公开(公告)号：ZA200701629B

公开(公告)日：2008-09-25

申请号：ZA200701629

申请日：2004-10-21

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  DEININGER DAVID D ,  GRILLOT ANNE-LAURE ,  RONKIN STEVEN M ,  DEAN STAMOS ,  EMANUELE PEROLA ,  TIANSHENG WANG ,  ARNAUD LE TIRAN ,  JOSEPH DRUMM ,  LIAO YUSHENG

IPC: A61K20090101 ,  A61K31/4439 ,  A61K31/506 ,  A61P20090101 ,  A61P31/04 ,  C07D20090101 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

Abstract: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.

公开(公告)号：MY139124A

公开(公告)日：2009-08-28

申请号：MYPI20040267

申请日：2004-01-29

Applicant: VERTEX PHARMA

Inventor： CHARIFSON PAUL S ,  JOSEPH DRUMM ,  DEININGER DAVID D ,  ANNE-LAURE GRILLOT ,  YUSHENG LIAO ,  RONKIN STEVEN M ,  DEAN STAMOS ,  EMANUELE PEROLA ,  TIENSHENG WANG ,  ARNAUD LETIRAN

IPC: A61K31/44 ,  A61P31/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

Abstract: THE PRESENT INVENTION RELATES TO COMPOUNDS WHICH INHIBIT BACTERIAL GYRASE AND/OR TOPO IV AND PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS COMPRISING SAID COMPOUNDS. THESE COMPOUNDS, AND COMPOSITIONS THEREOF, ARE USEFUL IN TREATING BACTERIAL INFECTION. ACCORDINGLY, THE PRESENT INVENTION ALSO RELATES TO METHODS FOR TREATING BACTERIAL INFECTIONS IN MAMMALS.