公开(公告)号：HK1105970A1

公开(公告)日：2008-02-29

申请号：HK07111298

申请日：2007-10-18

Applicant: VERTEX PHARMA

Inventor： RUAH S S HADIDA ,  HAZLEWOOD A R ,  GROOTENHUIS P D J ,  GOOR F F VAN ,  SINGH A K ,  ZHOU JINGLAN ,  MCCARTNEY J

IPC: A61K20060101 ,  A61P20060101 ,  C07C20060101 ,  C07D20060101

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, composition thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：HK1152707A1

公开(公告)日：2012-03-09

申请号：HK11106875

申请日：2011-07-05

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARAH S ,  HAZLEWOOD ANNA R ,  GROOTENHUIS PETER D J ,  GOOR FREDERICK F VAN ,  SINGH ASHVANI K ,  ZHOU JINGLAN ,  MCCARTNEY J

IPC: C07D20060101 ,  A61K20060101 ,  A61P20060101 ,  C07C20060101 ,  G01N20060101

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, composition thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.