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公开(公告)号：WO2008094992A3
公开(公告)日：2008-12-04
申请号：PCT/US2008052443
申请日：2008-01-30
Applicant: VERTEX PHARMA , JIMENEZ JUAN-MIGUEL , BEMIS GUY , MALTAIS FRANCOIS , WANG TIANSHENG , KNEGTEL RONALD , DAVIS CHRIS , FRAYSSE DAMIEN , BOYALL DEAN , SETTIMO LUCA , YOUNG STEPHEN , MORTIMORE MICHAEL
Inventor： JIMENEZ JUAN-MIGUEL , BEMIS GUY , MALTAIS FRANCOIS , WANG TIANSHENG , KNEGTEL RONALD , DAVIS CHRIS , FRAYSSE DAMIEN , BOYALL DEAN , SETTIMO LUCA , YOUNG STEPHEN , MORTIMORE MICHAEL
IPC: C07D213/73 , A61K31/444 , A61K31/529 , A61P25/00 , A61P35/00 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
CPC classification number: C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
Abstract: The present invention relates to compounds represented by the following structural formula: (I) useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of µsing the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
Abstract translation: 本发明涉及由以下结构式表示的化合物：（I）可用作蛋白激酶的抑制剂。 本发明还提供包含所述化合物的药学上可接受的组合物和使组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：HK1215256A1
公开(公告)日：2016-08-19
申请号：HK16103327
申请日：2016-03-22
Applicant: VERTEX PHARMA
Inventor： BOYALL DEAN , DAVIS CHRISTOPHER , DODD JAMES , EVERITT SIMON , MILLER ANDREW , WEBER PETER , WESTCOTT JAMES , YOUNG STEPHEN , SETTIMO LUCA
IPC: C07D20060101 , A61K20060101 , A61P20060101
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公开(公告)号：AU2013348167A1
公开(公告)日：2015-05-28
申请号：AU2013348167
申请日：2013-11-19
Applicant: VERTEX PHARMA
Inventor： BOYALL DEAN , DAVIS CHRISTOPHER , DODD JAMES , EVERITT SIMON , MILLER ANDREW , WEBER PETER , WESTCOTT JAMES , YOUNG STEPHEN , SETTIMO LUCA
IPC: C07D403/12 , A61K31/4192 , A61P35/00 , C07D249/10 , C07D401/12 , C07D413/12
Abstract: The present invention relates to compounds useful as inhibitors of indoleamine 2,3-dioxygenase (IDO). The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications.. The compounds of this invention have formula I-A; wherein the variables are as defined herein.
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公开(公告)号：AU2011209649A1
公开(公告)日：2012-08-09
申请号：AU2011209649
申请日：2011-01-26
Applicant: VERTEX PHARMA
Inventor： JIMENEZ JUAN-MIGUEL , SETTIMO LUCA , FRAYSSE DAMIEN , BRENCHLEY GUY , DAVIS JOHN CHRISTOPHER , MILLER ANDREW W
IPC: C07D487/04 , A61K31/4985 , A61P29/00 , A61P37/00
Abstract: The present invention relates to pyrazolopyrazine compounds useful as inhibitors of protein kinase specially PKC theta. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：NZ585063A
公开(公告)日：2012-05-25
申请号：NZ58506308
申请日：2008-10-31
Applicant: VERTEX PHARMA
Inventor： JIMENEZ JUAN-MIGUEL , MORTIMORE MICHAEL , COLLIER PHILIP , MILLER ANDREW , YOUNG STEPHEN , MAK CHAU , DAVIS CHRISTOPHER , TWIN HEATHER , BRENCHLEY GUY , BOYALL DEAN , KEILY SHAZIA , SETTIMO LUCA
IPC: A61P35/00 , A61K31/437 , A61P3/10 , A61P11/06 , A61P17/06 , A61P19/02 , A61P29/00 , C07D471/04
Abstract: Disclosed are kinase inhibiting compounds of formula I or IA, or a pharmaceutically acceptable salt thereof, wherein the substituents are as described within the specification. An example of a compound of formula I or IA includes 2-(6-(1H-pyrazolo[3,4-b]pyridine-4-yl)pyridine-2-yl)-2-methylpropanenitrile. Further disclosed are processes for preparing a compound of formula I or IA, and a composition comprising a compound of formula I or IA and a pharmaceutically acceptable carrier, adjuvant, or vehicle. Also disclosed is the use of a compound of formula I or IA in the production of a medicament for treating or preventing a protein kinase-mediated condition, such as asthma, psoriasis, arthritis, rheumatoid arthritis, joint inflammation, multiple sclerosis, diabetes, inflammatory bowel disease, transplant rejection, T-cell leukaemias, lymphomas, and lupus.
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Patent Agency Ranking
公开(公告)号：MX2011000834A
公开(公告)日：2011-04-05
申请号：MX2011000834
申请日：2009-07-22
Applicant: VERTEX PHARMA
Inventor： KNEGTEL RONALD , BRENCHLEY GUY , JIMENEZ JUAN-MIGUEL , FRAYSSE DAMIEN , BOYALL DEAN , SETTIMO LUCA
IPC: C07D471/04 , A61K31/437 , A61P35/02 , A61P37/00
Abstract: La presente invención se relaciona con compuestos de las siguientes fórmulas: Fórmula (I) y (II) que son útiles como inhibidores de la proteína cinasa. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden tales compuestos y métodos para usar las composiciones en el tratamiento de diferentes enfermedades, afecciones o trastornos. La invención también proporciona procesos para preparar los compuestos de la invención.
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公开(公告)号：AU2009274023A1
公开(公告)日：2010-01-28
申请号：AU2009274023
申请日：2009-07-22
Applicant: VERTEX PHARMA
Inventor： JIMENEZ JUAN-MIGUEL , SETTIMO LUCA , FRAYSSE DAMIEN , BRENCHLEY GUY , BOYALL DEAN
IPC: C07D471/04 , A61K31/437 , A61P35/02 , A61P37/00
Abstract: The present invention relates to compounds of tricyclic pyrazolopyridine useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：AU2008210455A1
公开(公告)日：2008-08-07
申请号：AU2008210455
申请日：2008-01-30
Applicant: VERTEX PHARMA
Inventor： JIMENEZ JUAN-MIGUEL , KNEGTEL RONALD , DAVIS CHRIS , MORTIMORE MICHAEL , BEMIS GUY , MALTAIS FRANCOIS , SETTIMO LUCA , FRAYSSE DAMIEN , YOUNG STEPHEN , BOYALL DEAN , WANG TIANSHENG
IPC: C07D213/73 , A61K31/444 , A61K31/529 , A61P25/00 , A61P35/00 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：MX2012008641A
公开(公告)日：2012-11-23
申请号：MX2012008641
申请日：2011-01-26
Applicant: VERTEX PHARMA
Inventor： BRENCHLEY GUY , JIMENEZ JUAN-MIGUEL , FRAYSSE DAMIEN , SETTIMO LUCA , MILLER ANDREW W , DAVIS CHRISTOPHER JOHN
IPC: C07D487/04 , A61K31/4985 , A61P29/00 , A61P37/00
Abstract: La presente invención se refiere a compuestos de pirazolopirazina útiles como inhibidores de la proteína cinasa, en especial de PKCtheta. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden los compuestos y métodos para usar las composiciones en el tratamiento de diversas enfermedades, afecciones o trastornos. La invención también proporciona procesos para preparar compuestos de las invenciones.
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公开(公告)号：AU2011209651A1
公开(公告)日：2012-08-09
申请号：AU2011209651
申请日：2011-01-26
Applicant: VERTEX PHARMA
Inventor： JIMENEZ JUAN-MIGUEL , SETTIMO LUCA , FRAYSSE DAMIEN , BRENCHLEY GUY , DAVIS JOHN CHRISTOPHER , MILLER ANDREW W
IPC: C07D487/04 , A61K31/519 , A61P31/00
Abstract: The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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