公开(公告)号：HK1104292A1

公开(公告)日：2008-01-11

申请号：HK07109565

申请日：2007-09-04

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH S S ,  GROOTENHUIS P D J ,  MILLER M T ,  HAMILTON M

IPC: C07D20060101 ,  C07D231/40 ,  C07D233/88 ,  C07D263/48 ,  C07D271/10 ,  C07D271/113 ,  C07D277/46 ,  C07D277/54 ,  C07D277/82 ,  C07D285/12 ,  C07D285/135 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D493/10

公开(公告)号：HK1105970A1

公开(公告)日：2008-02-29

申请号：HK07111298

申请日：2007-10-18

Applicant: VERTEX PHARMA

Inventor： RUAH S S HADIDA ,  HAZLEWOOD A R ,  GROOTENHUIS P D J ,  GOOR F F VAN ,  SINGH A K ,  ZHOU JINGLAN ,  MCCARTNEY J

IPC: A61K20060101 ,  A61P20060101 ,  C07C20060101 ,  C07D20060101

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, composition thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.