C(R+)-. El anillo B es de cinco o seis miembros saturado carbocíclico o heterocíclico, R1, R2, r3, R4, R5, R6, R7, x y y son como se describen en la presente. (ver fórmula anexa).

公开(公告)号：CA2704266A1

公开(公告)日：2009-06-11

申请号：CA2704266

申请日：2008-10-31

Applicant: VERTEX PHARMA

Inventor： JIMENEZ JUAN-MIGUEL ,  MORTIMORE MICHAEL ,  COLLIER PHILIP ,  MILLER ANDREW ,  YOUNG STEPHEN ,  MAK CHAU ,  DAVIS CHRISTOPHER ,  TWIN HEATHER ,  BRENCHLEY GUY ,  BOYALL DEAN ,  KEILY SHAZIA ,  SETTIMO LUCA

IPC: C07D471/04 ,  A61K31/437 ,  A61P3/10 ,  A61P11/06 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00

Abstract: The present invention relates to compounds of formula (I) and (IA) useful as inhibitors of protein kinase (1a). The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions. (a) : in particular protein kinase C theta, wherein A and A' are independently -N- or -C(R+) -. Ring B is five- or six-membered saturated carbocyclic or heterocyclic R1, R2, R3, R4, R5, R6, R7, x and y are as described herein.

公开(公告)号：AU2008331733A1

公开(公告)日：2009-06-11

申请号：AU2008331733

申请日：2008-10-31

Applicant: VERTEX PHARMA

Inventor： DAVIS CHRISTOPHER ,  BRENCHLEY GUY ,  BOYALL DEAN ,  MAK CHAU ,  MILLER ANDREW ,  JIMENEZ JUAN-MIGUEL ,  SETTIMO LUCA ,  COLLIER PHILIP ,  KEILY SHAZIA ,  TWIN HEATHER ,  MORTIMORE MICHAEL ,  YOUNG STEPHEN

IPC: C07D471/04 ,  A61K31/437 ,  A61P3/10 ,  A61P11/06 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00